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Biomedical subjects

C Golimbu

Publications and source records attributed to C Golimbu.

At least 37 records · Page 2Linked to original sources

Computed tomography of osteoid osteoma.

Computed tomography revealed a radiolucent nidus with a surrounding zone of osteosclerosis in 17 patients with osteoid osteoma. Plain films did not reveal any abnormality in 5 patients. Conventional tomography was negative in 3 patients. Computed tomography is the modality of choice for detection of osteoid osteoma when the lesion is deep-seated or when it occurs in complex anatomic regions with curvilinear and overlapping surfaces, such as acetabulum, knee, and spine.

Acetabulum↗

Hepatocellular carcinoma with skeletal metastasis.

Three patients with symptoms related to metastases from hepatocellular carcinoma are described. The diagnosis of the primary tumor was made at autopsy in two cases and by biopsy in one. The skeletal lesions had a lytic, expansile, and hypervascular appearance. This hypervascularity may lead to bleeding either spontaneously or following biopsy. Hepatocellular carcinoma should be included in the differential diagnosis of osteolytic, expansile, hypervascular metastases, especially when such lesions are encountered in patients with liver cirrhosis.

Aged↗

Computed tomography of the sacroiliac joints: comparison with complex-motion tomography.

Forty-seven patients with sacroiliac joint abnormalities were examined with computed tomography and conventional complex-motion tomography. Twenty-nine patients had spondyloarthritis. Of the 29, complex-motion tomography detected bone erosions in 16 patients, whereas computed tomography revealed erosions in nine. Computed tomography was more sensitive in detection of joint narrowing, joint widening, osteosclerosis, and intraarticular bony ankylosis. In the remaining 13 patients, computed tomography was the modality of choice in detection of paraarticular soft tissue pathology, such as abscess or tumor, and in detection of the lesions involving the sacral canal and neural foramina.

Adult↗

Fusion of the lateral joints in fixed atlantoaxial dislocation: a computed tomography demonstration.

Fixed atlantoaxial dislocation is a well-known phenomenon that may partially account for the discrepancy between the radiographic and neurologic abnormalities seen in rheumatoid arthritis of the craniocervical region. In this care report, "arthritis rigidity" is demonstrated by computed tomography to be due to fusion of the occipitoatlantoaxial complex, following erosion and disruption of these joints by rheumatoid disease.

Arthritis, Rheumatoid↗

Fibrobullous disease of the upper lobes: an extraskeletal manifestation of ankylosing spondylitis.

Fibrobullous disease of the upper lobes of the lungs is a rare extraskeletal manifestation of ankylosing spondylitis, occurring in 1.3% of patients with ankylosing spondylitis. We present a patient with this disease, and discuss this pulmonary manifestation. Because the radiographic appearance of the chest in this disease resembles that in tuberculosis, many patients are misdiagnosed and treated for tuberculosis despite negative bacteriology. Computed tomography is useful in delineating the extent of pleural thickening, bullous changes, volume loss, parenchymal fibrosis, and bronchiectasis, as well as identifying or excluding an intracavitary pulmonary mycetoma.

Adult↗

Computed tomography of calcification and ossification of posterior longitudinal ligament of the spine.

Calcification of the posterior longitudinal ligament occurs in about 3% of adults in Japan, and in about 0.7% of hospitalized adults with spinal symptoms in the United States. The condition may be asymptomatic, however, in patients with a stenotic spinal canal or when the calcification is large, it may cause compression of the spinal cord and myelopathy. The radiographic diagnosis is made when a band of calcification is noted in the spinal canal directly posterior to the vertebral bodies. Lateral tomograms of the spine are helpful for detection and measurement of the exact thickness of the calcification. Computed tomography is particularly helpful because it reveals the thickness and the extent of lateral extension of the calcification, as well as the size of the spinal canal and the extent of its narrowing by the calcification. Seventeen patients evaluated by computed tomography are reported.

Aged↗

Quantitative computed tomography assessment of spinal trabecular bone. I. Age-related regression in normal men and women.

Computed tomography, utilized in conjunction with a calibrated phantom containing a set of reference densities (K2HPO4 and water), is capable of determining the mineral content of the trabecular bone of the spine with an accuracy of about 6% of the ash weight of the vertebrae scanned (specimen studies). Other modalities measure a composite of cortical and trabecular bone. Computed tomography is capable of exclusively measuring the mineral content of the trabecular bone of the spine, where the earliest and most pronounced changes of spinal osteoporosis occur. Quantitative computed tomography measurements are useful for a precise and objective assessment of the spinal mineral content and its changes with age, disease, and drugs.

Adult↗

Quantitative computed tomography assessment of spinal trabecular bone. II. In osteoporotic women with and without vertebral fractures.

Computed tomography was utilized to measure the bone mineral content of the spinal trabecular bone in 96 osteoporotic women. A significant overlapping was found between the values obtained for these patients and the age-matched normal values. Sixty-six percent had bone mineral content values below the fifth percentile for age-matched normals. Eighty-five percent of those with vertebral fractures had bone mineral content values below the fifth percentile for normal premenopausal women (fracture threshold). It is suggested that diagnosis of osteoporosis be made when the spinal bone mineral content value is below the fracture threshold.

Adult↗

Computed tomography of thoracic and lumbar spine fractures that have been treated with Harrington instrumentation.

Twenty patients with fractures of the thoracic and lumbar spine underwent computed tomography (CT) following Harrington distraction instrumentation and spinal fusion. CT was done to search for a cause of persistent cord or nerve root compression in those patients who failed to improve and completely recover their partial neurologic deficit (14 cases). In 6 patients seen in the late recovery period, CT was performed to evaluate the causes of pain and instability at the fracture site. Even though the image was degraded due to the artifacts generated by the metallic rods, significant information was available in each case. The most common abnormality was the presence of residual bone fragments originating in the burst fracture of a vertebral body displaced posteriorly, into the spinal canal. In patients with complications in the late recovery period, CT found exuberant callus indenting the canal or lack of fusion of the bone grafts placed in the anterolateral aspect of the vertebral bodies. This experience indicates that CT is the modality of choice for spinal canal evaluation in those patients who fail to have an optimal clinical course following fractures of the thoracic and lumbar spine treated with Harrington rods.

Bone Nails↗

Hematogenous osteomyelitis with fat-fluid level shown by CT.

Computed tomography (CT) revealed fat-fluid (pus) levels in two adult patients who had hematogenous osteomyelitis due to gram-negative organisms: in one patient within an intraosseous cavity, and in another patient within the adjacent suprapatellar bursae. Both patients were hospitalized for other chronic illnesses and had confusing clinical manifestations with non-specific radiographic changes. Observation of fluid levels, in addition to bony erosions, correctly suggested the presence of pus, and in one patient prompted a diagnostic intraosseous aspiration. To our knowledge, this CT sign of hematogenous osteomyelitis has not been previously reported.

Adult↗

CT of osteomyelitis of the spine.

Computed tomography (CT) were performed in 17 adults with osteomyelitis of the spine. The dominant features were paravertebral soft-tissue swelling, abscess formation, and bone erosion. In two patients there were no findings indicative of osteomyelitis on conventional radiographs, but CT revealed paravertebral abscesses and bone lysis, helping to establish the diagnosis of osteomyelitis. CT was found helpful in the evaluation of the patients suspected of spinal osteomyelitis, chiefly because of its ability to detect early erosion of spongy vertebral bone, disk involvement, paravertebral soft-tissue swelling or abscess, and extension of the pathology into the spinal canal. Furthermore, CT facilitated closed-needle biopsy, helping to establish the pathologic diagnosis.

Abscess↗

CT of lumbar spine disk herniation: correlation with surgical findings.

Computed tomography (CT) of the lumbar spine was performed with selectively positioned 5-mm-thick axial cross sections to examine each disk level from the top of the neural foramen to the pedicle of the next caudad vertebra. One hundred consecutive patients with 116 surgical disk explorations were reviewed. There was agreement between the CT and surgical findings in 89 patients (104 explorations) in determination of presence or absence of a herniated nucleus pulposus (HNP). Discrepancy occurred in 12 instances (11 patients): two because of incorrect interpretations, five in previously operated patients, three in spondylolisthesis, and two in spinal stenosis. There were 97 true-positives, eight false-negatives, seven true-negatives, and four false-positives. If nine previously operated patients are excluded from the study, then CT was accurate in detection of presence or absence of an HNP in 93% of the disk explorations.

Adult↗

Computed tomography of tibial plateau fractures.

Open reduction with internal fixation of tibial plateau fractures in performed frequently. Factors that must be considered in planning treatment include the patient's age and physical condition, the presence and degree of plateau depression, the presence and degree of separation of split fragments, and the severity of fracture comminution. Twenty patients with tibial plateau fractures were studied by conventional tomography and computed tomography (CT) in order to determine the role and feasibility of CT in management of such patients. CT resulted in less discomfort to the patient and provided optimal visualization of the plateau defect and the split fragments. It proved more accurate than conventional tomography in assessing depressed and split fractures when they involved the anterior or posterior border of the plateau and in demonstrating the extent of fracture comminution. Split fragments with an oblique plane of fracture also were seen better by CT. The degree of fracture depression and separation as measured by the computerized technique was often more accurate than measurements obtained from conventional tomograms. In three patients, treatment was changed on the basis of the CT findings. In three other cases, the classification was altered without a change in treatment.

Adult↗

Hypertrophic osteoarthropathy in metastatic renal cell carcinoma.

Clinical signs of hypertrophic osteoarthropathy developed in a thirty-eight-year-old man with metastatic hypernephroma. Roentgenograms of the extremities detected the characteristic periosteal reaction along the radius, ulna, metacarpals, femur, tibia, and fibula, bilaterally. The pathogenesis of this syndrome is unknown; it appears to be mediated by a pathologic reflex with the vagus nerve as the afferent limb. When seen in patients with renal cell carcinoma, hypertrophic osteoarthropathy may herald the development of intrathoracic metastases.

Adenocarcinoma↗

Computed tomography of pressure sores.

Twenty-three paralyzed patients admitted for treatment of recurrent pressure sores were evaluated by computed tomography, bone scanning, gallium scanning, and sonography. Computed tomography was helpful in detecting associated peripelvic and pelvic abscesses and pelvic osteomyelitis, which were undiagnosed by all other modalities combined in more than half of the patients. Computed tomography was also useful in preoperative planning by revealing the extent of the undermining of the pressure sore, the thickness of the fibrous scar at its base, and the size and status of the adjacent muscles.

Abscess↗

Computed tomography of traumatic serosanguineous cysts.

Two patients developed traumatic peripelvic serosanguineous cysts, following pelvic fracture. A serosanguineous cyst develops when shearing forces cause separation of the skin and subcutaneous fat from the deep fascia and muscle. The space thus created is filled with serious fluid and blood, and clinically presents as soft cystic masses, appearing usually within a day or so, or rarely, after several weeks or months. Most of these lesions resolve spontaneously, or following aspiration; however, some may persist, necessitating surgical resection. Computed tomography is the modality of choice for detection and, in those cysts requiring surgery, it is helpful in revealing the exact size and location of these lesions.

Adult↗

Use of CT-guided percutaneous bone biopsy in staging of genitourinary tumors.

CT-guided needle aspiration biopsy has been used for staging of genitourinary tumors. The display of structures provided by CT is particularly suited for complex anatomic sites such as spine, pelvis, thorax, permitting selection of the shortest and safest route for the needle, away from the aorta, vena cava, and pleural surface. Another advantage of CT is its ability to detect soft tissue components of the tumors and the presence of central necrosis therefore targetting the biopsy toward the part of the lesion with the greatest diagnostic yield.

Adenocarcinoma↗