Rapid weight loss in children.
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Biomedical subjects
Publications and source records attributed to C G Brook.
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Eight cases of males with persistent Müllerian structures are reported in four pairs of unrelated siblings. A genetically inherited failure to produce or to respond to the Müllerian-inhibiting substance elaborated by the fetal testis is postulated.
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Four children are described who had hypoplastic optic nerves, absent septa pellucida, and various types of endocrinological dysfunction. The importance is stressed of recognizing this syndrome and of following up the growth of the patient, because now that human growth hormone is available the short stature of some blind children may be susceptible to treatment.
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The size and number of adipose cells in obese children and adults were compared with control data. An increase in adipose cell size was found in all the obese subjects. The total number of adipose cells was increased in those children who had become obese already by the age of 1 year and in those adults who dated their obesity to childhood.
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