Biomedical subjects
Publications and source records attributed to C Freeman.
Four participants in a roundtable discussion examined the specific grievance procedures of a nonunionized, not-for-profit, medium-sized hospital and of a partially unionized, not-for-profit, large teaching hospital. In doing so, they also raised questions, considerations, and guidelines that may be of interest to hospitals that already have or that are planning grievance procedures.
Aboriginal children who were aged from six to nine years and living in Cherbourg Community were treated for Giardia Lamblia and Entamoeba histolytica infection with either the manufacturer's recommended dose of metronidazole (Flagyl) or with tinidazole (Fasigyn), at two-dose levels. Tinidazole successfully cleared both protozoans from stools, a single dose being as effective as the longer regimens which were studied. The obvious advantage of single-dose administration is that it should permit more effective treatment of these intestinal parasites, especially in Aboriginal populations.
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The pattern of change in the concentration of immunoreactive insulin in portal vein blood during a 7-hour period following intragastric administration of glucose to fasted, male Sprague-Dawley rats is modified both in magnitude and time course of response as rat age increases from 2- to 24-months. This alteration in the control of insulin levels probably is not the consequence of modifications in the availability of administered glucose to the pancreas. A similar modification in the control of insulin secretion also is evident when pancreatic islets isolated from fasted rat donors aged 2- to 24-months are perifused with glucose in vitro. This may represent the first demonstration of an altered response of aging animals which is expressed in the same way in an isolated in vitro system.
The MMPI was administered to 36 male low back pain patients at the Seattle Veterans Administration Hospital. The patients were divided into three groups of 12 each. The organic group contained patients who had an organic basis for their pain. The functional group contained patients who had no organic basis for their pain. The mixed group contained patients who had some organic basis for their pain, but one that was thought to be insufficient to account for the pain they were reporting. The mixed and functional groups differed significantly from the organic group on the Hs, Hy, Pt, Sc, Hy-O, D-O, and DOR scales. The mixed and functional groups differ significantly from each other only on the Hy-O scale. The special low back pain scales of Lb and DOR were found to have little utility when used separately. When used in conjunction, however, the scales discriminated correctly 75% of the time.
The potential utility of the MMPI 168 with two inpatient medical populations was explored in the present study. Correlations and clinically relevant comparisons suggested that the MMPI 168 predicted the standard MMPI with a high degree of accuracy.
We used sonography to investigate 3 patients with hypertension owing to a Page kidney phenomenon. In 2 cases a perinephric cystic collection was compressing the kidney, while in 1 case there was a large perinephric organized hematoma. When a Page kidney is suspected in a hypertensive patient sonography is a reasonable next step in the evaluation, after the excretory urogram, and may obviate the need for angiography.
A patient with uncontrollable postoperative renal hemorrhage was successfully treated by sub-selective injection of autologous clot into the renal artery. Followup arteriography 10 days later revealed persistent occlusion of the bleeding vessel with recanalization of all other vessels. This method is an effective alternative to an operation in cases of renal hemorrhage of diverse etiology not responsive to conservative management.
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A case of malignant pheochromocytoma of the bladder associated with renal cell carcinoma is described. The necessity for long-term followup in such cases is stressed. This case provides further documentation of the association of pheochromocytoma with renal cell carcinoma, an association which may occur more frequently than would be dictated by chance alone. It is suggested that these cases may represent von Hippel-Lindau disease with incomplete penetrance.
A new procedure developed in animals has been applied to produce male human sterilization. This involves the percutaneous injection of an ethanol and formaldehyde solution into the vasa deferentia. An initial clinical trial of eight human volunteers indicates that this is an effective method of producing male sterilization.
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