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Biomedical subjects

C Gillberg

Publications and source records attributed to C Gillberg.

At least 199 records · Page 11Linked to original sources
PubMed1988

Infantile autism and urinary excretion of peptides and protein-associated peptide complexes.

Sixty-nine early morning urine samples obtained from three groups of young adult males (autistic, mentally handicapped, and a group of men of normal intelligence) were analyzed using the methods described by Trygstad et al. (1980). No consistent patterns of urinary chromatographic profiles were identified. A number of possible contributing factors are discussed in relation to this failure to replicate the results of previous studies.

Adult↗
PubMed1988

Oculomotor findings in autistic children.

Eleven children with infantile autism or autistic-like conditions were examined with oculomotor tests and with auditory brainstem response audiometry. Measurements of voluntary, horizontal non-predictable saccades showed that the eye motor function was abnormal in six (55 per cent) of the eleven patients. The saccades were hypometric in all six instances and the saccadic velocity was reduced in four instances. The abnormalities observed are consistent with brain dysfunction, in most cases probably indicating pontocerebellar involvement. In five instances ABR was found to be abnormal which indicates brainstem dysfunction. Oculomotor dysfunction and/or ABR abnormality was observed in eight (73 per cent) of the patients studied.

Adolescent↗
PubMed1988

Monozygotic female twins with autism and the fragile-X syndrome (AFRAX).

Identical female twins with the combination of infantile autism, mild-moderate mental retardation and the fragile-X (q27.3) chromosome abnormality are described. The case report highlights the need for chromosomal cultures in both boys and girls presenting with the "Kanner syndrome".

Autistic Disorder↗
PubMed1988

School refusal: a 15-20-year follow-up study of 35 Swedish urban children.

Results from a 15-20-year follow-up study of 35 7-12-year-old children with school refusal and 35 age- and sex-matched comparison children are reported. The school refusal cases had applied for out-patient adult psychiatric care more often than comparison children. Also they had fewer children of their own. In respect of overall social adjustment and severe psychiatric disorders requiring in-patient treatment, there were no important differences.

Ambulatory Care↗
PubMed1987

Outcome and prognostic factors in infantile autism and similar conditions: a population-based study of 46 cases followed through puberty.

This follow-up study reports data from a population-based series of children in the Göteborg region of Sweden diagnosed in childhood as suffering from infantile autism and other childhood psychoses and followed through to the ages of 16-23 years. The results of the study are in good accord with the only previous population-based study of the same kind. IQ at diagnosis and communicative speech development before 6 years were the most important prognostic factors, but other trends were seen that also compare favorably with previous studies. Some previously unreported trends also emerged.

Adolescent↗
PubMed1987

Autistic symptoms in Rett syndrome: the first two years according to mother reports.

Eight mothers of eight young Rett syndrome girls were interviewed in respect of early symptoms in the child. A questionnaire originally developed to tap early symptoms in infantile autism was used. Considerable overlap between early symptoms in Rett syndrome and infantile autism was seen, although clear differentiating features might be present already in the first few years of life.

Autistic Disorder↗
PubMed1987

Neurobiological findings in 20 relatively gifted children with Kanner-type autism or Asperger syndrome.

Seventeen children with classical Kanner autism and three children with Asperger syndrome, all of whom had Full-scale IQs above 65, were subjected to a neurobiological assessment, including CAT scan, auditory brainstem response, EEG, chromosomal cultures, cerebrospinal fluid, blood and urine examinations and a thorough physical examination. 15 of the 20 children had 'definite abnormalities' on at least one of these examinations. It is concluded that the number of cases of 'non-organic' autism, even among children with relatively higher intelligence, dwindles rapidly as our neurobiological assessment methods become increasingly sophisticated.

Adolescent↗
PubMed1987

CSF monoamines in autistic syndromes and other pervasive developmental disorders of early childhood.

Spinal fluid concentrations of the three major monoamine metabolites were examined in 25 infantile autistic children and 12 children with other childhood psychoses, and were contrasted with results obtained in normal children and in groups of children with neurological and neurodevelopmental disorders. Autistic children showed absolute and relative increases of the dopamine metabolite homovanillic acid. The group with other childhood psychoses also showed an increase in HVA level; in this group there were also indications of high levels of serotonin and norepinephrine metabolites. The results are discussed in the context of a pathogenetic model for autism involving hyperfunction of dopaminergic nerve fibres in the brain stem-mesolimbic system.

Adolescent↗
PubMed1987

Mineralization disturbances in the deciduous teeth of children with so called minimal brain dysfunction.

Exfoliated deciduous teeth from 14 children with so called Minimal Brain Dysfunction (MBD) and from 14 age-matched comparison children without MBD were collected and ground sections prepared. The sections were analysed by means of polarized light and microradiography. The enamel in ground sections of deciduous teeth from children with MBD showed a wider neonatal line than normal. The prenatal enamel showed a slight tendency to an increase in the degree of porosity, and the overall severe pathology was more common in the MBD group than in the comparison group.

Attention Deficit Disorder with Hyperactivity↗
PubMed1987

Analysis of lead and cadmium in deciduous teeth by means of potentiometric stripping analysis.

The content of lead was analysed in 101 deciduous teeth by means of potentiometric stripping analysis (PSA). In order to check possible matrix effects a limited amount of samples were analysed with atomic absorption spectrometry (AAS) as well. After weighing, the teeth were dissolved in 1M hydrochloric acid and the metal determinations were performed. The mean lead concentration was 2039 ppb w/w tooth substance. A sufficient correlation between PSA and AAS was found. A significantly higher level of lead was found in teeth from children brought up in areas of heavy traffic compared to children living in more rural areas. In conclusion the PSA technique is a reliable, sensitive and fast method for determining heavy metals in dental hard tissues. As a biproduct the corresponding figures for cadmium were achieved with a mean value of 369 ppb, however with a lower degree of confidence.

Cadmium↗