[Morphologic analysis of continuous ECG's of ventricular extrasystoles. Study of 60 subjects].
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Biomedical subjects
Publications and source records attributed to C Contini.
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Superior vena cava obstruction is described in a patient with two endocardial pacing electrodes. At necropsy a severe stenosis of the venous lumen was found at the site of intersection of the two catheters. There was no evidence of thrombus formation. Venous wall stenosis is an unusual complication of transvenous pacing and is probably favoured by the presence of two electrodes.
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A dynamic study of the hepato-biliary system was carried out by means of HIDA-99mTc and of a gamma-camera. The study was performed in basal conditions and after administration of a fatty meal. Normal subjects and patients suffering from various diseases of the biliary system were examined. The method is simple and well tolerated. Three mechanisms are invoked and discussed concerning the kinetic reactions of the gall bladder and the biliary ducts.
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The hemodynamic mechanism of the hypotensive effect of propranolol was studied by quantitative radiocardiography in 8 patients with dialysis-resistant hypertension. Propranolol treatment brought about a decrease in mean arterial pressure and peripheral vascular resistances. The cardiac index was slightly reduced only in the early stage of the treatment. No significant difference was found between patients on treatments lasting longer than 3 months and patients with dialysis-controlled hypertension. The results show that propranolol can be used safely as the sole antihypertensive agent in patients with dialysis-resistant hypertension.
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The paper summarizes the various methods of measuring the stimulation threshold in living tissues and emphasizes the usefulness of energy measures. An analog instrument for the direct measurement of the energy threshold is proposed and some experimental results obtained by its clinical application are reported.
Experience with about 1500 electrostimulated patients is reported. Rather than give statistical data we have preferred to go briefly through the problems encountered in the course of our experience and suggest possible solutions. We have emphasized the following aspects: ventricular-triggered pacemaker, stimulation threshold, haemodynamic behaviour of the paced patient, problems concerning implanted pacemakers follow-up. Our 13 years experience has opened new prospects which deserve further study, such as programmable pacemakers, optimal generator life and a few important aspects in follow-up techniques.
According to a recent national survey, 387 patients were treated by permanent pacing in 10 Italian centers, between 1961 and 1966. Of these patients 205 have died; 131 (77 males and 54 females) are still alive and no informations could be obtained for the remaining 51 (13%). The overall survival of patients treated during this period of time is therefore not less than 34% which is comparable to that of general population of the same age group. The 131 patients still alive have totaled 1,486 years of pacing and have used up to 784 pacers. Comparing the incidence of the most common causes for replacement during the periods 1961-66 and 1973-77, electrode failures dropped from 21 to 0.9%; circuitry malfunctions occurred in 10.5 and 7.8%; battery depletion rose from 36.8 to 69% of the cases. According to their clinical conditions, the 131 patients on long-term follow-up can be grouped as follows: 62% are in class 1 or 2 of NYHA; 26.7% are in class 3, and 3.8% in class 4. Moreover, 53.4% of patients are living an active life, having some sort of occupation and 29% are holding a driving license.