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Biomedical subjects

C G Ward

Publications and source records attributed to C G Ward.

At least 19 recordsLinked to original sources

The role of Eh, pH and iron in the bactericidal power of human plasma.

The bactericidal power of fresh human plasma against Klebsiella pneumoniae and Escherichia coli was extremely sensitive to changes in Eh and pH. At a high Eh (approx. +200 mV) the bacteria were destroyed, but rapid regrowth occurred when the Eh was lowered to approx. -400 mV. Abolition of the bactericidal effect was also produced by adding ferric iron at a high Eh (approx. +200 mV). Lowering the pH to 6.50 reduced or prevented the bactericidal effect. These results are probably related to the availability of iron for bacterial growth, and could be important for understanding the development of infection in injured or diseased tissue.

Blood Bactericidal Activity

The critical role of iron in some clinical infections.

The role of iron in certain clinical infections is revealed. In normal persons the antibacterial and antifungal properties of blood and other tissue fluids cannot be maintained unless there are exceptionally low levels of available iron. This is controlled by the presence of the unsaturated iron-binding proteins, transferrin and lactoferrin. In several clinical conditions an abnormal availability of iron is responsible for fatal septicaemia. This is because the phagocytic system is overwhelmed by rapidly growing organisms when iron is freely available.

Bacterial Infections

Predictive value of historical and physical characteristics for the diagnosis of child abuse.

Child abuse by burning may be difficult to recognize, especially since the injuries are often small. Historical and physical findings that can be elicited in the initial examination can be helpful in initiating a more in-depth investigation. An injury inconsistent with the history given or a delay in seeking medical treatment were the two most frequent reports that elicited suspicion. As isolated findings, however, they had a low predictive value. The presence of two or more of 13 factors increased the yield in child abuse identification to more than 60%.

Adolescent

Burns in octogenarians.

Trauma is the fifth leading cause of death for the elderly. Approximately 7.4 million (3% of the population) are more than 80 years old (the so-called "old" old). More than 40% of Americans will reach the age of 80 years, and those who do can expect to live an average of 8 years more. The advanced elderly burn victim creates special demands because of a greater morbidity and mortality associated with a smaller body surface area burn. From September 1982 through August 1990, there were 29 patients 80 years old or older treated at our burn center. The mean age was 83 years, and 72% of the patients were women. The most common preexisting medical problems were hypertension and diabetes. Seventeen (59%) survived. The mean percentage of body surface area (BSA) burned was 6% among the survivors, with a mean length of hospital stay of 24 days. The mean BSA burned was 32% among those who died, with a mean stay of 17 days. Five of the 12 deaths were due to burns of less than 20% BSA, below the standard commonly used to define a "major" burn. The abbreviated burn severity index (ABSI) was a good indicator of survival. Eleven of 12 with an ABSI of 7 or less survived, and nine of 11 with an ABSI of 9 or more died. Twelve patients had operation; seven survived. Of the 15 survivors living independently before the injury, 11 were discharged home and four were transferred to nursing facilities. In this age group, even small burns can be problems, and indications for hospital admission should be broadened. The advanced elderly also cause financial burdens to burn centers because of inadequate diagnosis-related group (DRG) reimbursement. For those surviving, there is a good chance for maintaining independent function and for being discharged home.

Aged

A qualitative comparison of paper flowsheets vs a computer-based clinical information system.

Demonstrating the value of computerized clinical information systems (CIS) relative to its cost has been difficult. Decreased mortality in the intensive care unit or a reduction in nursing staff have not been apparent, but CIS does lead to a significant improvement in documentation over handwritten flowsheets, both in volume and accuracy. This may have a medicolegal and quality assurance impact, as well as enhancing patient care.

Burn Units

Hemochromatosis, iron and septicemia caused by Vibrio vulnificus.

Vibrio vulnificus is killed by normal human blood but grows rapidly in blood from patients with hemochromatosis. It also grows in normal blood if the saturation of the transferrin is increased or if hematin, which contains iron, is added. It is suggested that the increased availability of iron in the blood of patients with chronic iron overload is responsible for their enhanced susceptibility to infection with V vulnificus.

Female

Iron, infection, and the role of bicarbonate.

Ferric iron will not saturate transferrin in Tris buffer, and its use in experimental infections has been criticized. However, in the presence of bicarbonate, as in plasma, saturation occurs rapidly. This is comparable to natural iron overload, and infections.

Bacterial Infections

Iron and infection.

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Communicable Diseases

Suppurative thrombophlebitis: a new look at a continuing problem.

Despite knowledge of its existence and despite precautionary measures, suppurative thrombophlebitis remains a significant problem in critical care, with a reported incidence of approximately 4% and associated mortality as high as 83%. In a retrospective study, we identified additional risk factors such as emergency department or field placement of catheters and administration of potassium boluses. New guidelines for surveillance and prevention have proved successful.

Catheters, Indwelling

High-voltage electrical injuries: management and outcome of 60 cases.

High-voltage electrical injuries, though uncommon, are not rare and make up approximately 3% of hospital admissions for burns. Our review of a seven-year experience including treatment of 60 patients indicates that the mortality for hospitalized patients is low, but the complication rate is significant. Sepsis or wound infection occurred in one third and neurologic impairment in one fourth of the patients. Despite this, most patients are able to return to gainful employment.

Accidents, Occupational

Scar carcinoma arising acutely in a skin graft donor site.

Scar carcinoma is an uncommon but not rare lesion. Although generally appearing after a long latent period, an acute form exits. In this case an acute squamous cell carcinoma appeared in a skin graft donor site at about 6 weeks, and was removed at 12 weeks.

Acute Disease

Transfers from emergency room to burn center: errors in burn size estimate.

Errors in estimation of burn size are commonplace in community hospital emergency rooms. In 24 of 132 transfers to a burn center the extent of injury was overestimated at the transferring emergency room by 100% or more. This incorrect burn size estimation seems related to reliance on guesswork or use of the Rule of Nines. The incidence of error is greater in smaller burns.

Body Surface Area

Myocardial damage and electrical injuries: significance of early elevation of CPK-MB isoenzymes.

Significant cardiac complications among immediate survivors of high-voltage electrical injuries are less common than previously suspected. Transient arrhythmias predominate. The MB isoenzyme of serum creatine phosphokinase may be factitiously elevated within the first 48 hours after injury. In the absence of clinical symptoms or electrocardiographic signs of ischemia, early isolated elevation of this cardiac isoenzyme should not preclude an aggressive surgical approach.

Adolescent