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Biomedical subjects

C Harris

Publications and source records attributed to C Harris.

At least 235 records · Page 13Linked to original sources
PubMed1982

Ethosuximide kinetics: possible interaction with valproic acid.

Ethosuximide kinetics were determined in six normal healthy adults after a single dose (phase 1) and at steady-state (phase 2). After the completion of phase 2, valproic acid was added to the ethosuximide regimen (phase 3) to assess the possibility of drug interaction. Between phases 1 and 2 total clearance fell from 13.1 to 11.1 ml/hr/kg (P less than 0.05) and nonrenal clearance fell from 10.1 to 8.3 ml/hr/kg (P less than 0.05). When valproic acid was added (phase 3) there was no further change in total or nonrenal clearance (11.2 and 8.3 ml/hr/kg). To assess the possibility of nonlinear ethosuximide kinetics a review was conducted of patients who received ethosuximide as sole therapy for absence seizures. Of 106 patients, 10 met the required criterion that defined steady state. Data from seven of the 10 patients showed evidence of a nonlinear relationship when steady-state ethosuximide concentrations were plotted against dose.

Adult↗
PubMed1982

A conceptual model for determining the least restrictive treatment-training modality.

Much attention has been paid in recent years to the concept of the least restrictive treatment or training for developmentally disabled individuals. However, few well-defined procedures exist for determining the restrictiveness of modalities commonly used with these individuals. The authors identified ten frequently used modalities and six criteria for determining their relative restrictiveness. A total of 97 mental health professionals rated each modality according to the criteria, and a generalized rank order of the ten was obtained. Criteria were then established for applying the more restrictive modalities to individual residents' cases. The authors propose a four-part review process to ensure that the individual needs and rights of residents are respected.

Deinstitutionalization↗
PubMed1981

An open comparison of dosage frequencies of beclomethasone dipropionate in seasonal allergic rhinitis.

In an open group-comparative study, 123 adult patients with seasonal allergic rhinitis were allocated at random to one of three treatment groups; each of which received a daily dose of 400 micrograms beclomethasone dipropionate as (1) one puff in each nostril four times daily, (2) two puffs in each nostril twice daily and (3) four puffs in each nostril once per day. The result of treatment was assessed on daily symptom scores and the use of antihistamine tablets. There were no statistically significant differences between the three groups. The results indicate that it is unnecessary to give beclomethasone dipropionate nasal spray four times daily, and treatment in the morning and in the evening is recommended.

Adolescent↗
PubMed1981

Binding of fibronectin to Clq; inhibition of binding by aggregated IgG.

Fibronectin was shown to bind to C1q using alkaline phosphatase conjugated fibronectin and C1q coated polystyrene tubes. The binding of the alkaline phosphatase conjugated fibronectin to C1q was dose dependent and inhibited by fibronectin and by the sulfated polymers heparin and chondroitin sulfate. The fibronectin interaction was inhibited only slightly by gelatin indicating that the fibronectin-gelatin interaction was different from that with C1q. Heat aggregated IgG blocked the binding of fibronectin to C1q and fibronectin inhibited the binding of aggregated IgG to C1q. These results suggest that fibronectin may be a factor affecting the determination of immune complexes in serum specimens by C1q binding assays.

Alkaline Phosphatase↗
PubMed1981

Injuries to the upper extremity: patterns of occurrence.

Injuries to the upper extremity, as reported in home interviews, physician office records, and hospital records, are a problem of great magnitude. Upper extremity injuries not only are responsible for a great deal of disability and for a large number of visits for medical care, but also, because they often affect people of working age, have a great impact on society because of loss of productivity. However, regardless of the age at which they occur, these injuries can have an impact on the quality of life of the injured, both in the short term and in the long.

Adolescent↗