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Biomedical subjects

C Feldman

Publications and source records attributed to C Feldman.

At least 127 records · Page 7Linked to original sources

Comparison of the effects of atropine and glycopyrrolate on pulmonary mechanics in patients undergoing fiberoptic bronchoscopy.

The effects of atropine and glycopyrrolate on forced vital capacity (FVC), forced expired volume in one second (FEV1), the FEV1/FVC ratio, and peak expiratory flow (PFL) were compared in 44 patients undergoing fiberoptic bronchoscopy under general anesthesia. Both anticholinergic agents improved pulmonary function equally before general anesthesia, but in both groups there was a small and again equal deterioration in pulmonary function after the procedure. The protective effects of the two drugs were not significantly different. Because of the lower incidence of undesirable side effects, glycopyrrolate is recommended as the anticholinergic agent of choice for bronchoscopy.

Atropine↗

Gallstones and diet in Tel Aviv and Gaza.

To study the possible association between diet and gallstones we investigated these two variables in two populations in Tel Aviv and Gaza with presumed differences in both. Gallstones were more frequent in Jews in Tel Aviv than in Arabs in Gaza, 12.1% versus 3.8% (p less than 0.001). This difference was fully accounted for by the 60+ age groups in both populations. There were no significant differences in the frequency of gallstones among the 20-39 and 40-59 age groups. Numerous and marked differences in diet composition were found between both populations. Energy, carbohydrate and fiber intake was higher in Gaza. The consumption of unsaturated fats was greater in Gazans and their P/S ratio was higher, 0.92 versus 0.70 in Tel Aviv. Beef and fish were usually eaten in Gaza while poultry was more frequently consumed in Tel Aviv. There were also differences in vitamin and mineral consumption. It cannot be determined which, if any, of these dietary differences is related to the lower frequency of gallstones in the older population of Gaza. Alternatively it could be the diet eaten in Gaza many decades ago, presumably poorer in protein and fat, which is responsible for these differences.

Adult↗

Femoral mycotic aneurysm presenting as arthritis and purpura.

A case is described with recurrent arthritis and skin rash confined to the right lower limb and exacerbated on each occasion by exercise. Investigation established this to be due to a mycotic aneurysm of the right common femoral artery. Treatment with excision and grafting and antibiotics resulted in full recovery. Mycotic aneurysm and the unusual presenting features in this case are discussed.

Aneurysm, Infected↗

An increased familial frequency of gallstones.

Despite the very high prevalence of gallstone disease, studies of familial factors are very few, and asymptomatic family members were not studied. We studied, in a prospective manner, the frequency of gallstones in 171 first-degree relatives of patients with proven gallstones compared with 200 matched controls. All subjects were studied by oral cholecystography, and their height, weight, blood glucose, cholesterol, and other parameters were measured. Gallstones were found in 20.5% of the family group and in 9.0% of the control group. Gallstones were found in 22.8% of the female and 16.7% of the male family members as opposed to 10.3% of the female and 8.0% of the male controls. All these differences were statistically significant. Known risk factors, such as Ashkenazi community group, higher age, and overweight, were more frequent in the control group, as were blood glucose and cholesterol. These findings strengthen the validity of the twofold higher frequency of gallstones found in the family group and are likely to be due to genetic factors. A formal genetic family study of gallstone disease is now indicated, using the ultrasonic method.

Adult↗

Phaeochromocytoma. Case reports.

Three cases of phaeochromocytoma are described. Several clinical manifestations are highlighted. The biochemical diagnosis, tumour localization and management are discussed. Surgical removal of these tumours has resulted in the cure of symptoms and hypertension in these 3 cases.

Adrenal Gland Neoplasms↗

Toxic epidermal necrolysis in a patient treated with gold salts and benoxaprofen.

Fatal toxic epidermal necrolysis is described in a patient, treated concurrently with sodium aurothiomalate and benoxaprofen, who had previously had these two drugs separately, with only minor mucocutaneous problems while on gold, and no adverse effects from benoxaprofen. It is suggested that benoxaprofen could act synergistically with gold, resulting in enhancement of mucocutaneous side-effects, which are common to both these drugs.

Aged↗

Experience with acute poisoning in an intensive care unit. A review of 103 cases.

We present our experience with 103 adults with acute poisoning severe enough to warrant admission to the Medical Intensive Care Unit (MICU) of the Johannesburg Hospital. They comprise only 6,1% of all adult cases of poisoning admitted to the hospital during the same 3-year period. The mortality rate was 5,8%. Active support of vital functions is the focal point of therapy and will ensure a favourable outcome in the majority of cases.

Adult↗

Chronic sarcoid arthritis.

Sarcoidosis can involve almost any organ or tissue. The outcome may be clinical recovery with radiographic evidence of residua, impairment of function of organs involved, or a continued chronic course. This report is a patient who presented with chronic sarcoid arthritis without evidence of active disease in other organs, 20 years after sarcoidosis had been diagnosed. The clinical picture superficially resembled rheumatoid disease with keratoconjunctivitis sicca and basal lung fibrosis.

Arthritis↗