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Biomedical subjects

C Hirayama

Publications and source records attributed to C Hirayama.

At least 145 records · Page 8Linked to original sources
PubMed1980

Antibodies to denatured bovine collagens in sera of patients with liver disease.

Sera from 101 patients with liver disease were studied for the presence of antibodies to three types of denatured bovine collagens by passive haemagglutination assay. A high incidence and titres were found especially in chronic active hepatitis, liver cirrhosis and primary hepatoma. The incidence and titres of antibodies to Type I and Type III collagens were significantly higher than those of antibodies to Type II collagen. Analysis by gel filtration on Sephadex G-200 or absorption with anti-IgG and IgM antisera revealed that the antibodies belonged to both IgG and IgM classes. They correlated with serum gamma-globulin levels, but not with rheumatoid factor.

Adolescent↗
PubMed1979

Unconjugated bilirubin kinetics in Dubin-Johnson syndrome.

Plasma unconjugated bilirubin kinetics were studied by a two-compartment analysis in 10 patients with Dubin-Johnson syndrome (DJS) and 7 normal controls. The clearance of unconjugated bilirubin from plasma was significantly reduced in the patients with DJS as compared to the controls (p less than 0.01). Kinetic analysis of plasma disappearance data showed an increase in reflux and decrease in conjugation. These results indicate that defects in both conjugated and unconjugated bilirubin metabolism exist in DJS.

Adult↗
PubMed1979

Serum cholesterol and squalene in hepatocellular carcinoma.

In 15 patients with hepatocellular carcinoma, the serum squalene level is raised significantly in parallel with the serum cholesterol level, though significantly decreased in patients with cholestatic hepatobiliary disease. Serum levels of cholesterol and/or squalene, therefore, could be regarded as a laboratory index reflecting a peculiar sterol metabolism in hepatocellular carcinoma.

Adult↗
PubMed1979

[Radioimmunoassay of cholylglycine in serum (author's transl)].

Serum levels of cholylglycines (CG) were determined by radioimmunoassay and that of total bile acids (TBA) by enzymatic method. In normal subjects, serum levels of CG, TBA and CG/TBA ratio were 0.6 +/- 0.4 micronM, 7 +/- 2 micronM and 0.08 +/- 0.06, respectively. They were increased markedly in acute hepatitis and moderately in chronic hepatitis and cirrhosis. Thus, measurement of serum CG as compared with serum TBA appears to be a sensitive liver test.

Bile Acids and Salts↗
PubMed1979

Effect of chronic ethanol administration on serum high density lipoprotein cholesterol in rat.

In rats chronic ethanol administration was found in fasting state not to induce hypertriglyceridemia but moderate hypercholesterolemia through an increased level of high density lipoprotein cholesterol. In the liver, cholesterol contents slightly and triglyceride centents significantly increased. The result suggests that cholesterol accumulation in the liver leads to an increased level of high density lipoprotein cholesterol.

Animals↗
PubMed1979

Dye clearance studies in Rotor's syndrome.

Plasma clearances of sulfobromophthalein sodium (BSP), indocyanine green (ICG) and unconjugated bilirubin were studied in six patients with Rotor's syndrome. A marked retention of these three substances in the plasma was observed. At 60 minutes after injection, serum BSP consisted almost entirely of the unconjugated form. In three patients, BSP Tm and BSP S were significantly reduced. Clearance of unconjugated bilirubin was markedly impaired. This, together with the conjugated hyperbilirubinemia may be interpreted to reflect reduced storage. These results indicate that Rotor's syndrome is marked by reduced hepatic storage capacity and excretory function of BSP, ICG and bilirubin.

Adolescent↗
PubMed1978

Serum squalene levels in hepatobiliary diseases.

Serum squalene levels did not change in patients with acute hepatitis, chronic active hepatitis and liver cirrhosis, but were significantly reduced in patients with intra- and extrahepatic cholestasis. The ratio of cholesterol to squalene remained normal in patients with acute hepatitis as well as chronic active hepatitis, while being slightly decreased in patients with liver cirrhosis. On the other hand, in patients with cholestasis the ratio was markedly raised. From these observations we confirmed abnormal sterol metabolism in hepatobiliary diseases, and clinical usefulness of the ratio of cholesterol to squalene to distinguish hepatocellular injury and cholestasis.

Acute Disease↗
PubMed1978

Value of B-scan ultrasonography in the diagnosis of liver cancer. Accuracy compared to scintigraphy and angiography.

Seventy-one patients with liver cancer were examined by B-scan ultrasonography. The presence of liver cancer was assumed through the irregularity and increased intensity of echos. The accuracy of ultrasonography in the diagnosis of liver cancer was 72%, while the diagnostic accuracy of scintigraphy was 85% and angiography 93%. No obvious correlation could be demonstrated between the ultrasonographic patterns and serum alpha-fetoprotein (AFP) levels. Ultrasonography is a useful method of detecting liver cancer.

Adult↗
PubMed1977

Effect of corticosteroid treatment on bilirubin metabolism in chronic aggressive hepatitis.

The metabolism of unconjugated bilirubin from the plasma was studied in 17 patients with chronic hepatitis and 7 normal subjects following a single injection of bilirubin of 2 mg per kg body weight. From the plasma disappearance curves of unconjugated bilirubin, hepatic uptake, reflux from the liver to the plasma and hepatic conjugation were calculated by 2 compartmental analysis. The clearance remained within normal range in 5 patients with chronic persistent hepatitis but was significantly impaired in 12 patients with chronic aggressive hepatitis, in which corticosteroid treatment improved the clearance significantly (p less than 0.01). Since urinary excretion of d-glucaric acid remained unchanged by corticosteroid treatment, the improved clearance may be attributable to increased hepatic parenchymal function.

Adult↗
PubMed1976

Serum cholesterol and bile acid in primary hepatoma.

The close relationship between serum levels of cholesterol and bile acid has been confirmed in 46 patients with primary hepatoma. Serum levels of cholesterol and bile acid are roughly correlated with serum alpha-fetoprotein concentration. Because the relationship between serum cholesterol and bile acid did not exist in common hepatocellular diseases, the results suggest a peculiar sterol metabolism occurring in human hepatoma.

Adult↗
PubMed1975

Serum haptoglobin type and liver cirrhosis.

Haptoglobin phenotypes were studied by a polyacrylamide gel electrophoresis on 200 blood donors and 105 patients with liver cirrhosis, of which 79% belonged to non-alcoholic etiology. Though no difference of haptoglobin types could be found between blood donors with positive and negative hepatitis B antigen, the cirrhois patients had an excess haptoglobin gene 1. The patients with haptoglobin gene 1 were associated with severe liver dysfunction. Since the family pedigrees of the patients with type 1--1 excluded individuals with type 2--2, the phenotypes seemed to be stable in the cirrhotic process. The possibility that the haptoglobin 2 gene offered resistence to the non-alcoholic cirrhosis was discussed.

Adult↗
PubMed1975

Studies on the relationship of hepatic anion-binding proteins and sulfobromophthalein-glutathione conjugation in normal and phenobarbital-treated rats.

The enzyme activity which conjugates sulfobromophthalein with glutathione was separated from rat liver supernate by Sephadex G-75 gel filtration, and assayed by two different methods; paper electrophoresis and spectrophotometry. The enzyme activity was found mainly in the second protein fraction, and less than 5% of the activity in the first or third protein fractions. In vitro mixtures of sulfobromophthalein, [3-H]glutathione and rat liver supernate showed that the major part of [3-H]glutathione was detected in the first and second protein fractions, and the remainder in the third protein fraction. Phenobarbital treatment caused an increase of the enzyme activity, sulfobromophthalein and [3-H]glutathione, in the second protein fraction.

Animals↗