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Biomedical subjects

C Di Gregorio

Publications and source records attributed to C Di Gregorio.

61 records · Page 4Linked to original sources
PubMedDate not supplied

Changes in pituitary LHRH incorporation during the rat estrous cycle, and in rats made anovulatory by various experimental procedures.

Variations in anterior pituitary incorporation of LHRH in various experimental conditions have been investigated by administering tritiated LHRH. The pretreatment of animals with unlabelled LHRH significantly decreased the isotope incorporation in the pituitary gland. On the other hand, the incorporating capacity of the glands appeared to significantly change in relation to the different phases of the estrous cycle, the higher grade of radioactivity being detectable during the diestrous and proestrous phases. However, the amount of 3H-LHRH incorporated in the pituitary gland of rats bearing different types of constant estrous-anovulatory syndrome did not present significant variations in relation to the procedures employed in sterilization. Only rats neonatally androgenized with 1250 micrograms testosterone propionate showed a marked decrease of the incorporating capacity of the pituitary. One can conclude that the variations in pituitary responsiveness previously demonstrated among rats with the same anovulatory states are independent of LHRH incorporating capacity of the pituitary.

Animals↗
PubMedDate not supplied

Epidemiology of cancer of the large bowel--the 12-year experience of a specialized registry in northern Italy.

BACKGROUND: In 1984, a specialized colorectal cancer registry was instituted in Modena; aims of the Registry were: the evaluation of incidence and mortality, the study of morphological aspects, staging, survival and familiarity of the registered patients. AIMS: Purpose of the research was to provide an updated description of the main findings (in particular, incidence, staging, morphology and survival) observed in the 12-year registration period. PATIENTS AND METHODS: Between January 1984 and December 1995, 1,899 malignancies of the large bowel in 1,831 patients were registered. Tumours were classified according to the International Classification of the Diseases for Oncology (ICDO) and staged with the TNM system. Cancer specific survival was assessed with life table analysis and Log-Rank tests. RESULTS: Crude incidence rate showed minor fluctuations between 1984 and 1989, but tended to rise in the following years. Tumours were mostly located distal to the splenic flexure (73.3% of the total), with a slight tendency over time to a gradual "shift" to the right colon. Staging became progressively more favourable throughout the registration; in 1984 both stages I, II and stage IV + unstaged lesions represented 40% of the total, but in 1995 the former rose to 50% whereas the latter fell to 21.6% (p < 0.001). This move to earlier stages resulted in an improved survival of patients registered in 1990-91 versus 1984-85 (Log-Rank 14.3 p < 0.002). Factors associated with a poor survival were the advanced age of patients at diagnosis (> 74) and clinical stage.

Aged↗
PubMedDate not supplied

[Observation of a case of Wells syndrome: ultrastructural study].

A new case of Wells' syndrome is reported. Histologically the infiltrate of eosinophils extended to the deep dermis and the subcutaneous fat. The characteristic flame figures are seen in the dermis. Ultrastructurally eosinophils were numerous half of then degranulated. No injury to the vessel walls and collagen bundles were observed. The Authors emphasized that Wells' syndrome is a distinctive entity clinical, on likely autoimmune basis, with multiple triggering factors and peculiar histopathologic but not diagnostic picture.

Adult↗
PubMedDate not supplied

Perineural infiltration by cutaneous squamous cell carcinomas of the head and neck.

In this paper six cases of cutaneous squamous cell carcinoma of the head and neck region with histologically-documented perineural tumoral infiltration are presented. Most patients showed recurrent disease during follow-up and have been treated with surgery and radiotherapy with or without systemic chemotherapy. The prognostic implications of perineural neoplastic infiltration as well as of therapeutic options are discussed.

Aged↗
PubMedDate not supplied

Mental nerve invasion by basal cell carcinoma of the chin: a case report.

A case of perineural infiltration from recurrent cutaneous basal cell carcinoma of the chin is reported. Clinical presentation, surgical treatment, and pathological evidence are discussed. This report stresses the importance of a correct follow-up and an accurate clinical staging in order to identifying clinical signs highly suspicious for neoplastic perineural infiltration.

Aged↗