Search PubMed⌕ Search

Biomedical subjects

C Cruz

Publications and source records attributed to C Cruz.

At least 199 records · Page 11Linked to original sources
PubMed1980

Sonographic features of ATN and of acute rejection in renal allografts.

The sonographic changes occurring during post transplant acute tubular necrosis and rejection are discussed. Seven patients with proven ATN are shown to maintain normal sonographic features and exhibit normal hypertrophy. In contrast during acute rejection the findings in 21 patients included in order of frequency the following 1) sudden increase in renal volume, 2) prominent medullary pyramids, 3) abnormal echogenicity, 4) decreased amplitude of the central sinus echoes, 5) increased cortical thickness, 6) crescent shaped fluid collections and 7) indistinct corticomedullary boundary.

Acute Kidney Injury↗
PubMed1979

Nuclear bodies in nerve cells of two patients with normal-pressure hydrocephalus.

Biopsy specimen fragments from two patients with normal-pressure hydrocephalus were studied using ultrastructural methods. Simple nuclear bodies were found in all layers of the cortex and white matter, whereas complex ones were only seen in the fifth and sixth layers and in the underlying white matter. There may be a relationship of these nuclear bodies, either to the neuroglial proliferation observed in both patients or to the existence of a viral infection of the CNS.

Adult↗
PubMed1979

Neurofibrillary changes in the cerebral cortex of a patient with subacute sclerosing panencephalitis (SSPE).

Biopsy fragments from the frontal cortex of one patient with SSPE were studied with ultrastructural methods. Special attention was given to the presence of neurofibrillary tangles observed in all cortical layers. These tangles were composed either of filaments with a diameter of 10 -- 12 nm or of paired helical filaments 22 -- 24 nm at their widest and periodically reduced to 10 nm about every 80 nm. These tangles were observed in all cortical layers, while those formed by single filaments were only visualized in layer 3. The simultaneous appearance of both types of tangles in the same patient suggests that they may be chemically related, which is in keeping with recent chemical data concerning the nature of the neurofilament protein subunit.

Adolescent↗
PubMed1978

Dialysis elbow.

Explore the source record for details and available documents.

Bursitis↗
PubMed1978

Multivesicular bodies in cortical dendrites of two patients with Alzheimer's disease.

Biopsy fragments from the frontal cortex of 2 patients with Alzheimer's disease were studied with ultrastructural and cytochemical methods. A great number of light and dark, acid phosphatase positive, multivesicular bodies were observed in dendrites and their spines, in all cortical layers, being more abundant in layers 3 and 4. A close topographic relationship between these organelles and post-synaptic membranes was found. It is postulated that these findings might be related to the neurite formation of the senile plaques and to the synaptic involvement in Alzheimer's disease.

Alzheimer Disease↗
PubMed1977

Tetanus antibody production in serum and cerebrospinal fluid in the rabbit and correlated histopathological features of the central nervous system.

The histopathological features in the central nervous system (CNS) developing during the active phase of tetanus antibody formation in the cerebrospinal fluid (CSF) as induced in 15 rabbits were studied. The measurement of antibody titres in serum and CSF by electroimmunodiffusion and histological examination were done sequentially at the 1st, 3rd, 5th, 7th and 9th days after cisternal secondary inoculation with fluid tetanus toxoid. Tetanus antibodies appeared in serum after the 1st and in CSF after the 5th day. Decreasing values of CSF total protein were found. The meaning of an elevated Q ratio as observed in this situation of strong antibody formation in the CSF was enhanced. The histopathological features in the central nervous system consisted of perivascular inflammatory infiltration, at first polymorphic and then composed almost exclusively of mononuclear cells with a predominantly leptomeningeal and subpial localization, which might represent the origin of CSF tetanus antibodies. The localization was related to the contact zone between the antigen- and antibody-containing compartments, respectively the subarachnoid space and vascularized structures of the brain and spinal cord. Four control rabbits presented neither tetanus antibodies in the CSF nor perivascular inflammatory infiltration in the CNS. Similarity between the present experimental results and the immunopathological features of the primary demyelinating diseases provides some useful information about the immunological inflammatory events in these diseases.

Animals↗
PubMedDate not supplied

Dopamine D4 receptor (DRD4) gene polymorphism in the first psychotic episode.

BACKGROUND: Dopamine D4 receptor (DRD4) has shown some interesting properties at genetic and possibly functional levels. It has been suggested that some molecular variants of the DRD4 gene (e.g., four and seven alleles) could be implicated in the pathogenesis of psychotic disorders. Additionally, the VNTR polymorphism could be implicated in part of the response to treatment with neuroleptics. This study tested the possible association between the 48-bp tandem repeats in exon 3 of the DRD4 gene and patients experiencing their first psychotic episode. METHODS: Patients with a first psychotic episode (FPE, n = 37) were diagnosed and compared with a matched control group (n = 37). The FPE group was subdivided into two categories: those with nonaffective and those with affective psychoses. The variable number of tandem repeats (VNTR) region of the DRD4 gene was amplified by PCR procedures. Chi-square statistics and appropriate corrections and adjustments were used for data analysis. CONCLUSIONS: A significantly lower frequency of the four repeat (4-R) carriers in the FPE group was observed. This association was sustained mainly by the affective psychotic group (chi2 = 9.99 df = 2, p = 0.0073). Although these results require testing with stringent methods, it is suggested that the DRD4-4R allele may confer some protection against psychosis, mainly of the affective subtype.

Humans↗