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C Di Gregorio

Publications and source records attributed to C Di Gregorio.

At least 55 records · Page 3Linked to original sources
PubMed1992

Lower eyelid reconstruction by multiple subcutaneous pedicle flaps: a new method.

In this paper we present an original technique for the reconstruction of the full thickness of the lower eyelid after excision of neoplasms. The method is based on the mobilisation of multiple pedicle subcutaneous flaps outlined in the same eyelid and supported by a chondro-mucosal graft. This technique is used for central and off-central losses which involve the outer rim or up to 75% of the width of the whole eyelid. This method is an alternative to the Hughes (1945), Mustardé (1981), Tenzel and Stewart (1978) and McGregor (1973) techniques which we have previously used for this type of reconstruction. The follow-up is satisfactory in terms of the oncological, functional and aesthetic aspects, which represent an inseparable triad in reconstructive eyelid surgery.

Cartilage↗
PubMed1992

Right colon adenocarcinoma presenting as Bacteroides fragilis liver abscesses.

Pyogenic abscesses of the liver occur in association with a variety of diseases. Sometimes they are caused by anaerobic infections of liver metastases. Uncommonly, however, multiple hepatic abscesses caused by anaerobic bacteria are the presenting signs of unsuspected colonic cancer in the absence of liver metastases. We report a 60-year-old man who presented with febrile cholestatic liver disease initially thought to be metastases. Repeated ultrasound-directed liver biopsies yielded a diagnosis of multiple abscesses. Bacteroides fragilis was grown from the liver specimen and the patient responded well to metronidazole treatment. Two months later, however, overt symptoms of large bowel disease led to the diagnosis of colonic adenocarcinoma. After a 6-month postoperative follow-up, the patient is free of liver metastases. Anaerobic liver abscesses should always alert the clinician to possible silent colonic cancer.

Adenocarcinoma↗
PubMed1992

Acanthamoeba meningoencephalitis in a patient with acquired immunodeficiency syndrome.

Several cases of Acanthamoeba encephalitis (ie, granulomatous amebic encephalitis) have been reported in patients with acquired immunodeficiency syndrome from the United States. To our knowledge, none so far has been reported from Europe, and this is the first case of amebic meningoencephalitis due to Acanthamoeba in a patient with acquired immunodeficiency syndrome from Italy. The patient was a 24-year-old, human immunodeficiency virus-positive heterosexual man with a 6-year history of intravenous drug use. He was admitted to the hospital because of severe headache, confusion, nuchal rigidity, jaundice, and ascites. He died 5 days later. At autopsy, the brain showed extensive hemorrhagic necrosis with numerous trophic and cyst forms of Acanthamoeba. The amebas were identified as Acanthamoeba divionensis by the indirect immunofluorescence test.

AIDS-Related Opportunistic Infections↗
PubMed1991

Nucleolar organizer regions in malignant melanoma and melanocytic nevi. Comparison of two counting methods.

Using a silver staining technique, we studied nucleolar organizer regions (AgNOR) in paraffin sections of junctional nevi, compound nevi, intradermal nevi, blue nevi, dysplastic nevi, Spitz nevi, lentigo maligna, malignant melanomas in nevus, superficial spreading melanomas, and nodular melanomas. Two methods of counting black dots within nuclei were employed. One method was to count the discrete black dots within the nuclei, including the tiny black dots seen within the nucleolus; the second method did not take into account the subsidiary cluster of tiny black dots seen within the nucleolus, instead treating these dots as a single structure. Whichever method we used, a significant difference was found between the pooled mean AgNOR numbers for benign and malignant lesions. We found an overlap, however, between benign, in particular Spitz and dysplastic nevi, and malignant lesions when considering individual counts of AgNOR using both methods. We conclude that studying AgNOR does not seem to be a useful technique to differentiate Spitz and dysplastic nevi from malignant melanomas.

Diagnosis, Differential↗
PubMed1991

Reliability of 3H-thymidine labeling index: cell proliferation of colorectal carcinoma in three different centers.

Although the 3H-thymidine labeling index (TLI) has been used extensively as a biologic marker of increased susceptibility to neoplasms or as a prognostic indicator of the clinical outcome in cancer patients, there is still some concern regarding its accuracy and reliability as a marker of cell replication. A study on the prognostic value of TLI in colorectal cancer gave us the ability to evaluate how such a measurement may vary in different laboratories. A total of 150 malignant tumors of the large bowel were studied in the period from 1988 to 1989. Microautoradiography was carried out in tumor fragments taken at surgery. There were only slight differences among the three centers involved in the investigation, mainly as regards the culture medium, exposure time, and the addition of O2 + CO2 during the incubation. No significant difference was observed among TLI values recorded in the three centers (18.3 +/- 0.9; 17.4 +/- 0.9; 15.7 +/- 1.0 mean +/- SE), and the ranges of values were almost identical. Similarly, the numbers of total and of labeled cells counted for each patient were comparable among the three centers. The frequency distribution of TLI showed a peak value between 10 and 19.9% in all three centers. Moreover, more than 80% of the observed values were within the range of 10 to 29.9%. In addition, the neoplastic areas with the highest proliferative activity ("high" TLI) showed a frequency distribution once again rather similar among the three centers.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1991

Large intramural cyst of the uterus. Report of a case.

A case of a rare lesion, i.e., congenital intramural cyst of the uterus, is reported. The diagnosis of paramesonephric cyst was suggested on the basis of histopathologic, histochemical and immunohistochemical findings. The literature is reviewed and the differential diagnosis of this lesion is discussed.

Adult↗
PubMed1990

Familial occurrence of gastric cancer in the 2-year experience of a population-based registry.

The authors studied the familial occurrence of tumors in 154 individuals with gastric cancer by reviewing the clinical data and the genealogical tree of all patients registered in 1986 through 1987 in the Local Health Care District of Modena, Italy, for cancer of the stomach. Crude and age-adjusted (world population) incidence rates of gastric cancer were 34.0 and 21.4 new cases/100,000/year, respectively, in men, and 24.5 and 10.9 in women, respectively. Among first-degree relatives of the registered patients there were 30 cases of gastric carcinoma versus 15 cases in a control group matched for age and sex (Mantel-Haenszel odds ratio [M-H OR] 3.14, P less than 0.01). This excess of gastric neoplasms was observed in siblings (17 versus 7, M-H OR 4.33, P less than 0.02) but not in parents (13 versus 8, not significant). Besides gastric cancer, there was no significant excess of other type of tumors in case families. The familial occurrence of gastric cancer tended to be more frequent in patients with "diffuse" carcinoma (52%) than in subjects with "intestinal" cancer (33%), although the difference was not statistically significant. In conclusion, the current investigation suggests that a "family history" for gastric neoplasms is usually observed in approximately 10% to 15% of the registered cases. As already described for other common malignancies, therefore, the familial occurrence of gastric carcinoma suggests the existence of a genetic susceptibility to cancer of the stomach, at least in a fraction of these patients.

Adult↗
PubMed1990

Granulomatous hepatitis in a patient receiving methimazole.

A very rare case of granulomatous hepatitis in a 56-year old woman with hyperthyroidism, under long-term treatment with methimazole, is reported. Liver biopsy showed multiple non caseous granulomas in the portal triads, consisted of epithelioid and multinucleated cells, lymphocytes and isolated eosinophils. The presence of eosinophils in granulomas, could indicate an iatrogenic aethiology.

Chemical and Drug Induced Liver Injury↗
PubMed1989

Multinucleated giant cells in AIDS encephalopathy: an immunohistochemical study.

We report the neuropathological findings of 5 post-mortem cases of AIDS. The most common causes of the death were multiple opportunistic infections associated with cutaneous and/or visceral Kaposi sarcoma in two cases. Cerebral edema, demyelination and spongiosis of the white matter were present but the most remarkable finding was the presence of multinucleated giant cell (MGC) within and nearby microglial nodules. On immunohistochemical investigation MGC and microglial cells exhibit positive stain only for RCA I and Ferritin, while immunohistochemical markers for astrocytes, neurons, macrophages, histiocytes, lymphocytes and endothelial cells were negative. No microrganism, nor viral inclusions were detected. These results support the hypothesis that MGC may be derived from microglial cells.

Acquired Immunodeficiency Syndrome↗
PubMed1989

Melanosis (pigmented melanocytosis) of the prostate gland.

A case of stromal melanosis of the prostate gland is reported. Ultrastructurally, dendritic processes and melanosomes, but no basal lamina were observed in melanin-containing cells. In similar cases, characterized by the diffuse distribution of stromal pigmented melanocytes, the term 'pigmented melanocytosis' rather than 'blue nevus' appears more appropriate.

Aged↗
PubMed1984

Melanotic schwannoma: a case report.

A case of melanotic schwannoma of the sacral region, studied with electron microscopy and immunohistochemistry, is reported. Melanosomes in all stages of formation were ultrastructurally demonstrable in neoplastic cells, which showed prominent basal lamina and interdigitating cytoplasmic processes. These findings support the Schwann cell origin of the tumor and indicate that Schwann cells are capable of melanin production. The immunohistologic examination showed the absence of neoplastic cells for all antigens tested (S-100 protein, glial fibrillary acidic protein, lysozyme, alpha 1-antitrypsin, alpha 1-antichimotrypsin, keratin). Apart from questioning the nature of the tumor, S-100 protein absence could raise doubts on its benign course. In the reported case, no local recurrence or distant metastases have been recorded 2 years after surgery.

Aged↗
PubMed1983

Melanosis of the larynx: a case report.

A case of diffuse melanosis, associated with an epidermoid carcinoma of the larynx, is reported. The case appears to be unique, the pigmentation being detectable at the gross examination.

Aged↗