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Biomedical subjects

C Feldman

Publications and source records attributed to C Feldman.

139 records · Page 8Linked to original sources
PubMedDate not supplied

Abdominal findings in AIDS-related pulmonary tuberculosis correlated with associated CD4 levels.

BACKGROUND: To document the abdominal manifestations of tuberculosis (TB) associated with human immunodeficiency virus (HIV) infection and to correlate those findings with CD4 levels. METHODS: Twenty-nine HIV-positive patients with culture-proven Mycobacterium tuberculosis infection were entered into the study. Chest changes were used to separate patients into two groups: those with and those without evidence of previous TB. All patients had standard chest radiographs, routine and high-resolution chest computed tomography (CT), and abdominal ultrasound examinations. Twenty-four patients had abdominal CT scans. RESULTS: The group of patients with no previous radiographic evidence of pulmonary TB had a significantly greater tendency to have manifestations of pulmonary and/or abdominal miliary dissemination. Those patients with radiological evidence of miliary dissemination were significantly more likely to have CD4 counts of less than 300. CONCLUSIONS: Chest and abdominal miliary dissemination of TB in HIV-positive patients is significantly associated with radiologically determined primary onset pulmonary TB. These changes occur predominantly at CD4 counts of less than 300.

AIDS-Related Opportunistic Infections↗
PubMedDate not supplied

Acetate levels in human plasma.

We have developed a gas liquid chromatographic assay for plasma acetate which detects 0.01 mM and has a standard deviation of less than 16% of the mean at 0.05 mM. The acetate concentration of venous blood obtained from normal subjects was 0.025 +/- 0.002 mM. The value was not significantly different from the venous acetate concentration of dialysis patients, prior to a dialysis treatment. The acetate concentration of arterial plasma obtained from dialysis patients prior to a hemodialysis treatment was 0.048 +/- 0.006 mM. This was significantly greater than the venous concentration of 0.027 +/- 0.002 (p less than 0.01). This arteriovenous difference suggests that acetate is utilized peripherally. At the onset of hemodialysis, acetate concentrations rapidly rose and, in all but one case, reached a steady state value in the range of 1.5-5.1 mM. At the termination of dialysis, acetate concentrations fell rapidly, usually achieving baseline values within one hr. The rate of decrease was not a simple logarithmic function, suggesting that acetate metabolism is not solely a first order function. Furthermore, acetate disappearance was more rapid in the dialysis patients than in the normal subjects. We wish to emphasize that the present data, which were obtained on a small number of subjects are preliminary and should be interpreted with caution.

Acetates↗
PubMedDate not supplied

Perinephric abscess: report of 19 cases.

Nineteen patients with perinephric abscess were treated during a period of ten years. Eighteen abscesses were cured by drainage performed as soon as the diagnosis had been made. One patient died because the correct diagnosis had not been reached, the correct one being revealed by autopsy. Staphylococcus and gram negative bacilli were equally isolated. Stones were present in thirteen patients. Forty-two per cent of the patients were diabetic. The literature is reviewed.

Abscess↗