[Question of embryo toxicity from mercury in amalgam fillings].
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Dental Amalgam↗
Biomedical subjects
C J Estler
Publications and source records attributed to C J Estler.
The influence of tetracyclines on the aggregation of free and membrane-bound polysomes and on the RNA content of the liver of mice.
Tetracycline (100 micrograms/g) and, to a lesser extent, doxycycline (50 and 100 micrograms/g) inhibited the aggregation of free but not of membrane-bound polysomes in the livers of female NMRI mice. In addition tetracycline decreased the RNA content of the fraction of membrane-bound polysomes probably due to detachment from their membrane sites.
Animals↗
Concentration of ciprofloxacin in human serum, lung and pleural tissues and fluids during and after lung surgery.
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Aged↗
Plasma histamine levels in rats treated with trypanocidal diamidines.
The histamine levels in rat plasma treated with various new trypanocidal diamidines and diimidazolines were evaluated by HPLC and fluorometric detection. Equimolar doses (10 mumol/kg) of the new compounds raised the plasma histamine level to a much smaller degree than pentamidine or diminazene.
Amidines↗
[Geriatrics. Can we prolong life?].
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Aged↗
Alpha-adrenoceptor-blocking properties of some trypanocidal diamidines.
A series of trypanocidal diamidines and diimidazolines known to cause severe hypotension were tested for their alpha-adrenoceptor blocking properties in vitro. At the postsynaptic alpha 1-receptor of the guinea-pig aorta in vitro all compounds at doses of 0.5 to 50 mumol/l showed weak antagonistic effects against noradrenaline. Similar results were obtained at the presynaptic alpha 2-receptor of the rat vas deferens.
Adrenergic alpha-Antagonists↗
Serum level, half-life and apparent volume of distribution of doxycycline in geriatric patients.
The serum level, half-life and apparent volume of distribution of doxycycline were determined in geriatric patients. The serum level and apparent volume of distribution were higher than those reported for younger persons. The apparent volume of distribution was correlated with the serum iron and beta-globulin levels. The possible influence of binding of doxycycline to serum iron on its pharmacokinetics is discussed.
Age Factors↗
The effect of long-term ethanol treatment on a metal binding protein fraction in liver and kidneys of mice.
In mice 4-12 weeks ingestion of ethanol decreased the concentration of a metallothionein-like protein fraction in the liver but not in the kidneys. The zinc and copper concentration also tended to decrease in the liver and remained unaffected in the kidneys.
Alcoholism↗
[Local anesthetics. Properties, actions, pharmacokinetics].
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Anesthetics, Local↗
Combined effects of high doses of rolitetracycline and testosterone on the liver of mice.
The effects of rolitetracycline (50 micrograms/g i.v.) and testosterone proprionate (4 X 1 micrograms/g s.c.) singly and combined on liver weight, serum GPT, SDH and bromsulfophthalein clearance have been measured in young mice. Pretreatment with testosterone tended to enhance the effects of rolitetracycline on the serum enzymes but was otherwise not effective.
Alanine Transaminase↗
The effect of long-term ethanol treatment on the polysome profile of brain, liver, and kidneys of mice.
Female mice were fed ad libitum with a liquid diet containing 5% (w/w) ethanol. After 4-8 weeks the polysome profile of brain, liver and kidneys showed changes indicating an increased state of aggregation.
Animals↗
Quantitative assessment of the polysome profile of the livers of mice treated with tetracycline or doxycycline.
The influence of tetracycline and doxycycline (10-100 micrograms/g i.v.) on the aggregational state of ribosomes from mouse liver was tested. Both drugs caused a disaggregation of the ribosomes as evidenced by a rise of the monosomes + disomes/polysomes ratio. Tetracycline was much more potent than doxycycline, the minimum effective doses for tetracycline being 10 micrograms/g i.v. as compared to 100 micrograms/g for doxycycline. The results show that tetracycline but not doxycycline at therapeutic dose range may interfere with the protein synthesis of the liver.
Animals↗
Combined toxic effects of tetracycline and ethinyl estradiol on liver function of mice.
The combined effects of ethinyl estradiol (EE) (0.5 micrograms/g s.c. once daily for 4 days) and tetracycline (TC) or doxycycline (DC) (50 micrograms/g i.v.) on liver weight and water content, serum transaminases, alkaline phosphatase, urea, triglycerides, and cholesterol as parameters of various liver functions were investigated in mice. It became apparent that depending on the parameter tested synergistic and antagonistic effects may occur, e.g., synergistic effects were observed with the serum transaminases and liver cholesterol; antagonistic effects were seen with the serum urea and serum cholesterol.
Alanine Transaminase↗
Changes in serum transaminases, SDH and liver morphology after treatment with trypanocidal diamidines in mice.
The effects of 2 recently developed trypanocidal agents, Diamidinophenylindol (DAPI) and Diimidazolinophenylindol (DIPI) at doses of 10-30 micrograms/g intraperitoneally (i.p.) on serum GOT, GPT and sorbitol dehydrogenase (SDH) levels and on liver morphology have been investigated in mice. Pentamidine served as reference drug. Both agents caused dose-dependent increases in serum transaminases and SDH, and discrete morphological changes of the liver, e.g., fatty degenerations, azinoperipheral vacuolisation and alterations of the nuclei, at least at the higher dosage.
Alanine Transaminase↗
Effect of toxic doses of progesterone on hepatotoxic effects of tetracycline.
The combined effects of high doses of tetracycline and progesterone on parameters indicative for liver function (serum transaminases and urea, serum and liver triglycerides and cholesterol) have been studied in mice. Apart from disturbance of cholesterol metabolism tetracycline-induced liver dysfunction was not aggravated by progesterone.
Alanine Transaminase↗
[Mode of action of nootropic drugs].
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Animals↗
Comparative effects of tetracycline and doxycycline on liver function of young adult and old mice.
The effects of tetracycline and doxycycline (25 and 100 micrograms/g i.v.) on serum GOT, GPT, urea, bilirubin, cholesterol and triglycerides and on the hepatic cholesterol and triglyceride levels have been investigated comparatively in female mice of two age groups: young adult and old. Both tetracyclines caused increases in the serum transaminases and bilirubin and in the triglyceride and cholesterol contents of the liver that were less pronounced in old than in young adult mice. The reason for the age difference may be that doxycycline and tetracycline accumulated to a greater extent in the livers of the younger age group. Only the rise of the serum urea levels after tetracycline and doxycycline was greater in old mice than in the young adults.
Aging↗