Search PubMed⌕ Search

Biomedical subjects

C G Brook

Publications and source records attributed to C G Brook.

At least 271 records · Page 15Linked to original sources
PubMed1978

Hypomagnesaemic hypocalcaemia with hypokalaemia caused by treatment with high dose gentamicin.

A 12-year-old boy developed renal wasting of magnesium, calcium, and potassium, with secondary hypomagnesaemia, hypocalcaemia, and hypokalaaemia (without hyperaldosteronism) after treatment with 14 400 mg gentamicin over 4 months. Gentamicin should not be given for prolonged courses if less toxic antibiotics are suitable. If it used, plasma magnesium, calcium, and potassium levels should be monitored during and after treatment.

Child↗
PubMed1978

5-alpha-Reductase deficiency causing male pseudohermaphroditism.

An infant with male pseudohermaphroditism due to deficiency of 5-alpha-reductase is described, the elder of two affected male siblings. These patients, who come from Pakistan, are the first to be described outside America.

3-Oxo-5-alpha-Steroid 4-Dehydrogenase↗
PubMed1978

Influence of nutrition in childhood on the origins of coronary heart disease.

Both the quality and the quantity of food ingested are relevant to the genesis of risk factors for coronary heart disease and the two are inseparable. Nevertheless they have a major common pathway through hypertension, which may well be the most important consequence of a high-protein, high-carbohydrate, high-fat, high-energy and high-sodium diet. Because body fatness is a strongly genetically determined characteristic and because it evolves over the whole period of childhood a vigorous and sustained programme of health education is required at all levels. The aim of such a programme is to effect a small shift in the fatness of the whole population; such a shift would dramatically and disproportionately reduce the incidence of obesity. Since the morbidity and mortality which is found in obese subjects arises primarily from cardiovascular disease in general, and coronary heart disease in particular, nutritional influences have obvious relevance to the prevention of coronary heart disease.

Adipose Tissue↗
PubMed1977

Height correlations between parents and mature offspring in normal subjects and in subjects with Turner's and Klinefelter's and other syndromes.

The correlations for stature between parents and grown-up offspring in 90 normal males and 116 normal females have been compared with similar correlations obtained in 27 adult males with Klinefelter's syndrome, 33 adult females with Turner's syndrome and in 75 adult patients with Down's syndrome. There was close similarity between the findings in the patients with sex chromosomal disorders and in normal subjects, a roughly constant amount of height being gained or lost through the chromosomal abnormalities. However the genetic pattern was lost in patients with Down's syndrome. In males with idiopathic precocious puberty and in untreated females with congenital adrenal hyperplasia, the parent-offspring correlations were not normal. In females with idiopathic precocious puberty they approximated normal values. The first two are pathological conditions of varying severity, whilst the majority of girls diagnosed as suffering from precocious puberty represent the extreme variant of normal.

Adrenocortical Hyperfunction↗
PubMed1977

Linear growth of children with limb deformities following exposure to thalidomide in utero.

The growth of 202 children exposed to thalidomide in utero and having upper (139 children) or lower (63 children) limb deformities has been assess towards the end of pre-pubertal growth. The analyses show that children exposed to thalidomide are shorter than normal children but grow at a normal velocity later. These findings may help in consideration of the mechanism by which thalidomide exerted its teratogenic effect. Analyses of growth may find a wider use in the retrospective assessment of drugs which are potentially harmful in pregnancy.

Abnormalities, Drug-Induced↗
PubMed1976

Basal stimulated prolactin levels in childhood.

Basal serum prolactin concentrations have been measured in 50 normal prepubertal children. There was no significant difference in prolactin levels between males and females and all concentrations were within the normal range for adult females (3-15 mug/l). Prolactin concentrations before and during insulin hypoglycaemia and intravenous thyrotrophin releasing hormone (TRH) have been measured in normal children of short stature, in children with isolated growth hormone (GH) deficiency and in those with hypothalamo-pituitary disease. There was no difference in either basal or stimulated prolactin levels in the normal group compared with the isolated GH-deficient group. In most of the children with hypothalamo-pituitary disease basal prolactin concentrations were within the normal range but there was an impaired response to both hypoglycaemia and TRH. Basal and stimulated levels of prolactin are compared in the same subjects with those of GH, thyroid stimulating hormone and the gonadotrophins and the clinical value of the dynamic tests described is discussed.

Adolescent↗
PubMed1975

Intestinal biopsy in the diagnosis of cow's milk protein intolerance without acute symptoms.

4 infants, suspected of cow's milk protein intolerance, were placed on an elimination diet and then challenged with cow's milk. None reacted clinically, yet in 2 of the 4 patients jejunal biopsy revealed clear histological, ultrastructural, and immunological changes. It is suggested that these changes are the objective criteria on which the diagnosis of cow's milk intolerance should be based, and that the clinical evidence derived from milk challenge after an elimination diet may be unreliable.

Biopsy↗
PubMed1975

Influence of heredity and environment in determination of skinfold thickness in children.

Triceps and subscapular skinfold thicknesses were measured in 222 pairs of like-sex twins (78 monozygotic and 144 dizygotic) aged 3-15 years. Log transformations of the measurements were standardized for age and sex and the results used to estimate heritability--that is, the proportion of total variation determined by genetic factors. The overall contribution of non-genetic familial effects was small. There were appreciable differences in heritability between limb and trunk fat and between the sexes and at different ages. Over the age of 10 heritability was high for both sites in boys and girls. In younger children environmental factors contributed more to the variation.

Adolescent↗