[Body reaction to implanted carbon microparticles (author's transl)].
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Biomedical subjects
Publications and source records attributed to C Burri.
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The following approaches to the caval vein are applicable: Vena saphena, basilica, subclavia, and jugularis. Based on collective studies from the literature and our own experience, the puncture of the internal jugular vein is recommended. The approach via the veins of the lower extremities should no longer be used in adult. Many complications--independent of the approach--are caused by the catheter model applied or by poor application technique or care. A model of our own was developed presenting siliconized polyethylene and a removable needle. As compared to PVC, the rate of inflammation and thrombosis was significantly decreased.
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To test the endangered stability after obtaining cancellous bone from the greater trochanter, the ultimate breaking force of 40 human femura was measured with a material testing machine (Instron 1115). 1. 10 Femura after removing bone from the greater trochanter as a routine clinical procedure showed a significantly reduced trochanteric stability (p less than 0.05), 4 subtrochanteric and 3 pertrochanteric fractures, compared to 10 intact opposite femura with vertical shear fractures of femural neck and head without damage to the trochanteric region. 2. The number of fractures crossing the window was reduced by half, p less than 0.05 when a round cortical window compared to when a square window of the same area was cut. As the reduced stability caused by the remove of cancellous bone can not be avoided, we can clearly reduce the danger of stress concentration in the notches by cutting a round corticalis window. Cancellous bone from the greater trochanter should only used, if it cannot be taken from the brim or posterior iliac spine of the pelvis.
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The result of the experimental studies encouraged us to treat our patients with chondro-malacia patellae not only by superficially rasping the damaged cartilage, but also by drilling several holes down to the subchondral layer. This allows a type of tissue repair by connective tissue. In addition we prefer a section of the retinacula and an anteposition of the patella ligament.
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Epiphyseal lesions adjacent to the knee joint may result in disturbances of growth with subsequent changes of leg length and knee axis. Both conditions involving the weight-bearing lower extremities call for correction. Knowledge of the epiphysis' pathophysiology, the case history, and the actual situation compared to the contralateral extremity is the basis of management along with the command of physiologically reasonable as well as technically feasible operations. Final normalisation may be achieved by static correction using modern internal fixation techniques and bone grafts once growth is terminated. Serious axis deviations and leg length discrepancies exceeding 10 degrees and 3 centimeters respectively should, however, be corrected, even if growth is still in progress. It may be possible to eliminate the cause of deformation by removing an epiphysiodesis. Methods to accelerate growth have not been useful clinically. Temporary deceleration of growth by means of epiphyseal staples is justified in certain cases provided close follow-up is possible. Static correction as outlined will also produce the most dependable results if growth is still in progress.
Normal tissue defects in the tibiae of 16 sheep were filled with gelatine, collagen or a mixture of both. Comparable rates of new bone formation occurred after observation periods of 6 and 12 weeks. The difference is not statistically significant. In our experiment collagen and gelatine showed neither a positive nor a negative influence on new bone formation.
In order to find reliable criteria for determining the prognosis of transplanted cartilage, the quality of isolated rabbit chondrocytes was assayed in vitro. A culture system of semisolid medium was able to detect colony-forming units of chondrocytes. Also their proliferative and differentiating capacity could be investigated. Colony formation in vitro follows a strict dose-response relationship. An inverse relationship was observed between age of the donor and the colony incidence in vitro. Cells from neonatal cartilage could be induced to grow as fibroblastic colonies in the presence of conditioned medium from fibroblastic monolayer cultures. No effect, however, could be observed with chondrocyte-derived conditioned medium.
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