Gentamicin treatment of staphylococcal infections.
Explore the source record for details and available documents.
Adult↗
Biomedical subjects
C Cox
Publications and source records attributed to C Cox.
The nature and extent of speed use in North America.
Explore the source record for details and available documents.
Female↗
Treatment of ventricular arrhythmia by permanent atrial pacemaker and cardiac sympathectomy.
Explore the source record for details and available documents.
Anti-Arrhythmia Agents↗
Auer rods in the acute myeloid leukemias: frequency and methods of demonstration.
One hundred and twenty-five cases of acute myeloid leukemia (AML) were reviewed for the presence of Auer rods by two peroxidase methods. The percentage of Auer rods recognized by Wright-Giemsa (WG) staining was 20.8% but three times higher by peroxidase staining techniques using either benzidine base as a substrate (PO method) or 3,3'-diaminobenzidine as a substrate (DAB method). Both PO and DAB methods were equally sensitive in identifying Auer rods, the higher percentage being in FAB types M2 and M4 and lower in M1, M3, and M5B, with none in M5A. Cell counts of at least 100 cells were as accurate as counting cells up to a total of 1000 consecutive blasts.
Bone Marrow↗
A comparison of chi-square partitioning and two logit analyses of ordinal pain data from a pharmaceutical study.
We study three approaches for the analysis of ordinal pain data. The first is essentially non-parametric, based on partitioning the goodness-of-fit statistic for testing the homogeneity model. The other two involve the modelling of quite different logit functions of the multinomial probabilities. We discuss and compare the characteristics of these three approaches using actual data from an analgesic trial.
Analgesics↗
The training of surgeons in America.
Explore the source record for details and available documents.
Breast Neoplasms↗
Neurobehavioral toxicity of methanol reflected by operant running.
Eleven Long-Evans male rats were trained to respond for food delivery by running in wheels under a Fixed Ratio = FR 20 schedule of reinforcement. Each 360 degrees rotation counted as a single response. Three food pellets were delivered for each reinforcement. The wheels, which provided transverse rods to be gripped by the rats, were specifically designed to reflect motor deficits produced by neurotoxicants. Each animal received two replicates of three different doses of methanol (50% in water): 1.0, 2.0, and 3.0 g/kg by gavage. The sequence for each animal was determined by a counterbalanced design. Gavage was followed by admitting the animal to the running wheel compartment 10 min later. Running wheel sessions lasted for 1 hour daily and were conducted 6 days/week. Statistical analyses showed insignificant differences between water and no-treatment control days, indicating no effect of the gavage procedure. However, a dose-effect relationship between methanol dose and responses per session proved statistically significant and linear (p < 0.0001) down to a dose equivalent to 10% of the LD50. In addition, detailed analyses of intervals between successive rotations (IRTs) indicated a displacement of the distribution toward longer intervals (decreased velocities) with increasing dose. The absence of a corresponding rise in the incidence of long pauses suggested that impaired coordination, reduced endurance, or their combination, rather than nonspecific variables, accounted for these results.
Animals↗
Ketorolac or fentanyl to supplement local anesthesia?
STUDY OBJECTIVE: To evaluate the usefulness of ketorolac in the treatment of intraoperative pain refractory to the administration of local anesthetic alone. DESIGN: Intraoperative acute-pain treatment model consisting of awake, nonsedated patients who randomly received either an opioid or a study drug in a double-blind fashion. SETTING: University medical center. PATIENTS: Eighty patients who underwent breast biopsy, lumpectomy, or central venous catheter placement. INTERVENTIONS: Patients received either ketorolac 1 mg/kg intravenously (IV) up to a total dose of 60 mg or fentanyl 3 micrograms/kg IV up to a total dose of 250 micrograms to supplement the local anesthetic. MEASUREMENTS AND MAIN RESULTS: Verbal pain evaluation and the visual analog scale (VAS) were used for perioperative measurement of pain. Heart rate (HR), blood pressure, and respiratory rate (RR) were recorded before and after analgesic drug injections at 10-minute intervals, both intraoperatively and while the patient was in the postanesthesia care unit (PACU). Speed of recovery was quantified by p-deletion and digit substitution tests on admission to the PACU and at 30-minute intervals until discharge. The frequency of nausea, vomiting, and pruritus were recorded. There were no differences between the groups in perioperative verbal pain evaluation, VAS scores, HR, systolic blood pressure, diastolic blood pressure, or RR. Patients who received ketorolac exhibited a significantly lower frequency of intraoperative and postoperative medication administration intraoperatively, than those who received fentanyl. No additional pain medication was required by patients in the PACU in either group. CONCLUSIONS: Ketorolac is a useful alternative to fentanyl for the treatment of intraoperative pain refractory to the administration of local anesthetic alone during monitored anesthesia care. A decided advantage of ketorolac over fentanyl is the absence of nausea and vomiting in the intraoperative and postoperative periods.
Adult↗
Personality traits of women with a history of childhood sexual abuse.
This study examined relationships between specific dimensions of childhood sexual abuse and personality traits in adulthood. Study participants were 74 hospitalized female psychiatric patients with a self-reported history of childhood sexual abuse. Characteristics of childhood sexual abuse were obtained from a structured life-events interview. Personality was measured with the NEO-Five-Factor Inventory (NEO-FFI), which yields scores on neuroticism, extraversion, openness to experience, agreeableness, and conscientiousness. We hypothesized that parental abuse, intercourse, and the combination of these two childhood sexual abuse characteristics would be associated with personality traits. Supporting this hypothesis, women who were abused by a parent had lower scores on openness to experience than women who were abused by someone else. Patients whose abuse history included both parental abuse and intercourse had very low extraversion scores. Our findings suggest that there are associations between personality traits and childhood sexual abuse characteristics in psychiatric patients. Specifically, women who experienced intercourse by a parent may be more introverted and less open to experience than women whose sexual abuse history does not include parental incest.
Adolescent↗
Analysis of message expression in single neurons of Alzheimer's disease brain.
Because many cell types and disease states exist in the sample of cells in even a very small region of Alzheimer's disease (AD) brain tissue, optimal understanding of disease mechanisms requires study at the level of the single cell. Our Golgi studies of single neurons in the AD brain have revealed reduced dendritic extent in many, but not all, brain regions. This reduced dendritic extent is interpreted as reduced capacity of neurons in AD to proliferate new dendritic material. Studies of message expression in single neurons reveal that neurons containing neurofibrillary tangles (NFTs) show reduced expression of messages for proteins related to growth of neuronal processes and to synapses. Neighboring neurons free of NFTs express these messages at levels approximating the levels expressed by single neurons from control brain. This reduction of expression of messages related to growth of neuronal processes and to synapses is selective, because expression of message for the lysosomal enzyme, cathepsin D, is increased in neurons containing NFTs. Simultaneous analysis of the expression of multiple genes by single neurons using an aRNA technique offers powerful capacity to profile message expression as a function of disease state of single cells.
Alzheimer Disease↗
Prenatal cocaine exposure produces gender-specific motor effects in aged rats.
This investigation employed a longitudinal analysis of a complex motor skill in rats that were exposed prenatally to cocaine. Offspring were derived from four maternal treatment groups: 50 mg/kg cocaine, their pair-fed controls, 25 mg/kg cocaine, and freely fed controls. Cocaine was administered via gavage from gestation day 6-20. A maternal fostering procedure was used. Pairs of male and female littermates began training when 9, 13, or 19 months old. The behavioral procedure involved fixed-ratio (FR) lever pressing to obtain brief periods of wheel running. The oldest males from the 50 mg/kg, 25 mg/kg, and pair-fed groups performed significantly fewer wheel revolutions per opportunity than females or freely fed males. In general, animals earned fewer opportunities to run as the FR requirement was increased over sessions. However, within each age-by-gender group, subjects from the four treatment groups performed equivalent amounts of lever pressing. The specific effect on the motor aspect of the procedure may have resulted from a reduction of motor coordination, balance, or strength, or a diminished capacity of wheel running to serve as a reinforcing stimulus in a cocaine-sensitive subgroup.
Animals↗
Effects of age and gender but not prenatal cocaine on random ratio and delayed spatial alternation responding in rats.
This investigation employed a longitudinal analysis of rat operant behavior under two different schedules of reinforcement following prenatal exposure to cocaine. Offspring were derived from four maternal exposure groups: 50 mg/kg cocaine, their pair-fed controls, 25 mg/kg cocaine, and freely fed controls. Cocaine was administered via gavage from gestation day 6-20. A maternal fostering procedure was used. Pairs of male and female littermates were assigned to a 7-, 14-, or 21-month cohort and at the appropriate age were trained to respond on one lever in a two-lever operant chamber. Reinforcement was delivered with a series of random ratio (RR) schedules where the RR value was increased across sessions. After RR training, animals were examined with a delayed spatial alternation (DSA) procedure in the same chambers. Male offspring responded at higher rates than females during high-probability RR schedules, whereas advancing age was associated with lower response rates during low-probability RR schedules in both males and females. Prenatal cocaine exposure exerted only limited effects on RR responding during transition and did not affect DSA behavior. The results of this longitudinal analysis suggest that prenatal cocaine does not exert global or far-reaching learning deficits in prenatally exposed rats.
Aging↗
After the drinking stops: completed suicide in individuals with remitted alcohol use disorders.
A substantial minority of suicide victims have remitted alcohol use disorders. The authors hypothesized that psychiatric disorders are likely to be present in this group to create the necessary conditions for suicide. They compared suicide victims with active alcohol use disorders and those with remitted alcohol use disorders. Using data on a community sample of suicide victims (N=141), it was determined that 39% (N=55) had a history of alcohol misuse. These subjects were categorized by alcohol use disorder status (remitted versus active) and by age (<50, > or =50), creating four cells: younger remitted (N=8), older remitted (N=9), younger active (N=22), and older active (N=16) alcohol misusers. Results comparing proportions of DSM-III-R Axis I disorders in the four groups indicated that suicide victims with remitted alcohol use disorders were predominantly younger victims with psychotic disorders or older victims with major depression. These findings have implications for identifying those at risk for suicide even after the cessation of alcohol misuse. Case examples of suicide victims with remitted alcohol use disorders-a younger woman victim with a psychotic disorder and an older man with major depression-are presented.
Adult↗
Medical education, women's status, and medical issues' effect on women's health in the Caribbean.
At an international conference in 1992 on women and health, an attempt was made to redefine health concerns for women of the English-speaking Caribbean in the 1990s. Medical practices in developing countries change as advances are made in public health; clinical issues on the islands now resemble those in the United States (e.g. hypertension, cancer, sexually transmitted diseases, domestic violence, and abortion). In the Caribbean, however, these problems exist in a unique socioeconomic context, and women's health there suffers indirectly because of cultural mores. Gender bias in medical education and practice influences treatment of women and obstructs their advancement to policy-making levels in the design and delivery of programs that bear on maternal and child health, among others. The effect of local cultural beliefs and practices on women's health must be considered when setting goals and direction for health policy if aid or educational programs are to be effective.
Abortion, Induced↗
Cognitive deficits associated with blood lead concentrations <10 microg/dL in US children and adolescents.
OBJECTIVE: Lead is a confirmed neurotoxicant, but the lowest blood lead concentration associated with deficits in cognitive functioning and academic achievement is poorly defined. The purpose of the present study was to examine the relationship of relatively low blood lead concentrations-especially concentrations <10 micrograms per deciliter (microg/dL)--with performance on tests of cognitive functioning in a representative sample of US children and adolescents. METHODS: The authors used data from the Third National Health and Nutrition Examination Survey (NHANES III), conducted from 1988 to 1994, to assess the relationship between blood lead concentration and performance on tests of arithmetic skills, reading skills, nonverbal reasoning, and short-term memory among 4,853 children ages 6-16 years. RESULTS: The geometric mean blood lead concentration for children n the study sample was 1.9 microg/dL; 172 (2.1%) had blood lead concentrations > or =10 microg/dL. After adjustment for gender, race/ethnicity, poverty, region of the country, parent or caregiver's educational level, parent or caregiver's marital status parent, serum ferritin level, and serum cotinine level, the data showed an inverse relationship between blood lead concentration and scores on four measures of cognitive functioning. For every 1 microg/dL increase in blood lead concentration, there was a 0.7-point decrement in mean arithmetic scores, an approximately 1-point decrement in mean reading scores, a 0.1-point decrement in mean scores on a measure of nonverbal reasoning, and a 0.5-point decrement in mean scores on a measure of short-term memory. An inverse relationship between blood lead concentration and arithmetic and reading scores was observed for children with blood lead concentrations lower than 5.0 microg/dL. CONCLUSION: Deficits in cognitive and academic skills associated with lead exposure occur at blood lead concentrations lower than 5 microg/dL.
Adolescent↗
Interictal aggression in epilepsy: the Buss-Durkee Hostility Inventory.
Adult patients with left, right, or bilateral temporal lobe epilepsy or absence epilepsy, and normal controls completed the Buss-Durkee Hostility Inventory (BDHI), a standardized questionnaire of aggressive tendencies. Patients with left temporal lobe seizure foci scores higher on the Suspicion scale than did other patients or controls (p < 0.05). Factor analysis scale scores identified three factors: hostile feelings, covert aggression, and overt aggression. The groups differed on their pattern of factor scores (p < 0.01): patients with left temporal lobe epilepsy scored higher than other groups on hostile feelings, normal controls scored higher on Covert aggression, and bitemporal patients scores higher on Overt aggression. Patients with absence seizures did not differ from controls. Lateralization of the seizure focus in patients with temporal lobe epilepsy may alter expression of aggressive behavior.
Adult↗
Development of the female great call in Hylobates gabriellae: A case study.
Although the structure of adult gibbon duet singing has been characterised in most species, little is known about the ontogeny of gibbon song. The present study describes the developmental trajectory of the female great call in a captive infant Hylobates gabriellae female, on the basis of periodic tape recordings made while she participated in the duetting of her parents. The major part of great call development is completed between 5 and 32 months of age, and a differential time course is apparent for different portions of the female great call, raising the question of the role of the protracted period of vocal development in this species.
Animals↗
Psychotherapy and sociology: flirtation, marriage or divorce?
Psychotherapy and sociology are themselves products of mixed marriages; each experiences problems of identity and their children face problems of legitimacy. This paper considers the relevance of some sociological perspectives to the psychotherapeutic process, using the following analogies; (1) Flirtation: Why the attraction? 'going steady' or 'femme fatale'? (2) Marriage: Mutual enrichment, cross-fertilisation and new life? Examples of shared perspectives in the work of E. Becker, Erikson, Goffman etc. Influence of psychosocial contexts on psychotherapeutic processes. (3) Divorce: Too little shared life or too much destructive criticism? If the world within man and the world between men are interrelated, psychotherapy and sociology--although at times uneasy bedfellows--have much to give each other.
Psychotherapy↗