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Biomedical subjects

C Gianturco

Publications and source records attributed to C Gianturco.

At least 37 records · Page 2Linked to original sources
PubMed1985

Supraclinoid intracarotid chemotherapy using a flow-directed soft-tipped catheter.

In an attempt to avoid toxic reactions of the eye as a complication of internal carotid arterial infusion of cisplatin, carmustine, or a combination of both for the treatment of brain tumors, a new Gore-Tex/Teflon coaxial catheter system has been used for supraclinoid placement. Catheter placement was successful in 14 of 16 attempts in eight patients. Two patients experienced eye pain and conjunctivitis--a result of the chemotherapeutic agent leaking through the Gore-Tex portion of the catheter at the infusion rate of 170 ml/h. No complications were noted as long as the infusion rate was maintained at 125 ml/h or lower.

Adult↗
PubMed1985

Percutaneous endovascular stents: an experimental evaluation.

Percutaneous, expanding, endovascular stents were constructed of stainless steel wire formed in a zig-zag pattern. Stents were placed for varying periods of time in the jugular vein, vena cava, and abdominal aorta in each of five adult dogs. The dilating force of the stents could be controlled by different wire size, number and angle of wire bends, and stent length. In addition, multiple stents could be placed one inside the other or one after the other, depending on the circumstance. The stents distended the vessels and increased their diameter. No flow defects, luminal narrowing, or occlusion were noted in any of the stented vessels, even after 6 months. Side branches bridged by the stents remained patent and showed no indication of narrowing. Stent wires became encased by a proliferation of the tunica intima where they contacted the vessel wall. Encasement was slower and less extensive in the abdominal aorta. No vascular erosion or clot formation was found to be associated with any of the stents.

Animals↗
PubMed1985

Endovascular stent for use in aortic dissection: an in vitro experiment.

Injection of normal saline and contrast material into the walls of aortic specimens from human cadavers created a narrowing of the aortic lumen, simulating aortic dissection. Endovascular stents were applied to expand the aortic lumen. Successful dilatation of the narrowed aortic lumen was demonstrated in all six specimens.

Aortic Dissection↗
PubMed1985

Expandable biliary endoprosthesis: an experimental study.

Expandable stents constructed of stainless-steel wire were inserted in the extrahepatic bile ducts of five animals to determine the effect of the endoprosthesis on the ductal wall. The stents were left in place 4-23 weeks, at which time the bile ducts were inspected. The bile ducts remained patent in all animals. Relatively mild reactive inflammatory changes observed in the wall of the bile ducts were more pronounced in animals with stents in place for the longest periods. A relatively small-caliber catheter (9 French) was necessary for the introduction of the stent, which acquired a much larger diameter once it was released from the catheter. This study suggests that expandable wire stents could be safely used to relieve biliary obstruction.

Animals↗
PubMed1984

Percutaneous transcatheter filter for the inferior vena cava. A new device for treatment of patients with pulmonary embolism.

A filter for the inferior vena cava has been devised for treatment of pulmonary embolism. Percutaneous insertion of the filter is accomplished with the use of a sheath and an 8-F catheter. Therapeutic results involving 28 patients have been excellent. No embolism has recurred; no vena cava thrombosis has developed. Since minor surgery is unnecessary, the procedure saves time and is cost-effective.

Animals↗
PubMed1982

Partial splenic embolization using polyvinyl alcohol foam, dextran, polystyrene, or silicone. An experimental study in dogs.

Partial splenic arterial embolization (50% reduction in flow) was evaluated in dogs using polyvinyl alcohol foam or microspheres (20-500 mu) made of dextran, polystyrene, or silicone. Dextran and polystyrene were found to be superior for several reasons: they were easier to use, did not shatter when agitated, and produced permanent, homogeneous, peripheral occlusion with only one administration. Partial embolization with dextran or polystyrene increased platelet levels within 1 week and markedly reduced splenic size with minimal if any collateral filling within 6 weeks. Microscopically, no acute infarction or necrosis was seen at 6 weeks; there was some fibrosis, but the remaining parenchyma appeared normal.

Animals↗
PubMed1982

Preferential coronary arterial drug delivery.

A transcatheter technique for administering drugs preferentially to the canine left coronary circulation is described. The method involves pulsed, diastolic, small-volume (0.2 ml) injections through a specially designed aortic cusp catheter. In order to evaluate preferential delivery to the coronary circulation, papaverine was administered using this technique and compared to intravenous delivery. Left circumflex and carotid arterial blood flow, as well as systemic arterial pressure, were simultaneously measured. In eight of ten animals studied, diastolic aortic cusp administration of the drug for periods of up to 30 minutes increased circumflex flow an average of 136%, increased carotid arterial flow 22%, and decreased systemic arterial pressure 18%. Intravenous delivery increased circumflex flow an average of 34%, increased carotid flow 41%, and decreased systemic arterial pressure 13%. The technique has immediate research and potential clinical application as a means of preferentially delivering diagnostic or therapeutic agents, such as thrombolytics, to the coronary circulation.

Journal Article↗
PubMed1981

Complications of coil embolization: prevention and management.

From 1975 to 1980, 1,200 steel coils of three different designs were used for vascular occlusion. There were eight significant complications: Two coils were lost and retrieved, one coil was lost and remains in the pulmonary artery, four coils were misplaced to undesired sites, and one coil was fragmented and displaced during surgery. The management and prevention of these complications are described.

Embolization, Therapeutic↗
PubMed1980

A new improved coil for tapered-tip catheter for arterial occlusion.

The original coil emboli were designed for untapered-lip catheters. New coils have been designed for tapered-lip (1mm) catheters and have two helical diameters of 3 and 5 mm, respectively. The adaptation of the new coil to a tapered-tip catheter greatly simplifies its use in arterial occlusion.

Aged↗
PubMed1980

A new vena cava filter: experimental animal evaluation.

A new hypothrombogenic vena cava filter in the form of a thin (0.152mm thick) wire mesh was evaluated in 18 dogs. Each filter was inserted by the femoral vein approach with a 6.5 French Teflon catheter and left in place up to eight weeks. The vena cava remained patent in all animals, and the filters trapped all but very small (1-2mm) fragments of injection radiopaque clot. Intimal proliferation at points where the wire mesh abutted against the vena caval wall ensured stabilization of the catheter's position.

Animals↗
PubMed1979

"Mini" Gianturco stainless steel coils for transcatheter vascular occlusion.

Small stainless steel coils have been developed for transcatheter vascular occlusion procedures. The coils can be passed through a 5-French polyethylene catheter, extending the clinical applications of coil occlusion procedures for small and/or tortuous vessels. Two cases describing the use of these coils are reported.

Adult↗
PubMed1977

Transcatheter intravascular coil occlusion of experimental arteriovenous fistulas.

Fistulas were surgically created between the carotid artery and jugular vein in dogs. They were successfully occluded by means of transcatheter placement of stainless steel coils with attached woolen strands. Angiographic studies performed prior to, immediately after, and 4 weeks after occlusion were used to evaluate the efficacy of the procedure. Specimens excised 4 weeks after occlusion revealed fibrotic encasement of the coil in the fistula, forming a permanent occlusion. The technique has clinical application, and suggestions concerning its clinical use are presented based on information gained from the animal study.

Animals↗
PubMed1976

Transcatheter occlusion of abdominal tumors.

Radiological and clinical experience with transcatheter intravascular occlusion of abdominal and pelvic tumors in 55 patients is presented. Major indications include control of hemorrhage, palliation of local tumor symptoms, and preoperative management of facilitate surgery. Methods of occlusion included embolization (clot, subcutaneous tissue, and Gelfoam), introduction of a stainless steel coil into larger vessels, and balloon catheters. Hemorrhage was controlled in 8 of 12 patients with bleeding gastrointestinal and pelvic tumors. Experience in 36 patients with hypernephroma is discussed. Initial observations are presented, including occlusion of the hepatic artery for dearterialization of primary and secondary neoplasms and of the splenic artery for hypersplenism.

Abdominal Neoplasms↗