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Biomedical subjects

C D Frith

Publications and source records attributed to C D Frith.

At least 271 records · Page 15Linked to original sources
PubMed1977

Two kinds of cognitive deficit associated with chronic schizophrenia.

The performance of 21 chronic schizophrenic patients was investigated on two tests of feature selection. It was found that patients with negative symptoms (muteness, withdrawal, etc.) were characterized by an extreme lack of persistence, but selected usual features; whereas patients with positive symptoms (hallucinations, delusions, etc.) had a normal degree of persistence, but selected unusual features.

Aged↗
PubMed1976

Cerebral ventricular size and cognitive impairment in chronic schizophrenia.

By comparison with age-matched controls in employment, 17 institutionalised schizophrenic patients were shown by computerised axial tomography of the brain to have increased cerebral ventricular size. Within the group of schizophrenic patients increased ventricular size was highly significantly related to indices of cognitive impairment.

Adult↗
PubMed1976

Double-blind clinical trial of 5-hydroxytryptophan in a case of Lesch-Nyhan syndrome.

5-Hydroxytryptophan (5-HTP) treatment of a single case of Lesch-Nyhan syndrome showing compulsive self-mutilation, athetoid movements, and characteristic clinical biochemical picture was studied on a double-blind basis. 5-HTP or placebo was administered for seven fortnightly treatment blocks. 5-HTP produced a significant reduction of athetoid movement and a sedative effect but did not improve the patient's mood or reduce self-mutilation.

5-Hydroxytryptophan↗