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Biomedical subjects

C Cotrutz

Publications and source records attributed to C Cotrutz.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Electron microscopy study regarding the etiology and the pathogenesis of acne vulgaris].

The etiology and the pathogenesis of acne vulgaris are not complete cleared up yet. This work presents the results of the electronomicroscopic examinations effected on lesions of acne vulgaris biopsied from 5 patients with different clinical forms of disease (including acne fulminans). In this study we had in view the investigation and description of the ultrastructural modifications that followed the intervention of the 4 factors incriminated in the etiology and pathogenesis of acne: sebaceous hypersecretion, hyperkeratosis pilosebaceous infundibulum, bacterial colonisation, perifollicular inflammation. The ultrastructural aspects that we had in view underline the role of the 4 etiology and pathogenesis factors of acne vulgaris, confirming the data related by the specialised literature.

Acne Vulgaris↗
PubMedDate not supplied

[Electron microscopy in oral squamous cell carcinoma of elderly patients].

OBJECTIVES: Squamous cell carcinoma is the most frequent tumor occurring in the oral cavity. The aim of the study is to point out the fine-structural characteristics of the tumor cells and of the adjacent stromal cells, trying to establish a correlation between these characteristics and the biological behavior of the tumor. MATERIAL AND METHODS: We performed an electron microscopic investigation for tree elderly patients diagnosed with oral squamous cell carcinoma. RESULTS: The tumoral cells presented nuclear abnormalities and the reduction of the intercellular cohesion, through an increase in the intercellular spaces, and desmosomal modifications. Through the abundance and the variety of the cellular types, the stromal component represented a positive response from the host. CONCLUSIONS: In the diagnosis of the oral carcinoma, the electron microscopic exam supplements the light microscopic investigation, revealing important morphologic elements at a subcellular level (regarding the nucleus, cellular organelles, and junctions).

Aged↗
PubMedDate not supplied

Ultrastructural differentiation of the glomerular mesangium from the human metanephros.

In section of metanephros tissue obtained from 32 human embryos and fetuses, 8 to 24 weeks old, the mesangial cells differentiate beginning with the 12th week. Some of the cells from the central mass of the metanephros blastema showed endocytosis phenomena characteristic for the adult mesangial cells. In the 13th week the three cellular types from the renal corpuscle individualize, and from the 14th to the 16th week they acquired the adult morphological aspect.

Cell Differentiation↗
PubMedDate not supplied

[Ultrastructural aspects in the development of the human heart. II. The endocrine cells of the embryonic heart].

Electronmicroscopic studies performed on atrial and ventricular tissue fragments from 9 human embryos, 8 to 15 weeks old, showed that in certain myocardiocytes, especially in the atrial ones, from the 10 weeks old embryos, there appear granules of secretion, very similar in morphology with those from adults, which had been demonstrated to contain the atrial natriuretic factor. The precocious appearance of this peptide represents a functional adaptation by which the embryo attempts at counterbalancing the actions of renin and angiotensin from the maternal circulation.

Atrial Natriuretic Factor↗
PubMedDate not supplied

[Ultrastructural aspects in the development of the human heart. I. The cytoskeleton and motility of human embryonic myocardiocytes].

Electron microscopic investigations performed on heart tissue fragments from 12 human embryos. 8 to 15 weeks of age, showed that at the age of 8 weeks the myocardiocytes are poorly differentiated cells: they contain microfilaments of actin and myosin inserted on the cytoplasmic aspect of plasmalemma, a smooth endoplasmic reticulin and mitochondria, accounting for the early contraction. Gap junctions appear among myocardiocytes, confirming the myogenic theory of heart contractions. Within 10 to 15 weeks, actin and myosin myofilaments organize in sarcomeres. Eberth disks appear and numerous mitoses are to be seen.

Cell Movement↗
PubMedDate not supplied

Amphicrine cells in the peritumoral gastric mucosa.

Electron microscopic researches pointed out the existence of amphicrine cells in the peritumoral mucosa on specimens of surgically resected gastric cancer. According to the ultrastructural features two cell subtypes were distinguished: mucoenterochromaffine (EC1, EC2) and empty clear mucoforming cells, corresponding to the mucoargentaffine and mucoargyrophobic types, respectively as the literature showed. Our results showed the amphicrine cells may be interpreted as transformed pathological endocrine cells under gastric cancer conditions.

Adenocarcinoma↗