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Biomedical subjects

C Bogdan

Publications and source records attributed to C Bogdan.

At least 127 records · Page 7Linked to original sources
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[Dysphonias. I].

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Adult↗
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[Dysphonias (II)].

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Diagnosis, Differential↗
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Circadian rhythm of beta-endorphin in the plasma of clinically healthy subjects and in patients with adrenocortical disorders.

Immunoreactive beta-endorphin was determined in the plasma of 37 elderly subjects (73 +/- 7 years of age), in 3 young or young adult subjects without adrenal disease, in 4 women with clinical adrenogenital syndrome, in 1 man with Cushing's disease. Immunoreactive beta-endorphin in plasma was measured by radioimmunoassay in six samples of each subject collected at 4-hour intervals over a 24-hour span. The observation of a circadian rhythm in circulating immunoreactive beta-endorphin with highest values during the late night and early morning hours is extended to elderly subjects in the 8th decade. The beta-endorphin plasma concentrations in the few clinically healthy young adult subjects studied fell within the same range. The circadian variation of the group of elderly subjects was used as reference in the clinical evaluation of plasma beta-endorphin concentrations in patients with pituitary-adrenocortical disorders. The need for circadian rhythm qualified reference values is shown by the observation of the circadian variations of circulating immunoreactive beta-endorphins in the patients with adrenogenital syndrome and Cushing's disease in whom abnormalities in the concentration of circulating beta-endorphin were found at certain circadian stages but not at others.

Adolescent↗
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Chronobiology of serum iron concentration in subjects of different ages at different geographic locations.

The circadian rhythm in serum iron concentration was studied in 61 elderly men (74 +/- 6 years of age) and 93 women (78 +/- 8 years of age) in Bucharest, Romania, in 81 clinically healthy boys and 103 girls (11 +/- 1.5 years of age) in Tîrgovişte, Romania, in 4 elderly men and 19 women (71 +/- 5 years of age) and in 75 young-adult men (24 +/- 11 years of age) and 52 women (24 +/- 9 years of age) in St. Paul, Minnesota, USA. Six samples were obtained from each subject around a 24-hour span. The sampling sessions in the elderly subjects in Romania and in the children extended over all four seasons. A circadian rhythm statistically verified by Cosinor analysis was evident in all groups in both locations. A statistically significant sex difference with lower circadian mean (mesor) and a lower amplitude in the women was found in the Romanian elderly subjects. The children in Romania showed no sex difference in any circadian rhythm parameters. The young adult subjects in Minnesota showed a significantly higher mesor and a phase delay in the men as compared with the women. The elderly subjects of both sexes at both geographic locations had a lower circadian mesor than the young adults and the children. In the Romanian elderly subjects also the circadian amplitude was lower, which was not the case in the Minnesotans. While the acrophase in the elderly subjects and in the children in Romania was comparable (0928 and 0932 local time resp.), the young adults in Minnesota showed in comparison to the Romanians a phase delay (1132 local time) and the elderly in Minnesota showed a phase advance (0732 local time) in comparison to all other groups. The latter finding will have to be confirmed by more extensive studies. In the elderly subjects in Romania the circadian rhythm in serum iron concentration was in phase with the circadian rhythms in total serum bilirubin and alkaline phosphatase but showed significant phase differences from the circadian rhythms in serum albumin, urea nitrogen (BUN), gammaglutamyl transferase (Gamma-GT), serum globulins, glucose, insulin and total serum proteins. The elderly subjects in Romania showed a statistically significant circadian phase delay in summer as compared to fall but showed no seasonal variation of the mesor. The children showed a circadian phase advance in fall as compared to the other seasons and a seasonal variation of their mesor with higher values in spring and summer as compared with winter and fall.(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗
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Circannual rhythms of systolic and diastolic blood pressure in relation to plasma aldosterone and urinary norepinephrine in elderly subjects and in children.

Sixty six elderly men and 87 elderly women 77 +/- 8 (S.D.) years of age were studied in 285 profiles consisting of measurements of systolic and diastolic blood pressure obtained at 4 hour intervals during the waking hours of the subjects for 2 or 7 days and (among others) plasma aldosterone and urinary norepinephrine determinations collected in six samples at 4 hour intervals during one 24-hour span. The profiles were spread through all four seasons. The circadian means were calculated for each profile by the single cosinor method and the circannual variations were analyzed by the Bingham test and analysis of variance. A circannual rhythm of the systolic and the diastolic blood pressure was found with a peak systolic pressure in spring and peak diastolic pressure in summer. A circannual rhythm in urinary norepinephrine was statistically significant only in the women with a peak in winter, out of phase with the circannual rhythm in blood pressure. In plasma aldosterone, the highest values were found during fall and winter with statistical significance reached at the p less than .05 level in the women only. In contrast to the elderly subjects, 87 boys and 107 girls 11 +/- 1.5 (S.D.) years of age studied by the same methodology over one 24-hour span each spread throughout the four seasons showed a circannual rhythm in systolic and diastolic blood pressure and in norepinephrine excretion with a peak during winter. A circannual rhythm of the circadian mesor of the plasma aldosterone concentration was found in the children with highest values in fall and lowest values in spring (when the blood pressure values also were lowest). With all qualifications in mind about possible causal relations between rhythms showing a coincidence or a difference in phase, it appears that there are certain differences in the circannual time structure of cardiovascular and related endocrine functions between children and elderly subjects which may be of clinical importance.

Aged↗
PubMedDate not supplied

Circannual rhythms of laboratory parameters in serum of elderly subjects. Evaluation by cosinor analysis.

A total of 189 elderly subjects 76 +/- 8 years of age were studied in 230 24-hour profiles consisting of six blood samples collected at 4 hour intervals. The sampling sessions were spread over all four seasons. The circadian means were analyzed by single cosinor analysis for the presence of circannual variations. Statistically significant circannual variations were found in men and/or in women in the serum concentrations of: albumin, total bilirubin, calcium, chloride, CPK, glucose, LDH, potassium, sodium, triglycerides, and uric acid. Only in few functions is the extent of the circannual rhythms in the variables presented here large enough to present potential diagnostic problems in today's practice of laboratory medicine. However, the seasonal variations in metabolic functions, or if endogenous in nature, circannual rhythms may be of physiologic and pathobiologic importance. There is a need to quantify certain of these rhythms as a predictable portion of variability in laboratory values, and presumably as an indicator of human health.

Adaptation, Physiological↗
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Chronobiologic observations of calcium and magnesium in the elderly.

Sixty-two elderly men (average age 75 +/- 6 yrs) and 85 elderly women (average age 79 +/- 8 yrs) institutionalized at Berceni Clinical Hospital, Bucharest, Romania, were investigated over a 24 hour span, some of them repeatedly, leading to a total of 269 profiles. The subjects were studied in 12 subgroups spread over all four seasons. Total serum calcium, inorganic phosphate, total protein, albumin and urinary calcium and magnesium were determined. Circadian rhythms were found in all variables. There were statistically significant phase differences between serum calcium, total protein and serum albumin speaking against the serum protein rhythm (or circadian variations in hydration) being responsible for the circadian rhythm in total serum calcium. There are phase differences between the elderly (and young) subjects studied in Romania and several series reported from Germany and the USA. Circadian and circannual variations were found for urinary calcium and magnesium excretion, with maximum in fall and low values during summer. The peak excretion thus follows, rather than coincides, with the time of maximum sun exposure. The elderly subjects studied in Romania show a relatively low circadian (24-hour) mean calcium excretion, and the circadian acrophase in the elderly occurs during the night hours in keeping with the acrophase shift found in elderly subjects in urine volume and other electrolytes.

Aged↗
PubMedDate not supplied

Differences in the circadian rhythm parameters of urinary free epinephrine, norepinephrine and dopamine between children and elderly subjects.

The circadian rhythm in the urinary excretion of free epinephrine, norepinephrine and dopamine was studied in 60 elderly men and 83 women, 77 +/- 8 years of age, in a total of 260 24-hour profiles and in 63 boys and 81 girls, 11 +/- 1.5 years of age, in 144 24-hour profiles. The circadian mesor of all these compounds was increased in the children over that in the elderly subjects while the acrophase remained unchanged in spite of a phase shift of the acrophase of the urine excretion of the elderly in the night hours. The differences in functional state of the sympathetic and adreno-medullary function (and/or response) between children and elderly subjects may have clinical implications.

Aged↗