Search PubMed⌕ Search

Biomedical subjects

C Dupuis

Publications and source records attributed to C Dupuis.

At least 109 records · Page 6Linked to original sources
PubMed1979

Quantitative determination of plasma oxyphenbutazone by gas-liquid chromatography with selective nitrogen detection.

A sensitive and specific gas chromatographic method, using the nitrogen-phosphorus detector for the detection and determination of oxyphenbutazone extracted from plasma is described. The method involves extraction and back-extraction steps followed by derivatization of both oxyphenbutazone and the internal standard with trifluoroacetic anhydride. The procedure permits the rapid and specific routine determination of oxyphenbutazone in plasma with a detection limit of 0.5 microgram/ml. The procedure is linear over the range of concentrations encountered after administration of a single oral therapeutic dose. No interference from the biological matrix is apparent. The suitability of the method for the analysis of biological samples was tested by studying the variation with time of oxyphenbutazone plasma concentrations in normal human volunteers over a period of several biological half-lives.

Autoanalysis↗
PubMed1979

[Acquired pulmonary atresia complicating tetralogy of Fallot].

Pf 51 cases of Fallot's tetralogy who underwent preoperative angiography before a palliative anastomosis and then a second angiography before complete correction, 10 had developed pulmonary atresia (infundibular in 8 cases, valvular in 2 cases). The type of anastomosis (Blalock-Taussig of Waterston), and the interval between the two operations do not seem to be determinant factors. The initial severity of the stenosis seems to favour the development of atresia but this is not invariable. The authors discuss the aggravating role of the anastomosis and the consequences of this type of complication.

Adolescent↗
PubMed1978

[Health assessment of managers 63 and 64 years old. (Results of the first step of a prospective study on the adaptation to retirement) (author's transl)].

A cross-sectional study has been carried out on a group of 180 male preretired managers and top executives in order to investigate their health status. This study is the first part of a longitudinal survey undertaken to analyze the adjustment to retirement among managers. These 180 subjects were 63 or 64 years old, still working at full time. The study included a standardized medical questionnaire, a medical examination as well as various biological, physiological and psychological measurements. For each main ICD categories of diseases, the prevalence rate was assessed; for each subject two indices of global morbidity were established. Furthermore, some risk factors of cardio-vascular diseases were assessed.

Adaptation, Psychological↗
PubMed1978

Nanogram-range determination of plasma imipramine by gas-liquid chromatography using a selective nitrogen/phosphorus detector.

A sensitive and specific gas chromatographic method for the quantitative determination of plasma concentrations resulting from a single normal therapeutic dose of imipramine has been developed and is descriged. After extraction into a mixture of n-heptane/isoamyl alcohol (98.5:1.5), imipramine is well separated from its main metabolite, desmethylimipramine, and both compounds are detected using a selective detector operating in the N/P mode. The procedure permits the rapid routine quantitative analysis of relatively small plasma volumes (1-2 ml) containing as little as 1-2 ng of imipramine. No interference from the biological matrix is apparent. The suitability of the method for the analysis of biological samples was tested by studying the time of course of imipramine plasma concentrations in normal human volunteers, after administration of a single therapeutic dose.

Chromatography, Gas↗
PubMed1978

[The heart diseases of children born to alcoholic mothers].

The authors present their experience of heart disease in children with congenital abnormalities of alcoholic origin, of which they have seen 50 cases in 3 years. This syndrome, which was first described by Lemoine in 1968, appears to be fairly common. It shows the teratogenic properties of alcohol. It is characterised by facial abnormalities which are easy to recognise, gross failure to gain in height and weight, psychomotor retardation of varying severity and several other malformations. From amongst these, cardiac malformations are the most commonly encountered. These are usually in the form of septal defects (atrial and ventricular septal defects).

Abnormalities, Multiple↗
PubMed1978

[Echocardiography in Ebstein's anomaly. Apropos of 12 cases].

The authors report 12 cases of Ebstein's disease, and have studied the echocardiographic findings in these cases. The results have been compared with those of a control series of 12 patients with an atrial septal defect and a large shunt effect. There are only two conditions which are important in the diagnosis of Ebstein's disease: the finding of the tricuspid valve beyond the midclavicular line, and a delay in the closure of the tricuspid valve greater than or equal to 0.06 seconds when compared with the mitral valve. Using these two criteria, the diagnosis could be made by echocardiography in 10 cases out of 12.

Adolescent↗
PubMed1977

Isolated ventricular discordance and complete atrioventricular canal in situs inversus. Report of successful surgical repair.

Isolated ventricular discordance is a very rare malformation, most often lethal in the first months of life. A patient with this lesion survived to age 9 years in spite of the coexistence of a complete form of atrioventricular (A-V) canal. Surgical repair with a Mustard procedure was associated with correction of the endocardial cushion defect. Situs inversus itself caused no problem. Although permanent complete A-V block occurred, the result has been satisfactory so far. This case is thought to be the first successful correction of this malformation.

Child↗
PubMed1977

Radioimmunoassay of anabolic steroids: an evaluation of three antisera for the detection of anabolic steroids in biological fluids.

Recently developed radioimmunoassays (RIA) for the analysis of anabolic steroids and their metabolites in biological fluids were tested for cross-reactivity with other types of steroids. Results show that the degree of desirable cross-reactivity within the two classes or orally active anabolic steroids vary widely and that the antiserum for 19-Nortestosterone (the active principle of intramuscular preparations) has a very high degree of undesirable cross-reactivity with components of oral contraceptives. Single and multiple dose studies in human volunteers demonstrate that the detection level and degree of retrospectivity are likewise variable but that the test easily detects most anabolic steroids during treatment. At the present time, the combination of the three antisera for the assay of a sample appears to be a relatively rapid and economic method for screening large numbers of samples in situations where doping control of anabolic steroids is required. The importance of utilizing physico-chemical means for identification of RIA potential positives is emphasized.

Anabolic Agents↗
PubMed1977

[Lack of attachment of the superior vena cava to the mediastinum. Apropos of 2 cases].

Two cases in which the superior venae cavae ran an extramediastinal course are presented. This abnormality, which was discovered on catheterisation, had no haemodynamic consequences. It consisted of two superior venae cavae with little or no intermediate trunk; this explains the lack of attachment' of the superior venae cavae to the mediastinum.

Cardiac Catheterization↗
PubMed1977

[Cerebral abscess due to abnormal caval return].

A case of abnormal venous return is reported. It was discovered during investigation of a cerebral abscess. There was a persisting and unique left superior vena cava, draining in the left atrium. No other cardiac malformation was present. This abnormality is rare as only 2 other cases have been reported. It should be suspected in children presenting with cyanosis, clubbing of the fingers and left ventricular hypertrophy on electrocardiography.

Brain↗
PubMed1976

Poly(A) hydrolase of chick-embryo fibroblasts.

1. Homogenates of cultured chick embryo fibroblasts have been quantitatively fractionated by differential centrifugation. Using cytochrome c oxidase, succinate dehydrogenase, acid phosphatase and NADPH-cytochrome c reductase as marker enzymes, poly(A) hydrolase has been shown to be a mitochondrial enzyme. 2. To test the biosynthetic origin of mitochondrial poly(A) hydrolase and to demonstrate its cytoplasmic site of synthesis, we have treated the cells with ethidium bromide, inhibitor of mitochondrial transcription, and chloramphenicol and cycloheximide, inhibitors of mitochondrial and cytoplasmic translations respectively. The activity of poly(A) hydrolase has been compared to that of succinate dehydrogenase, an enzyme coded for by the nuclear genome and that of cytochrome c oxidase, an enzyme coded for partly by the nuclear genome and partly by the mitochondrial genome. The results obtained indicate that in chick embryo fibroblasts poly(A) hydrolase is an enzyme coded for by the nuclear genome. Further, the hydrolase is synthesized on cytoplasmic ribosomes and has a half-life much shorter than succinate dehydrogenase and cytochrome c oxidase.

Cell Division↗