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Biomedical subjects

C Gamallo

Publications and source records attributed to C Gamallo.

At least 91 records · Page 5Linked to original sources
PubMed1990

[Importance of risk factors in the extension of pulmonary thromboembolism].

The cases of pulmonary thromboembolism (PTE) diagnosed in the clinical autopsies performed in our hospital during a 15-year period were reviewed. The incidence was 2.7% (63 cases). The most common disease associated with thromboembolism was cancer (41%). In 30 cases, thromboembolism involved more than 60% of the pulmonary circulation (group I), between 40% and 60% in 18 cases (group II), and less than 40% in 15 cases (group III). 30% of the embolisms were recurrent. A statistically significant correlation between the extension of the involved pulmonary circulation and the condition associated with thromboembolism was found. Whereas in patients with neoplasia the extension of pulmonary circulation involved by PTE was quite variable, the patients with cardiovascular disease or thrombophlebitis had PTE with invariably severe compromise of pulmonary vasculature (groups I and II).

Acute Disease↗
PubMed1990

[What factors make the diagnosis of pulmonary thromboembolism difficult?].

A series of 63 cases of fatal acute pulmonary thromboembolism (PTE) with available necropsy study was evaluated The diagnosis was established ante mortem in 20 cases (predictive index 31%). The diagnosis was only suspected in 2 of the 16 patients in whom PTE was associated with pneumonia (predictive index 12.5%, p less than 0.01), in 3 of the 26 cases if PTE associated with neoplasia (predictive index 11.5% p less than 0.01) and in 8 of the 41 cases with terminal disease (predictive index 19.5%, p less than 0.01). On the contrary, thrombophlebitis and relapsing PTE had a significative facilitation effect on the diagnosis (predictive indexes 53.3% and 52.6%, respectively; p less than 0.01). It was concluded that the presence of neoplasia, pneumonia or terminal illness make the diagnosis of pulmonary thromboembolism difficult.

Adult↗
PubMed1990

Acute chagasic cardiopathy produced by a strain of Trypanosoma cruzi (type I) in an experimental model.

We have carried out a study of the tissular tropism of the strain Y of T. cruzi considering that the different strains of T. cruzi show a great instability in their pathogenic properties with the aim of proving that the classifications of his parasite based in its tissular tropism are not reliable given that these characteristics are subject to change as can be seen by comparing our results with those of other authors. In our study, the Y. strain of T. cruzi shows a strong pancytotropic action, specially with marked cardiotropic aspects. The lack of affectation in the lymphatic ganglion and the small proportion of spleen lesions (8%) as well as the absence of pseudocysts at this level is surprising in a strain which was described as eminently reticulotropic. Our data show that this strain produces cardiac pseudocysts without lesions of the parasitized muscle fiber. The above mentioned data evidence that the biological behavior of a strain and specially its tissular tropism are susceptible to present variations with time.

Acute Disease↗
PubMed1990

Electrophysiological and anatomical findings in heart transplantation: experimental study.

The diagnosis of acute rejection by electrophysiological methods is based on the fact that signs of rejection such as inflammatory infiltrate, interstitial edema, and mostly myocyte necrosis lead to obligated alterations in electrophysiological properties of the myocardium. In a total of 276 heterotopic abdominal transplants in rats, a noninvasive monitoring of heart allograft rejection by conventional ECG and electrophysiological techniques was performed. The correlation of these findings with pathological studies, including histologic determination of the degree of acute rejection, analysis of weight and cardiac perimeter, and volumetric cell density were also evaluated in 96 of them, 66 were allogeneic and 30 syngeneic. Sensitivity and specificity of the R wave and slew rate was also determined with respect to the Billingham classification. Results of the correlation analysis showed that electrophysiological variations in R wave and slew rate correlated more intensely with changes in volumetric cell density. The greatest sensitivity and specificity was observed in R wave changes in relation to the Billingham classification.

Abdomen↗
PubMed1990

An experimental study of lymphatic vessel autotransplantation in the dog.

To provide greater insight into microsurgical treatment of lymphedema, 7 mongrel dogs underwent autotransplantation of a lymphatic collector into the contralateral lower limb. Two months later, lymphatic vessels were studied using patent blue dye, light microscopy, and histomorphometry. Patency of the transplanted lymphatics was uniformly observed although there was a notable increase in the width of the intima and a corresponding reduction in the size of the lymphatic lumen. Of note, there was a striking absence of inflammatory infiltrate at the recipient site.

Animals↗
PubMed1990

Multiple self-healing indeterminate cell lesions of the skin in an adult.

We report a case of multiple cutaneous indeterminate cell proliferative lesions in an adult without any other organ involvement. All lesions regressed spontaneously over 5 years without recurrence over a 4-year period of follow-up. The electron-microscopic and immunohistochemical features of the cellular infiltrate were those of the indeterminate cells. This case supports the hypothesis that indeterminate cell proliferative disorder is a wide spectrum of conditions with variegated clinicopathologic presentation and with different biological behavior.

Cell Line↗
PubMed1989

Anatomic findings in acute papillary muscle necrosis.

To investigate the consequences of acute papillary muscle necrosis of the left ventricle, 25 cases from a total of 133 autopsies of acute myocardial infarction were studied. Cardiac hypertrophy was found in 84%. The anterior papillary muscle was involved in four cases, the posterior in 13, and both muscles in eight. Left ventricular subendocardial infarction was found in 32% of cases. The size of left ventricular necrosis ranged from 11% to 75% of the left ventricular mass. Associated right ventricular infarction was observed in 68%. There were 19 cases of cardiogenic shock, four cases of pulmonary edema, and two cases of sudden death. We conclude that papillary muscle necrosis is usually associated with cardiac hypertrophy, posterior necrosis of both ventricles, and subendocardial infarction. Acute mitral regurgitation is probably an important contributing factor to clinical impairment and death, mostly in cases of small necrosis.

Aged↗
PubMed1989

[Design, efficiency and application of experimental methods in heart transplantation].

Heart transplantation in children with end-stage heart disease or severe congenital heart defect with uncertain surgical palliation, like the hypoplastic left heart syndrome, has become an accepted form of therapy in certain selected Medical Centers. Increasing number of heart transplantation in children have resulted from increased survival attributable to the introduction of cyclosporine. Nevertheless, the diagnosis of rejection in infants and children remains controversial being a great challenge derived by the need for repetitive and routine heart biopsies. Taking in mind that a non-invasive electrophysiologic method could be considered a promising method for monitoring heart allograft rejection the present study was begun. A total of 306 heart transplantation was performed, 206 heterotopic on rats and 30 orthotopic on dogs. Non-invasive monitoring of heart rejection was made by electrophysiologic techniques using an epicardial lead implanted on the donor heart. R wave and slew-rate measurements were performed daily at 30', primero, segundo, tercero quinto and séptimo day postransplant. These measurements were later compared to histopathologic studies. R wave and slew-rate values of alogenic or rejecting hearts were found to decrease significantly as compared to singenic or non-rejecting heart along the days. This non-invasive electrophysiologic method may be considered a promising and suitable method for monitoring heart allograft rejection.

Animals↗
PubMed1989

[Ki-1 non-Hodgkin's lymphoma. A multihospital study of 21 cases].

The Ki-1 monoclonal antibody recognizes a specific membrane antigen of activated lymphoid cells and stains large-cell non Hodgkin's lymphomas and Hodgkin's disease. Thus, it is widely used in the diagnosis of anaplastic lymphomas. Morphologically, the Ki-1 monoclonal non Hodgkin's lymphoma are diffuse of multifocal either classical or cell anaplastic type. The clinical behaviour is similar to the rest of the high grade lymphomas, disseminated at diagnosis but may reach remission after aggressive chemotherapy. The immunophenotype showed T, B or null nature of the latter. The clinical and pathological results of our study carried out in a group of 21 cases ki-1 positive lymphomas is herewith reported.

Adolescent↗
PubMed1989

[Rupture of the mitral posteromedial papillary muscle associated with myxomatous mitral valve].

We report a 52 year old man, who without previous thoracic trauma, cardiac diseases or cardiovascular risk factors presented after mild epigastric discomfort acute pulmonary oedema. He did not present clinical, electrocardiographic and biochemical manifestation of acute myocardial infarction. He was hospitalized and 15 days later he was sent to our hospital intubated and with assisted respiration. Haemodynamic studies showed severe acute mitral regurgitation and absence of significant obstructing lesions in the coronaries arteries. He was operated few hours after admission. The surgeon found a dysplasic mitral valve and rupture of a head of the posteromedial papillary muscle. The anatomopathological studies discovered mitral myxoid degeneration and ischemic lesion of the papillary muscle. We review the literature of the exclusive infarction of the papillary muscles and their possible relationships with the mitral prolapse syndrome.

Electrocardiography↗
PubMed1988

Acute right ventricular infarction secondary to massive pulmonary embolism.

Isolated right ventricular infarction has been found in cases of right ventricular hypertrophy, but there are no reports on right ventricular infarction secondary to massive pulmonary embolism. Six autopsied patients with massive pulmonary embolism and pure right ventricular infarction, suspected to be secondary to the embolism, were selected from a population of 216 autopsies. Pulmonary embolism was the suspected diagnosis in five cases due to typical clinical, electrocardiographic and haemodynamic data. Right ventricular infarction was a post-mortem finding, not previously diagnosed. In every case the thickness of the right ventricular myocardium was normal. The necrosis of the right ventricle was transmural in four cases and subendocardial in two and the entire right ventricular wall (anterolateral as well as posterior) was involved. No mural thrombi were present and in no case did the necrosis involve the left ventricle. In one case the coronary arteries were normal, in the other five significant lesions of the right or left coronary arteries were observed. These lesions may have been, in part, responsible for the necrosis of the right ventricle when the massive pulmonary embolism was added. We conclude that right ventricular infarction may be secondary to pulmonary hypertension in the setting of massive pulmonary embolism, even in the absence of right ventricular hypertrophy and with normal or stenotic coronary arteries.

Aged↗
PubMed1987

[Conventional and analytic morphometry using the IBAS-1 computer in experimental Trypanosoma b. brucei infection].

A comparative morphometrical study of the experimental infection with T. b. brucei was realized using the conventional method and the IBAS-1 analytic computer. The studied strain of T. b. brucei was preserved during 10 years in laboratory conditions, through inoculations from mice to mice. The effect of a low dose of suramin upon the percentage of different morphological forms of the parasite was analysed and compared with the untreated lots. Certain differences could be appreciated in the results of the two methods of morphometrical studies. The presence of posteronuclear, multinuclear and "stumpy" dividing forms was confirmed in our study. The administration of low doses of suramin produces a serious increase of the number of the dividing, multinuclear and "stumpy" forms.

Animals↗