Biomedical subjects

C Hagen

Publications and source records attributed to C Hagen.

At least 163 records · Page 9Linked to original sources

PubMed1975

The specificity and application of a radioimmunoassay for the alpha-subunit of luteinizing hormone in man.

A sensitive radioimmunoassay for the alpha-subunit of LH has been developed. Differences in the immunopotency of LH, FSH, and subunit preparations were found and are described in detail. The assay has been applied to the measurement of circulating levels of alpha-subunit; higher levels of alpha-subunit were found in post-menopausal than in pre-menopausal women, or men, and a rise in alpha-subunit was seen after LH-RH but not TRH administration. Elevated levels of free alpha-subunit were found in foetal cord blood at term. These results suggest that the alpha-subunit circulates independently of the intact pituitary and placental glycoprotein hormones.

Adrenocorticotropic Hormone↗

PubMed1975

Pituitary hormones in women with chronic renal failure: the effect of chronic intermittent haemo- and peritoneal dialysis.

Measurements of plasma prolactin (hPr), growth hormone (HGH), thyrotrophin (TSH), luteinizing (LH)--and follicle stimulating hormone (FSH) were performed in 20 women with chronic renal failure on regular dialysis. There was no significant difference in any of the hormone levels before and after the dialysis and no significant influence of the type of dialysis (haemodialysis and peritoneal dialysis) or the time of dialysis. Higher levels of plasma prolactin was found in the women on peritoneal dialysis than in the haemodialyzed women presumably due to the medical treatment. In the peritoneally dialyzed group four women had irregular menstruations and normal gonadotrophic levels, but elevated hPr and it is suggested that this finding is similar to that seen in the amenorrhoeagalactorrhoea syndrome, where hPr presumably in some way have antigonadotrophic actions at the gonadal level.

Adolescent↗

PubMed1975

Identification of human luteinizing hormone, follicle-stimulating hormone, luteinizing hormone beta-subunit and gonadotrophin alpha-subunit in foetal and adult pituitary glands.

Specific radioimmunoassays were used to assess the content of LH, FSH, the gonadotrophin alpha-subunit and the LH beta-subunit in four adult, 19 normal foetal pituitary glands (9-5--32 weeks of gestation) and a pituitary extract from an anencephalic foetus (36 weeks). The hormones and subunits were further identified by column chromatography on Sephadex G-100. All pituitary glands contained free alpha-subunit and intact LH but the alpha-subunit:LH ratio was significantly higher in the early foetal pituitaries (9-5--16 weeks) than in the four adult pituitaries. Only small or undetectable amounts of LH beta-subunit and 'undetectable' FSH were found in these early foetal pituitaries (9-5--11-5 weeks). The concentration of intact hormones or subunits in the pituitaries showed no significant sex difference in any of the groups. In contrast to these results, only alpha-subunit was detectable in the pituitary of the anencephalic foetus. For 14 early foetuses (age of gestation 10--16 weeks) the serum levels of LH-HCG, FSH, and alpha-subunit in the circulation were significantly higher than in 26 foetuses at term (37--41 weeks). On the basis of these results a theory for the development of the gonadotrophin secretion from the foetal pituitary gland is outlined.

Adult↗

PubMed1975