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Biomedical subjects
Publications and source records attributed to C Campbell.
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Symptoms equated with "threatened" or "near-miss" sudden infant death syndrome (SIDS) were noted during feedings in 4 infants. In each case, barium esophagrams revealed dysmotility. Acute "near-miss" symptoms required cardiopulmonary resuscitation during esophagography in 2 infants. The authors suggest that esophageal dysmotility is a cause of "near-miss" SIDS and most likely is responsible for more fatalities than commonly realized. The cause-and-effect relationship is explained by a vagovagal reaction. Etiologies of esophageal dysmotility and possible prophylactic measures are discussed.
The authors review the relationship between esophageal dysfunction (dysmotility) and the unusual cardiopulmonary and neurological manifestations equated with the symptoms of the "near-miss" sudden infant death syndrome (SIDS). Six beagle puppies were studied to see whether esophageal irritation and dilatation could provoke any cardiac dysrhythmia. Some of the cardiographic irregularities observed in 10 of 11 trials occasionally precede fatal ventricular dysfunction. The authors conclude that esophageal irritation can be responsible for cardiac arrest and that one important cause of SIDS is esophageal dysmotility.
Characterization of transport kinetics involved in tissue folate supply has been limited by the inability to accurately measure the uptake and metabolism of folate by rapidly proliferating tissues. The present report describes a new animal model that uses subcutaneous fibrosarcoma implants as a target tissue for studies of folate supply. The fibrosarcoma grows rapidly as a well-encapsulated, nonmetastasizing nodule(s) and does not disrupt the animal's normal growth and nutrition. Moreover, the tumor nodules avidly take up labeled folate and can be removed easily by local excision for measurements of uptake and intracellular metabolism of folate.
Vocalizations were elicited in three anesthetized rhesus macaques by electrical stimulation of a site in the brain stem. At the same, the laryngeal muscles--cricothyroid (CT), geniohyoid (GH) and sternothyroid (ST)--were electrically stimulated to assess their effect on the elicited phonation. Analysis of the recorded vocalizations indicated that stimulation of each of the muscles produced a substantial increase in the voice fundamental frequency (Fo), with the CT muscle causing the greatest Fo increase. Maximum elevation in Fo was obtained when the CT muscle was stimulated simultaneously with the GH or ST muscles. Changes in Fo were typically accompanied by changes in voice quality.
Dilation of the ascending aorta and an intimal flap within it (indicating dissecting aneurysm) were visualized by M-mode and cross-sectional echocardiography, from the right but not from the left parasternal area. The diagnosis was confirmed by aortography and at surgery. Systolic flutter of the intimal flap, seen on M-mode echocardiography, was attributable to the jet from a mildly stenotic aortic valve impinging on it.
The case presented illustrates the potential of assessing fetal pulmonary maturity by analysing liquor draining vaginally after premature rupture of the membranes. The necessity of carrying out appropriate biochemical tests to detect contamination with maternal urine is emphasized.
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