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Biomedical subjects

C E Anderson

Publications and source records attributed to C E Anderson.

82 records · Page 5Linked to original sources
PubMed1968

Efficiency and the public's health.

The Governor's Survey on Efficiency and Cost Control, established by Governor Reagan's executive order, was a non-profit, bipartisan, privately financed management analysis of State administration conducted by private citizens, including physicians, during 1967 for the purpose of achieving improvement in administrative procedure and operating economies in State government. State employees and appointed department heads offered many valuable suggestions and cooperated fully with the survey team. Two hundred recommendations were submitted to the Governor for improvement in the Departments of Public Health and Mental Hygiene, the Office of Health Care Services and the organizations under the Secretary of Human Relations.The recommendations for the health-related administrative units concerned reorganization and consolidation of departments and units, improvement in administrative and operating methods and improvement of services. Annual savings of several hundred million dollars could result. None of the recommendations were for reduction in services and none concerned individual employees or appointees. Assistance in and support for the implementation of the recommendations will be needed from legislators, responsible citizens and organizations interested in efficient and economical government.

California↗
PubMedDate not supplied

Extra structurally abnormal chromosomes (ESACs)--presentation of 10 new cases.

BACKGROUND: The goal of the presented studies as a retrospective reliability assessment of classical banding cytogenetic studies and of prognosing epicrises in a group of 14 cases, affected with additional marker chromosomes. MATERIAL AND METHODS: Having collected the study material from peripheral blood, by means of trophoblast biopsy or amniocentesis, cytogenetic preparations were obtained, allowing for pre- or postnatal evaluation of the karyotype. A panel of auxiliary cytogenetic techniques accompanied the routine CTG protocol. RESULTS: In a group of 6875 persons with recommendations to pre- or postnatal cytogenetic diagnostics, 14 (0.2%) cases of ESACs were diagnosed. In 5 cases of DA/DAPI(+) inv dup (15) as observed. A presence of polymorphic interstitial RHG(+) band was found within the marker chromosome. The measured size of that band allowed associating it with either the presence or the absence of pathological signs. In 9 cases of ESACs, DA/DAPI(-), the application of banding techniques (NOR and CBG) allowed to discover bisatellite heterochromatic ESACs in 6 cases (2 non-mosaic and 4 mosaic). In three other mosaic and non-satellite cases of ESACs, a 'genetic inactivity' of the marker chromosome was observed in one case, while a 'genetic activity' was ascertained in two cases. The 'activity' of marker chromosomes was studied by means of replication banding techniques. CONCLUSIONS: At the time of the outburst of molecular techniques, still up-to-date is the use of classical banding techniques and of the replication techniques, allowing DNA replication kinetics studies at the level of single band.

Adolescent↗
PubMedDate not supplied

Conditioned taste aversion following acutely administered acrylamide.

Fischer-344 rats were acclimated to a daily 15 min period of water availability. After water consumption had stabilized, the rats were permitted a 15 min access to 0.15% (w/v) solution of saccharin. One to two min following saccharin presentation, they were given various doses of acrylamide (10-50 mg/kg) or lithium chloride (LiCl; 3 mEq/kg) by gavage. Three days later, aversion to the saccharin solution was determined. Acrylamide, like LiCl, produced an aversion to saccharin. The effect of acrylamide appeared to be dose-related with the threshold dose being 10 mg/kg.

Acrylamides↗