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Biomedical subjects

C J Estler

Publications and source records attributed to C J Estler.

At least 55 records · Page 3Linked to original sources
PubMed1984

Blood and organ concentrations of tetracycline and doxycycline in female mice. Comparison to males.

In mice treated with 50 micrograms/g i.v. tetracycline (TC) or doxycycline (DC), respectively, drug concentrations have been measured in serum, whole blood, liver, kidneys, lungs, heart, skeletal muscle and bones. TC reached especially high concentrations in liver, kidneys and bones. DC was initially trapped by lung tissue and accumulated in liver and kidneys. Liver concentrations were higher for TC, kidney concentrations were higher for DC. In some tissues, e.g. liver and kidneys, TC and DC reached higher concentrations in females than in males.

Animals↗
PubMed1983

Investigation into the combined hepatotoxicity of rolitetracycline and ethinyloestradiol.

The effect of rolitetracycline (50 micrograms/g i.v.) alone or in combination with ethinylestradiol (0.1 and 1.0 micrograms/g s.c. once daily for 4 days) on liver function (BSP retention, serum GPT and SDH) and histomorphology was investigated in mice. Rolitetracycline alone increased liver weight, BSP-retention and serum GPT levels. Ethinylestradiol at the lower dose tended to enhance the BSP retention and the morphological changes of the liver produced by rolitetracycline but had no additional effect on the serum GPT and on liver weight. In contrast, hepatotoxic effects of the higher dose of ethinylestradiol were not further enhanced by rolitetracycline.

Animals↗
PubMed1982

Comparative evaluation of the effects of tetracycline, rolitetracycline and doxycycline on some blood parameters related to liver function.

A comparative study was made on the effects of tetracycline (TC), rolitetracycline (RTC), and doxycycline (DC) at doses of 10-100 micrograms/g i.v. on serum GOT, GPT, bilirubin and urea levels of male and female mice. All tetracyclines at doses of 50-100 micrograms/g caused an increase of serum GOT and GPT activities in females after 2-8 h. This effect was less pronounced in males. The serum urea levels were markedly raised by TC and DC (50-100 micrograms/g) and RTC (10-100 micrograms/g). This effect was produced only in females. It was long-lasting (up to 8 h) after TC and RTC and more transient after DC. Likewise the tetracyclines affected the serum bilirubin only in females but not in males. All tetracyclines (25-100 micrograms/g) increased the amount of unconjugated and total bilirubin. This effect was most pronounced after TC, which also reduced the level of conjugated bilirubin.

Alanine Transaminase↗
PubMed1981

Age dependency of rolitetracycline-induced hepatic steatosis.

A comparative study on the effect of rolitetracycline (50 micrograms/g i.v.) on the hepatic content of triglycerides and the release of esterified fatty acids from the liver into the blood was performed in young and adult NMRI mice of both sexes. Rolitetracycline caused an accumulation of triglycerides only in the livers of adult animals, the effect being much more pronounced in females than in males. In agreement with this a very strong inhibition of lipid release from the liver and a significant decrease of the esterified fatty acids of the serum was produced only in adult females. The results suggest that the livers of young animals of both sexes are relatively resistant to the steatotic effect of rolitetracycline.

Age Factors↗
PubMed1981

Comparison of distribution of doxycycline in mice after oral and intravenous application measured by a high-performance liquid chromatographic method.

Doxycycline levels in various organs of mice after i.v. and p.o. administration were measured by a high-performance liquid chromatography method. When given as a single dose (50 mg/kg) i.v. doxycycline accumulated in the lung. High concentrations were also measured in liver and kidneys. When 50 mg/kg doxycycline were administered by stomach tube to fed mice the antibiotic accumulated to a lesser degree in the lung. On the other hand, the antibiotic levels in the liver and the kidneys were higher as after i.v. injection. The absorption of doxycycline administered p.o. was about 92% and seemed not to be influenced by food in the stomach. The elimination half-life in mice was 170 min independent of the route of administration.

Administration, Oral↗
PubMed1981

Comparative evaluation of the effects of tetracycline and doxycycline on blood and liver lipids on male and female mice.

The effects of tetracycline and doxycycline (10-100 mg/g i.v.) on the triglyceride and cholesterol contents of liver and blood were studied comparatively in male and female mice. Only tetracycline increased the triglyceride content of the liver. The cholesterol content of the liver was raised by both tetracycline and doxycycline. Tetracycline and doxycycline increased the concentration of unesterified cholesterol and decreased esterified and total cholesterol in the serum. Most effects were more consistent or more pronounced in females than in males.

Animals↗