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Biomedical subjects

C Cotrutz

Publications and source records attributed to C Cotrutz.

At least 19 recordsLinked to original sources
PubMed1998

Development in a Windows environment of a radiation treatment planning system for personal computers.

A new personal computer (PC) radiotherapy treatment planning system (RTPS) is presented. The PC-based RTPS is designed to run in the Microsoft Windows 3.11 environment (and later versions), for computers equipped with 486 or Pentium processors. The algorithm used by the new PC-based program for dose calculation belongs to the 'radiological pathlength' category and it was previously implemented on VAX 711 computers at Memorial Sloan-Kettering Cancer Center (MSKCC) in New York, NY, within EXTREP-III RTPS. The EXTREP-III program is a two-dimensional RTPS (with restricted three-dimensional capabilities), developed and used in clinical practice at MSKCC during the 1980s. The PC-based program is implemented in the Visual Basic (version 3.0) language and supports features commonly available in most photon-mode RTPSs: dose calculation for fixed, isocentric and rotational irradiation techniques, dose corrections for both internal inhomogeneities and external inhomogeneities (boluses and compensators), association of machine-specific beams with various wedges and blocks, etc. The graphic interface of the PC-based RTPS is completely new and is designed to meet the requirements of fast and accurate planning. The user interface consists of an event-oriented button-based console which allows users to perform planning and to have isodose charts overlaid on patient computed tomography images initially loaded in the program. The PC-based RTPS tests, performed in order to assess its accuracy and speed of computation, show good results. The acceptable computation times obtained, the good accuracy in dose computation and the user-friendly interface of the program are sufficient reasons to consider the PC-based RTPS a good quality-price ratio tool for radiation treatment planning in cancer therapy.

Algorithms↗
PubMed1978

[Phlebectasia of the internal jugular vein post injury (author's transl)].

The authors present the case of a 14 year-old girl having the cervical deformity developed on the background of influenza and sore throat and was caused by an apparently minor sports injury, with vertebrocervical lesion and rupture of the inner wall of the jugular vein. The painful onset symptomatology, initially attributed to exacerbation of the anginous process and cervical adenitis, evolved towards phonation, deglutition, nervous and final respiratory disturbances. The progressive evolution and gravity of the clinical picture imposed craniocervical surgery, with exclusion of the lateral intramastoid sinus and resection of the extensive ectatic cervicoprevertebral pouch. The authors discuss the mechanism of the vascular lesion, the clinical picture, evolution, diagnosis and therapy, which totaly differed from classical descriptions of phlebectasia of the jugular vein.

Adolescent↗
PubMedDate not supplied

TLC--a rapid method for liposome characterization.

One of the most important problems for the use of liposomes as a drug delivery system is the modification of the vesicle induced by the liquid medium in which they are introduced (blood plasma for in vivo studies and the saline buffer solution for in vitro studies). Using thin-layer chromatography (TLC) we compared the behaviour of phosphatidylcholine (used for liposomes preparation) to that of the following unfilled liposomes: multilamellar liposomes (MLV); small unilamellar vesicles (SUV); and reverse phase evaporation vesicles (REV), before and after storage for 15 min in Krebs-Henseleit solution (37 degrees C, pH 7.4, aerated continuously with 95% O2 + 5% CO2). All variants contained the same amount of phosphatidylcholine. Thin-layer chromatography was performed on silica gel 60 as adsorbent. Two types of solvents were tested: one based on chloroform/alcohol (n-butanol or n-propanol or methanol)/water mixture (in different ratios) and another based on alcohol/alcohol/water mixture (n-butanol/n-propanol/water in 4/3/3 volume ratio). In all variants of chloroform containing solvents no differences were found between phosphatidylcholine and all types of liposomes. When using as solvent n-butanol/n-propanol/water significant differences were found between all types of liposomes before and after storage in Krebs-Henseleit solution. Their presence, after TLC treatment, was shown in electron microscopy studies.

Chromatography, Thin Layer↗
PubMedDate not supplied

Ultrastructural differentiation of the glomerular mesangium from the human metanephros.

In section of metanephros tissue obtained from 32 human embryos and fetuses, 8 to 24 weeks old, the mesangial cells differentiate beginning with the 12th week. Some of the cells from the central mass of the metanephros blastema showed endocytosis phenomena characteristic for the adult mesangial cells. In the 13th week the three cellular types from the renal corpuscle individualize, and from the 14th to the 16th week they acquired the adult morphological aspect.

Cell Differentiation↗