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Biomedical subjects

C Buckley

Publications and source records attributed to C Buckley.

81 records · Page 5Linked to original sources
PubMed1983

Automatic query formulations in information retrieval.

Modern information retrieval systems are designed to supply relevant information in response to requests received from the user population. In most retrieval environments the search requests consist of keywords, or index terms, interrelated by appropriate Boolean operators. Since it is difficult for untrained users to generate effective Boolean search requests, trained search intermediaries are normally used to translate original statements of user need into useful Boolean search formulations. Methods are introduced in this study which reduce the role of the search intermediaries by making it possible to generate Boolean search formulations completely automatically from natural language statements provided by the system patrons. Frequency considerations are used automatically to generate appropriate term combinations as well as Boolean connectives relating the terms. Methods are covered to produce automatic query formulations both in a standard Boolean logic system, as well as in an extended Boolean system in which the strict interpretation of the connectives is relaxed. Experimental results are supplied to evaluate the effectiveness of the automatic query formulation process, and methods are described for applying the automatic query formulation process in practice.

Computers↗
PubMed1983

Experience with highly purified porcine factor VIII in a patient with haemophilia A and a factor VIII inhibitor.

Highly purified porcine factor VIII has been advocated for the treatment of bleeding episodes in patients with haemophilia who have inhibitors to factor VIII. This approach has been successful in a patient with an intermediate potency inhibitor showing little cross-reactivity to porcine material. As in some other reported cases, a severe allergic reaction occurred on one occasion but did not preclude the subsequent use of the porcine concentrate in carefully controlled conditions.

Adult↗
PubMed1981

An Australian choroidal melanoma survey. Factors affecting survival following enucleation.

This study is based on a computer-assisted analysis 484 enucleated malignant melanomas of the choroid from The Royal Victorian Eye & Ear Hospital, Melbourne. The following factors which might influence survival were analysed; the sex and age of the patient, the interval between presentation for medical opinion and enucleation, the size of the melanoma and its position in the eye, the cell type of the melanoma and the presence of extraocular extension. From this analysis it was found that: 1) The overall 15-year relative survival rate following enucleation was 75%. 2) the survival curve flattened out at six years after enucleation indicating relatively few melanoma-related deaths for the remainder of the 15-year period. 3) there was no increase in death rate at 2 years after enucleation. 4) considering only melanoma-related deaths, increasing age is a strongly depressing influence on survival after enucleation, the 15-year relative survival being 80% for those less than age 40 and only 30% for patients aged 70 and over. 5) submacular melanomas had a very good prognosis for patient survival due in part to their small size and benign cytology. 6) extension into a scleral emissary appeared to exert an unexpectedly depressing effect on prognosis. 7) as in other published series, small melanomas tended to have a good prognosis, and survival rates diminished with increasing size. 8) there was possibility, to be further explored, that ciliary body melanomas may over all have a worse prognosis than melanomas of the choroid.

Adult↗
PubMed1979

The polyglandular failure syndrome: disease inheritance, HLA type, and immune function.

The occurrence of disease and the inheritance of histocompatibility leukocyte antigens (HLA) were evaluated in 11 patients with the polyglandular failure syndrome and 42 of their relatives. The gene frequency of the HLA-B8 allele (seven of 22) and the HLA-A1, B8 haplotype phenotype frequency (five of 11) were increased in patients with polyglandular failure as compared with a control population. Eleven of 42 relatives had a polyglandular failure illness. Disease prevalence correlated with HLA inheritance in some families, but not all. Patients and diseased relatives had a high incidenceof immunologic dysfunction: autoantibodies, including antinuclear antibodies; elevated serum immunoglobulins (three of 16); abnormal skin tests (four of nine). Polyglandular failure appears to be an HLA-B8-associated syndrome with a high prevalence of disease in relatives. Immunologic dysfunction resulting from a gene(s) on chromosome 6, in linkage dysequilibrium with the HLA-B8 allele, may be a factor in the pathogenesis of polyglandular failure illnesses.

Addison Disease↗
PubMedDate not supplied

Scabies management in the community.

BACKGROUND: Unidentified and undertreated cases of scabies are the source of continued spread. AIMS: To evaluate management of scabies in the community. METHODS: Eighty-six outpatient and ward referrals were reviewed. Fifty-six had previously applied scabicidal treatments (Group 1), whilst in 30 patients the diagnosis was made de novo (Group 2). Treatment failure was identified by a detailed questionnaire. In both groups, patients were reviewed at four to six weeks. RESULTS: Sixty-four per cent of Group 1 was initially correctly diagnosed. Seventy per cent of Group 1 patients had received verbal and written instruction as part of previous unsuccessful treatments. The clearance rate in the combined group treated according to protocol was 96%; 100% clearance was ultimately achieved. CONCLUSION: Inconsistency in diagnosis and treatment of patients is common. A treatment protocol should be made available to family practitioners.

Clinical Protocols↗
PubMedDate not supplied

Gianotti-Crosti syndrome in an infant following immunization.

Gianotti-Crosti syndrome (GCS) is a distinctive, self-limiting acropapular or papulovesicular eruption. Typical clinical presentation is that of a monomorphic, nonpruritic eruption most commonly involving the face, neck, buttocks, and extremities. It tends to occur in childhood, though infrequently it has been reported in adults. We report GCS occurring in an infant following immunization.

Acrodermatitis↗