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Biomedical subjects

C Hirayama

Publications and source records attributed to C Hirayama.

At least 127 records · Page 7Linked to original sources
PubMed1982

Anti-albumin antibodies in sera of patients with liver disease.

We used passive haemagglutination assay to examine sera from 77 patients with various liver diseases for the presence of antibodies to human serum albumin (HSA), bovine serum albumin (BSA) ans ovalbumin (OA). The antibody titre to BSA was higher than that to OA or HSA. Of the examined diseases, in chronic active hepatitis and liver cirrhosis, the titre and incidence of anti-BSA antibody were highest. There was a positive correlation between anti-BSA antibody and serum gamma-globulin level. Sephadex G-200 column chromatography and immunoelectrophoresis revealed that the anti-BSA antibody belonged to the IgM class.

Adult↗
PubMed1982

Therapeutic effects of tiopronin on chronic hepatitis: a double-blind clinical study.

The efficacy of tiopronin (2-mercaptopropionyl glycine) 600 mg daily in the treatment of chronic active or chronic persistent hepatitis has been assessed in a double-blind controlled clinical trial of 12 weeks involving 165 Japanese patients with histologically proven disease. Treatment with the drug was associated with a significant improvement in abnormalities of serum transaminase and gamma glutamyl transpeptidase, with reversion towards baseline values on stopping the drug. Improvement was independent of the histological classification of the disease, or HBsAg status. The drug was well tolerated with few side-effects. The results of this short-term study indicate that tiopronin may be of value in the treatment of chronic hepatitis.

Acyltransferases↗
PubMed1982

Effects of phenobarbital on unconjugated bilirubin clearance, gamma-glutamyltranspeptidase and urinary d-glucaric acid in patients with Gilbert's syndrome.

Plasma unconjugated bilirubin kinetics, gamma-glutamyltranspeptidase (GGT) and urinary excretion of d-glucaric acid were determined in 7 patients with Gilbert's syndrome, before and after phenobarbital treatment. The clearance of unconjugated bilirubin from plasma was significantly improved after treatment (p less than 0.005). Kinetic analysis of plasma disappearance data was associated with an increase in uptake and conjugation, and a decrease in reflux. Phenobarbital treatment resulted in significant increases in serum GGT activity (p less than 0.05) and urinary d-glucaric acid excretion (p less than 0.005). These results suggest that measurement or urinary d-glucaric acid by short-term administration of phenobarbital may be a better clinical index for hepatic microsomal enzyme induction than serum GGT activity.

Adult↗
PubMed1982

Spontaneous rupture of the spleen secondary to metastatic hepatocellular carcinoma: a report of a case and review of the literature.

An extremely rare case of splenic rupture at the site of metastasis of hepatocellular carcinoma is reported. A 62-yr-old woman with hepatocellular carcinoma and its suspected metastasis to the spleen died of intraperitoneal hemorrhage. Autopsy disclosed a laceration of the spleen as the definitive cause of the hemorrhage. There were multiple nodules of metastatic hepatocellular carcinoma in the spleen, some of which were exposed at the lacerated portion of the splenic capsule. This may be the first report of a case of spontaneous rupture of the spleen secondary to metastatic hepatocellular carcinoma. Splenic rupture can be one of the causes of hemoperitoneum in patients with hepatocellular carcinoma.

Carcinoma, Hepatocellular↗
PubMed1982

[Liver cirrhosis].

Explore the source record for details and available documents.

Hemodynamics↗
PubMed1981

Abnormality of oral ursodeoxycholic acid tolerance test in the Dubin-Johnson syndrome.

Serial measurement of serum bile acid levels before and after oral administration of ursodeoxycholic acid (UDCA) was performed in 10 patients with Dubin-Johnson acid levels were significantly elevated in the patients compared with the controls (p less than 0.05). Oral UDCA tolerance studies revealed impaired bile acid clearance from serum in the patients and showed markedly increased serum bile acid levels 120 min after administration (p less than 0.01). These results indicate that some DJS patients have abnormal bile clearance which may be attributable to defects in hepatic uptake and biliary excretion of bile acids.

Adult↗
PubMed1981

Oral ursodeoxycholic acid tolerance test in patients with digestive disease.

Serial measurement of serum bile acid levels was carried out in patients with digestive diseases before and after oral loading with 500 mg of ursodeoxycholic acid. In control cases, serum bile acid reached the maximum level 30 min after loading. Elevation also, of cholic, chenodeoxycholic and deoxycholic acid levels was noted in addition to marked enhancement of the ursodeoxycholic acid level. In patients with chronic aggressive hepatitis and cirrhosis, the serum bile acid level was higher than the controls in fasting state, and increased more significantly after loading. On the other hand, in patients with small intestinal disorders, the serum bile acid level in fasting state tended to be lower than the controls, and became significantly lower after loading. Thus, oral ursodeoxycholic acid tolerance test is found to be useful as a diagnostic test for digestive diseases.

Adult↗
PubMed1981

A random controlled study of the prophylactic effect of lysozyme chloride on post-transfusion hepatitis.

In a study designed to determine the preventive effect of lysozyme on post-transfusion hepatitis, 260 patients with orthopedic diseases, who received blood by transfusion during a period of 5 years from June 1970 to May 1975, were divided at random into a group of 123 patients treated with lysozyme is doses of 60 to 170 mg/day for 4 to 24 weeks, and a control group of 137 patients. The incidence of post-transfusion hepatitis was 10 (8.1%) out of 123 patients for the treated group, and 28 (20.4%) out of 137 patients for the control group. Icteric hepatitis occurred in 1 (0.8%) patient in the treated group, while its incidence in the control group was 8 (5.8%) out of 137 patients.

Adult↗
PubMed1980

Hepatic collagenolytic cathepsin in patients with chronic liver disease.

Human hepatic collagenolytic cathepsin consisted of a major component having a molecular weight of 25 000 and a minor one of 35 000; the former is indistinguishable for cathepsin B in its enzymatic properties. Hepatic collagenolytic cathepsin increased in chronic active liver disease in proportion to hepatic hydroxyproline content. The ratio of collagenolytic cathepsin to hepatic hydroxyproline content remained within the normal range in chronic hepatitis, but decreased significantly in cirrhosis. These results suggest that collagenolytic cathepsin participates, at least partly, in the progress of hepatic fibrosis.

Cathepsin B↗
PubMed1980

Clinical evaluation of serum levels of tryptophan in hepatobiliary disease.

Fasting serum levels of total and free tryptophan, and free fatty acids and albumin, were measured and compared by blood biochemical analysis in patients with hepatobiliary disease and neuropsychiatric symptoms. The serum total tryptophan level tended to be elevated in patients with chronic active hepatitis, hepatic coma and obstructive jaundice, but not significantly. The serum free tryptophan level was significantly elevated in patients with chronic active hepatitis, liver cirrhosis, primary hepatocellular carcinoma and obstructive jaundice. The free tryptophan level was related to the decreased serum albumin level and elevated serum free fatty acid levels, which seems to indicate a connection with liver parenchymal function. The level, however, seemed not to correlate with neuropsychiatric symptoms.

Acute Disease↗
PubMed1980

Pneumatosis cystoides intestinalis: Report of 3 cases with special reference to its non-surgical treatment.

Three patients with pneumatosis cystoides intestinalis had been reported. All patients are females with lesions in the left and sigmoid colon, grouped as idiopathic etiology. Two patients are in middle age, workers in the manufacturing plant for electric apparatus. One patient received surgical resection of the affected segment. After oral antibiotics treatment, one patient was resected only the intensely affected segment, so that many cysts were still remained, but they disappeared after 3 weeks. One patient was treated with lactobacillus preparations and lactulose. Her subjective symptoms and fecal occult blood disappeared, and X-ray studies and endoscopic examination revealed an almost complete recovery.

Adult↗