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Biomedical subjects

C Carbon

Publications and source records attributed to C Carbon.

At least 307 records · Page 17Linked to original sources
PubMed1977

[The nephrotoxic potential of cefalotin-aminoside antibiotic combinations (author's transl)].

The combined study of animal experimental findings and clinical trials indicates the minimal effect on renal function of a combination of Cefalotin with aminoglycosides. Nevertheless, whilst the published cases of renal insufficiency are often difficult to analyse with regard to the exclusive responsibility of antibiotic therapy, it seems that strict attention to dose and frequency of administration is essential when this combination is prescribed and that regular surveillance of renal function is necessary, above all with prolonged treatment. The renal toxicity of aminoglycosides more recent than Gentamicin has not yet been fully explored, the same applying to their use in association with Cefalotin.

Acute Kidney Injury↗
PubMed1977

Penetration of cefazolin, cephaloridine, and cefamandole into interstitial fluid in rabbits.

We compared the penetration of three cephalosporins into interstitial fluid. Interstitial fluid was obtained in rabbits from Silastic tissue cages. Cefazolin, cephaloridine, and cefamandole were administered by the intramuscular route (30 mg/kg per injection). Peak blood levels and interstitial concentrations were studied after a single injection. Interstitial levels were also compared in a three-injection study (one injection every 12 h) and in a cumulative effect study (six injections), in which the interval between injections was established for each drug on the basis of its common therapeutic use. After a single injection, cephaloridine activity was detected more rapidly and attained higher levels than the other two drugs within the first 4 h. However, 2 h after the third injection, cefazolin levels in tissue fluid were higher than with cephaloridine. Cefamandole consistently gave the lowest interstitial levels. With all three drugs, detectable concentrations were present in interstitial fluid at a time when no detectable antibiotic was found in serum. In the six-injection study, the interstitial levels obtained with cefazolin were significantly higher than those observed with the other drugs. Our data suggest that cefazolin is a drug of choice due to its high extravascular levels.

Animals↗
PubMed1976

[Study of factors favoring infection in total hip prosthesis. Twenty-five observations].

The authors report 25 cases of infection following total hip replacement and individual factors are analysed. The role of immunological abnormalities is discussed. They distinguish early infection due to the operative conditions from late infection where individual factors are the most important. A few preventive measures are proposed, they emphasise the necessity of a large scale study of factors favouring late infection.

Hip Joint↗
PubMed1976

[Clostridium perfringens infection. Problems posed excluding resuscitation].

The authors report 18 cases of Clostridium perfringens infection and discuss the main clinical and etiological aspects apart from gynecological forms and those usually requiring intensive care. Pathological foci, digestive infection and the problem of bacteremia are discussed together with appropriate treatment.

Adult↗
PubMed1974

[Septicemias].

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Anti-Bacterial Agents↗