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Biomedical subjects

C Ito

Publications and source records attributed to C Ito.

At least 199 records · Page 11Linked to original sources
PubMed1980

[Effects of 5-methyl-7-diethylamino-s-triazolo-(1, 5-a) pyrimidine (trapidil) on various experimental hyperlipemias (author's transl)].

Effects of 5-methyl-7-diethylamino-s-triazolo-1, 5-a) pyrimidine (trapidil, Rocornal), a therapeutic agent for ischemic heart disease, on various types of experimental hyperlipemias were studied. With administration of trapidil, elevation of serum high density lipoprotein cholesterol (HDL-C) levels and reduction in serum total cholesterol (TC), low density lipoprotein and very low density lipoprotein cholesterol (LDL-C) and the ratio of HDL-C to LDL-C (LDL-C/HDL-c) were observed in most disease models. Changes in HDL-C levels and LDL-C/HDL-C in the hyperlipemia induced by lipid-enriched diet in mice and in the hyperlipemia induced by high cholesterol diet in Japanese quails were of statistical significance. Also, amelioration of reduction in HDL-C induced by high fat emulsion plus 6-n-propyl-2-thiouracil in rats was observed to be significant. Moreover, trapidil significantly reduced TC, LDL-C levels and LDL-C/HDL-C in the hyperlipemia in hamsters. To investigate possible mechanisms of therapeutic effects of trapidil, blood enzyme activities in Japanese quails with hyperlipemia were assayed. Trapidil showed increases in plasma lipoprotein lipase and serum lecithin-cholesterol acyltransferase activities. These results suggest that trapidil may be an effective chemotherapeutic agent for treating ischemic heart disease.

Animals↗
PubMed1980

[Comparative study on the pharmacological activities of protizinic acid and various non-steroidal anti-inflammatory agents (author's transl)].

The potency of anti-inflammatory and ulcerogenic activities of a new anti-inflammatory agent, (10-methyl-7-methoxy-2-phenothiazinyl)-2-propionic acid (protizinic acid, PRT), was compared with those of various known non-steroidal anti-inflammatory agents in 5 experimental models. The ED30 of PRT in carrageenin edema with oral administration was 18.0 mg/kg and its potency was third following indomethacin (IM) and diclofenac sodium (DF), among the 15 agents tested. The ED50 of PRT in ultraviolet erythema with oral administration and the IC50 in protein denaturation were 1.07 mg/kg and 0.89 X 10(-5)M, respectively and the activities were the most potent among all agents. The IC50 of PRT in platelet aggregation induced by arachidonic acid was 5.55 X 10(-5)M and the rank of potency was sixth following to IM, DF, flufenamic acid, aluminium and ranked fifth following azapropazone, MF, alclofenac, metiazinic acid (MA), except for basic agents, mepirizole, benzydamine hydrochloride and tiaramide hydrochloride. Thus, PRT seemed to have a relatively weak ulcerogenic activity in contrast to potent anti-inflammatory activity. Also, PRT was superior to MA, an analogue of PRT, in potency of anti-inflammatory activity, in all experimental models.

Animals↗
PubMed1979

[Anti-inflammatory actions of proteases, bromelain, trypsin and their mixed preparation (author's transl)].

Anti-inflammatory actions of proteases, bromelain (BR), trypsin (TR) and their mixed preparation (KT) were studied mainly in rabbits using various experimental test methods. Inhibitory action of edema formation induced by carrageenin was observed to be dose dependent with oral administrations of KT. This inhibitory action of KT was more remarkable than actions of BR and TR, suggesting a possible synergism between the latter two. Such action was also observed with non-steroidal anti-rheumatic drugs, phenylbutazone (PB), indomethacin and acetylsalicylic acid. Oral administration of KT exerted definite inhibition or a tendency toward inhibition against paw edema induced by dextran, histamine or egg albumin or skin edema induced by anti-rabbit serum and thermal stimulation. Furthermore, inhibition of vascular permeability increase induced by histamine and bradykinin as well as a tendency toward inhibition against protein exudation in CMC-pouch method were observed. On the other hand, contrary to PB, potent inhibitory action was not manifested in the persistent proliferative inflammation models, the granuloma formation induced formalin soaked filter paper and cotton pellet and the mustard edema. Therefore, it can be deduced that the inhibitory action of KT against edema formation may be dependent mainly on the inhibitory action of vascular permeability increase and the anti-inflammatory action may be specific for acute exudative inflammation.

Animals↗