Search PubMed⌕ Search

Biomedical subjects

C Hansch

Publications and source records attributed to C Hansch.

213 records · Page 12Linked to original sources

The importance of hydrophobicity in the mutagenicity of methanesulfonic acid esters with Salmonella typhimurium TA100.

The analysis of the mutagenic activity of a series of 15 methanesulfonate esters with Salmonella typhimurium TA100 shows that it can be correlated with the following equation: log TA100 = 1.10 log P + 0.73 log MMI -2.53, where MMI is the relative rate of reaction of the esters with N-methyl-2-mercaptoimidazole and P is the octanol/water partition coefficient. The results are compared with a number of other structure-activity studies on mutagenesis by a variety of types of chemicals.

Animals↗