Comparison of parameters currently used in the study of structure-activity relationships.
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Anesthesia↗
Biomedical subjects
C Hansch
Publications and source records attributed to C Hansch.
Passive permeation of organic compounds through biological tissue: a non-steady-state theory.
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Animals↗
Correlation of ratios of drug metabolism by microsomal subfractions with partition coefficients.
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Animals↗
Structure--activity correlations in the metabolism of drugs.
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Alcohols↗
An analysis of the structure-activity relationship in the adrenergic blocking activity of the beta-haloalkylamines.
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Animals↗
The linear free-energy relationship between partition coefficients and the binding and conformational perturbation of macromolecules by small organic compounds.
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Acids↗
The parabolic dependence of drug action upon lipophilic character as revealed by a study of hypnotics.
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Alcohols↗
Structure-activity correlations for antibacterial agents on gram-positive and gram-negative cells.
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Alcohols↗
The use of homolytic, steric, and hydrophobic constants in a structure-activity study of 1,3-benzodioxole synergists.
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Animals↗
The use of substituent constants in drug modification.
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Animals↗
Structure-activity analysis of tetrahydrofolate analogs using sutstituent constants and regression analysis.
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Animals↗
Inhibition of malate dehydrogenase by phenols and the influence of ring substituents on their inhibitory effectiveness.
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Bromides↗
The structure-activity relationship in barbiturates and its similarity to that in other narcotics.
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Alcohols↗
Analysis of the structure-activity relationship of the sulfonamide drugs using substituent constants.
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Chemical Phenomena↗
Structure-activity relationship in the auxin activity of mono-substituted phenylacetic acids.
The analysis of substituent constants for the lipophilic and electronic factors in the auxin activity of substituted phenylacetic acids in elongation of coleoptile segments shows that these factors parallel those for the phenoxyacetic acids but assign reactivity in growth promotion to the meta position of phenylacetic acid. The inhibitory effects with supra-optimal concentrations are highly dependent on the lipophilic character of the molecules.
Phenylacetates↗
The use of substituent constants in the study of structure-activity relationships in cholinesterase inhibitors.
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Carbamates↗
Dependence of relative sweetness on hydrophobic bonding.
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Chemical Phenomena↗
The structure-activity relationship in amides inhibiting photosynthesis.
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Amides↗