[Androgens, corticosteroids and erythropoiesis].
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Biomedical subjects
Publications and source records attributed to C Delboy.
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This paper is relating the study of 164 patients with primary and proved bronchial carcinoma. A thrombocytosis superior to 400,000/mm3 was observed in 36.6 p. cent of cases. But no statistic relation was found between the histological type of tumor, a biological inflammatory state, the existence of metastasis and thrombocytosis. However thrombocytosis was more frequently observed among anaemic and hyposideremic patients. No significantly changes of paO2 and paCO2 were noted in patients with thrombocytosis. The systematic platelet count could be of an interest in the interpretation of some thoracic radiography.
During a period of five years, fifteen thousand platelet counts has been systematically realised at the Hôtel-Dieu Hospital in Marseilles. A thrombocytosis superior to 400 000/mm3 has been observed in 1,2% of cases, in such various etiological cases as mainly cancer (30%), infectious diseases (28%) and post-hemorragic anaemias (11%).
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The authors found a significant statistical correlation (linear and Spearman) between erythrocyte sedimentation rate (ESR), plasma fibrinogen level, alpha-2-globulins level, platelets count, anemia and age, in 1 000 patients admitted to the Hôtel-Dieu of Marseille. The high degree of partial correlations obtained, confirmed that a direct and independent relationship exists between ESR-fibrinogen, ESR - alpha-2-globulin, fibrinogen - alpha-2-globulin. Determinations of plasma fibrinogen and alpha-2-globulin levels are they still useful in the survey of inflammatory diseases when ESR can be easily determined?
Distribution and correlations of serum uric-acid, cholesterol, triglycerides and lipoproteins were sought in this paper. Blood triglycerides and blood cholesterol in males were found significantly higher in patients with hyperuricaemia than in normo-uricaemic subjects. This elevation was reflected in the electrophoresis by a significant elevation of the bêta and pre-bêta lipoproteins correlated with hyperuricaemia. Partial correlations between age and serum uric-acid have been also demonstrated.
The frequency and nature of abnormalities of serum lipids have been studied in 1 511 patients in correlation with the localizations of atherosclerosis. The mean cholesterol concentration was significantly increased in coronary heart disease and mean triglyceride concentration was significantly increased in peripheral vascular disease. Mean values of R1 and B3 were higher in coronary heart disease, lower in cerebrovascular disease than in healthy subjects.
Changes in blood-level of cadmium, zinc, pseudocholinesterase and aldolase were studied in 44 normal subjects, 40 hypertensive patients and 40 alcoholic ones. The highest serum concentration of cadmium and pseudocholinesterase, the lowest serum and blood concentrations of zinc, the lowest serum concentrations of aldolase were found in the two groups of patients, with still lower levels in alcoholic patients than in hypertensive ones. There was a negative correlation between zinc and cadmium levels in the three groups of subjects. There was a high correlation between systolic and diastolic blood pressure value and cadmium, and negative correlation between blood pressure and zinc blood and serum levels.
The authors found a significant statistical association between thrombocytosis and anaemia in 600 patients admitted to Hotel-Dieu of Marseille: p < 10(-3) with Chi 2 test and p < 5.10(-4) with Mann-Whitney test. There is also a significant correlation (linear and non-parametric Spearmann): r = -0,212; p < 10(-3); and a partial correlation between platelets count and weight of haemoglobin, which is independant of sedimentation rate.
The authors have determined systolic time intervals with carotid arterial Doppler system in a group of 113 healthy subjects. These systolic time intervals, were independent of age but strongly influenced by heart rate, and highly significant correlated with phonocardiographic and carotid arterial pulse tracings, according to the method described by Weissler. However Doppler index, no significantly correlated with heart rate, seems to us a better assessment of left ventricular performance than Weissler index. New reports on the hemodynamic determinants in healthy subjects and in patient with chronic heart failure are necessary.