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Biomedical subjects

C Frances

Publications and source records attributed to C Frances.

At least 91 records · Page 5Linked to original sources
PubMed1990

Skin thickness changes in normal aging skin.

The age-dependent decrease of skin thickness was studied with a morphometric procedure on upper inner arm skin biopsies. Epidermal thickness decreased somewhat faster in men (7.2% of the original value/decade) than in women (5.7%). The total dermal thickness decreased at about the same rate in men and women (6%/decade). The thickness of the superficial layer of the dermis exhibited a biphasic evolution with age and these variations were not significantly different between men and women because of the large individual variations. This may be due partially to the difficulties of delineating with precision the limit between superficial and reticular dermis. These results are somewhat lower than those obtained by physical measurements of skin thickness. This may be due to fixation artifacts and also to the overestimation of skin thickness by physical measurements.

Age Factors↗
PubMed1989

[Idiopathic white atrophy causing cutaneous thrombotic microangiopathy. Apropos of a case].

Authors report clinical data on a 59-year-old woman, bearing, since 15 years, painful purpuric and necrotizing macules and papules on the legs, leading to white atrophic scars. On examination one could see lesions in various stages of development. Clinical examination and all laboratory investigations were otherwise normal. First cutaneous biopsy led to an erroneous diagnosis of vasculitis with subsequent corticotherapy. Second biopsy displayed numerous fibrinous thrombi inside lumens of superficial dermal capillaries without fibrinoid necrosis of their parietal layer nor inflammatory infiltrate. A diagnosis of white atrophy was made on the coexistence of clinical and histopathological data, according to Shornick's criteria. Drastic improvement of clinical condition was obtained with heparin therapy. White atrophy is a clinicopathological entity first described in 1929 by Milian, then by Nelson in 1955. Authors describe here its main clinical data with diagnostic considerations and pathophysiology.

Atrophy↗
PubMed1988

[Ambiguous keratosis. The situation of leukoplasia of the oral cavity].

The terminology used for white lesions of the oral cavity requires careful definition: the term keratosis is general, covering all lesions which by histological examination show evidence of keratin on the surface, regardless of other detectable lesions; the term leukoplasia is more restrictive, indicating (according to the WHO) white lesions not falling within the context of a known disease = lichen, lupus erythematosus, florid oral papillomatosis, chronic candidiasis, etc. This review chose the diagnostic difficulties of different varieties (planus, warty, erosive) of leukoplasia. In our experience the ambiguity of keratosis may be due to inadequate data from clinical examination and/or histological examination, to the combined existence in a given patient and at the same time of two white lesions of different nature, or to the successive existence at the same place of two lesions with a different clinical and/or histological diagnosis (raising the problem of transformation).

Adult↗
PubMed1986

Systemic infections with Trichosporon beigelii (cutaneum). Report of three new cases.

Three new cases of systemic mycosis due to Trichosporon cutaneum are reported and compared with the 23 previous reports. Two patients had acute leukemia and one patient had a lymphoblastic lymphoma. Blood cultures in two patients and cerebrospinal fluid in the third patient were positive for T. cutaneum. Only one patient recovered after antimycotic therapy and concomitant remission of his leukemia. At autopsy, the two other patients showed widespread infection with T. cutaneum. The authors conclude that diagnosis and management of such infection in the immunosuppressed host are difficult and the prognosis is poor.

Adult↗
PubMed1986

[Angiolymphoid hyperplasia with eosinophilia (Kimura's disease). Apropos a case report with ultrastructural and histoenzymological study].

One case of angiolymphoid hyperplasia with eosinophilia is related in a 30-years old woman. This observations has all the characteristics of the disease: telangiectasic oedema, nodules and infiltrated areas located in the cervico-facial skin and also in the nasal and buccopharyngeal mucosa. Histologically, the proliferation is made of adult or young capillaries surrounded by inflammatory cells. The results of the peculiar morphological methods used here prove the endothelial nature of cells: high enzymatic activities of alkaline phosphatase and ATPases; factor VIII present on the cells; ultrastructural features characteristic of more or less differentiated vessels. Besides their nosologic interest, these methods may be useful for the diagnosis of this disease with the other vascular tumors.

Adult↗
PubMed1985

[Vulvovaginogingival syndrome. New characteristic grouping of plurimucous erosive lichen planus].

The triple association of a chronic painful erosive vulvitis, an erosive or desquamative vaginitis and an erosive vestibular gingivitis constitutes a hitherto unreported syndrome. The first 19 cases of this affection seen in the Hôpital Tarnier over the last three years are presented and analyzed, the etiology of these erosive mucosal lesions, limited to three body regions, being lichen planus in each case. Detection of mucosal erosion at one of these three sites now requires clinical investigation of the other two, and biopsy of least one of them from the edge of an eroded zone, as well as search for other-possible mucocutaneous areas of lichen planus. Clinical onset is often asynchronous, one lesion appearing before the others, the simplest to recognize being gingival erosive lichen. In one case, however, peri-erosive lamellar detachments suggested chronic desquamative gingivitis of possible benign pemphigoid origin. Erosive lichen planus of vulva and vagina has not been reported previously. Knowledge of this syndrome allows correlation between lichen planus and certain cases of erosive gingivitis, erythroplastic vulvitis and desquamative vaginitis.

Adult↗
PubMed1985

[Collagen diseases and microcirculation].

The microcirculation (terminal vessels with a calibre of less than 30 mu) was examined by means of capillaroscopy which was correlated with histological studies. According to the classification of vasculitis, microvasculitis is a pathological process involved in a number of collagen diseases. The study of the cutaneous lesions of leukocytoclastic angiitis is one of the best method for approaching the study of these microangiopathies, especially in the context of hypersensitivity vasculitis. The study of the microcirculation may also be valuable in other connective tissue diseases (various forms of necrotic vasculitis, lupus, scleroderma, polydermatomyositis) and in Behçet's disease. However, this study is only in its preliminary stages and the data of capillaroscopy need to be interpreted critically.

Capillaries↗