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Biomedical subjects

C Evans

Publications and source records attributed to C Evans.

At least 253 records · Page 14Linked to original sources
PubMed1980

Zinc65 absorption in patients with carcinoma of the prostate.

The intestinal absorption of 65 Zn was determined in patients with carcinoma of the prostate prior to treatment and during estrogen therapy. Following an oral tracer dose of 65 ZnCl2, plasma levels and urinary and fecal excretions of 65 Zn were determined. The absorption of 65 Zn was low in six of eight patients, particularly in three patients who had extensive metastatic bone involvement. During estrogen therapy the absorption of 65 Zn increased markedly in these patients, and this increase correlated with the clinical remission of the neoplastic process. In one patient who did not respond to estrogen therapy, 65 Zn absorption was normal prior to treatment and did not increase during estrogen therapy. In patients free of neoplasia estrogen administration did not increase 65 Zn absorption, and even decreased it. These results indicate that the intestinal absorption of 65 Zn is decreased during the active phase of carcinoma of the prostate and improves during clinical remission induced by estrogen therapy.

Aged↗
PubMed1979

The effect of prostatectomy on urodynamic parameters.

Sixty per cent of men subjected to prostatectomy had unstable bladders. It was found that this was related to the presence of either an indwelling catheter or obstruction, but had little influence on the result of prostatectomy. The functional urethral pressure profile length did not correlate with the size of the prostate gland. Shortening of the prostatic plateau was always found, but the extent to which the plateau was reduced did not correlate with urine flow rates.

Adult↗
PubMed1978

Synthesis of myosin heavy and light chains in the afterloaded guinea pig right ventricle.

Increased afterload causes increased cardiac myosin synthesis and ultimately leads to hypertrophy. Since the latter is associated with altered myosin ATPase activity, it was of interest to study the synthesis of myosin subunits in the acute response to this stress. An in vitro guinea pig heart preparation was used which allowed application of afterload to the right ventricle with unaltered coronary flow, and also permitted measurement of synthesis of myosin heavy chains (HC) and combined light chains (LC) by continuous perfusion with labelled amino acids (3H-lysine and/or 3H-phenylalanine) of constant specific activity. Isolation of 3H-labelled HC and LC with heterologous unlabelled carrier was possible because of identical mobilities of HC's and LC's from unlabelled lamb carrier myosin and 3H-labelled guinea pig myosin. This permitted study of comparative synthesis of the HC and LC in small samples as the single guinea pig right ventricle (100--150 mg) and avoided errors inherent in pooling hearts or in measurement of turnover in the nonsteady state. After 3 h or perfusion, the ratio of synthesis of HC/LC was 2 : 1 in controls. This ratio increased significantly to 3 : 1 in after load. It is possible that the disproportionate increase in HC synthesis may lead to stoichiometric problems in myosin assembly which ultimately effect altered myosin ATPase activity.

Animals↗
PubMed1975

Chemonucleolysis.

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Chymopapain↗
PubMed1975

An appraisal of peritoneal lavage in the diagnosis of the acute abdomen.

Forty-seven selected patients presenting with acute abdominal symptoms were investigated by examination of the fluid obtained by peritoneal lavage. In 34 patients this confirmed the clinical diagnosis, in 11 it was a more positive help in that it corrected an erroneous clinical diagnosis and in 2 the results of the investigation were misleading.

Abdomen, Acute↗
PubMed1975

The effect of pressure or flow stress on right ventricular protein synthesis in the face of constant and restricted coronary perfusion.

Cardiac stress produced by hypertension or excess volume loading results in different types of hypertrophy. Elevated left ventricular pressure rapidly results in increased myocardial protein synthesis in vivo and in vitro, but such rapid alterations are not consistently seen in volume loading. The difference in response is difficult to clarify since it is not possible to effect alterations in left ventricular pressure or perfusion without profoundly affecting coronary perfusion. The present study describes cardiac protein synthesis in the right ventricle of the young guinea pig heart in vitro by utilizing a perfusion model in which the right ventricle could be stressed by elevations of pressure or volume loading in the presence of constant and restricted coronary perfusion. With coronary flow maintained at 4 ml/min per heart equivalent to 25 ml/min/g dry wt, an increase in right ventricular pressure from normal levels of 3 mm Hg to 11 mm Hg resulted in a 60 percent increase of myocardial incorporation of (14C)lysine into protein. However, with further increases of right ventricular pressure to 22 mm Hg, protein synthesis dropped back to normal levels. The falloff in protein synthesis was not due to decreased contractility, alterations in intracellular lysine pool specific activity, or alterations in distribution of coronary flow. a 60 percent increase in coronary perfusion was again associated with a similar response of protein synthesis to progressive elevations of pressure despite a rise in the ATP levels and a fall in lactate production. Thus, a deficiency of O2 did not entirely explain the decline of protein synthesis with maximal pressures. At all levels of coronary perfusion, volume loading for 3 h did not result in increased protein incorporation of (14C)lysine. The studies support a relationship between ventricular pressure and protein synthesis unrelated to coronary flow per se. A pressure receptor triggering protein synthesis within the ventricular wall is postulated. Such a relationship is not apparent in short-term volume loading in vitro.

Adenosine Triphosphate↗
PubMed1974

The incidence and causes of postoperative jaundice. A prospective study.

Jaundice often complicates recovery after surgery. We have studied 180 patients undergoing 218 major operations and found an incidence of 3.7% severe jaundice and 16.5% mild jaundice. The causes of the jaundice were diverse, but the most important was a bilirubin overload (primarily from blood transfusion) which could not be excreted effectively by a liver whose cellular metabolism was disturbed. We found no evidence of a relationship between halothane and liver damage.

Adult↗