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Biomedical subjects

C Beck

Publications and source records attributed to C Beck.

At least 163 records · Page 9Linked to original sources
PubMed1983

[Functional results of stapes surgery].

In 135 patients the functional results of stapedotomy and stapedectomy were controlled. As a rule, stapedotomy results were superior to stapedectomy results. Small hole stapedotomy using a 0.4 mm. teflon-wire piston yielded optimal sound transmission between 500-8000 Hz. In addition, this was the only technique to prevent cochlear damage at 4000 Hz and 8000 Hz.

Adult↗
PubMed1983

[Otalgia].

Based on the sensibel innervation of the external and middle ear, the causes and therapy of otalgia are discussed. As a result, the classical definition of otalgia: "pain in the auricular area without concomitant ear pathology" should be maintained.

Cranial Nerve Diseases↗
PubMed1983

[Obliteration of the mastoid cavity with porous tricalcium phosphate ceramic. Results 12 and 18 months after ceramic implantation in the hypotympanon of the pig].

The paper reports on the obliteration of mastoid cavities with resorbable tricalcium phosphate ceramic. As a model, we chose the pneumatic air cell system of the pig's hypotympanon, which resembles the human mastoid. At the time of surgery, the specimens were 10-12 weeks old. In a first group the cells of the hypotympanon were totally removed and the operation cavity was obliterated with adjacent layers of porous tricalcium phosphate ceramic. In a second group of specimens the air cell system was partly removed, leaving the apical part of the hypotympanon intact; the operation cavity was obliterated again with porous tricalcium phosphate ceramic. After 12 and 18 months survival the hypotympanons were removed and prepared for histological investigations. Those ceramic plates, lying close to the bony shell were strongly resolved and replaced by new bone. Other ceramic plates, however, especially those in the center of the implant, showed few signs of resorption and bony remodelling. Inside the ceramic implant there was hardly connective tissue. The space between the still unsolved ceramic plates was filled up with new bony tissue. This bone was partly structured and adjoined directly to the ceramic. The ceramic was integrated into the new bony tissue without any sign of an inflammation.

Animals↗
PubMed1983

[Resorbable, porous tricalcium phosphate ceramic in middle ear surgery. Initial clinical results].

In our experimental study in the pig we could demonstrate that resorbable, porous tricalcium phosphate ceramic material is suitable for an obliteration of mastoid cavities (respectively the hypotympanon of the pig) or for the reconstruction of bony wall. To examine this material in a clinical study for middle-ear surgery, we chose 2 mm thick ceramic plates and segments of truncated cones. With the aid of a diamond drill and irrigation this ceramic can be treated easily. In 25 middle ears, the following reconstructive surgeries were performed with these ceramic implants: in 22 cases a partial replacement of the lateral attic wall, in one case a replacement of the total lateral attic wall, in one case a reconstruction of the canal wall after radical mastoidectomy, and in one case an obliteration of the mastoid cavity. These 25 ears have been followed up for 2-11 months with an average of 7,1 months. In 19 cases the implants showed no sign of any complication. In four cases, however, a dehiscence of the skinny covering (outer ear canal) was observed during the post-operative healing period. In one case this dehiscence closed spontaneously, in the other case we recovered the implant by surgery. In one patient we had to remove the implant, in another one the implant is uncovered and still under observation. An inflammation of the implant bed occurred once. One implant sank down into the middle ear cavity.

Animals↗
PubMed1982

[Carcino-embryonic antigen and beta 2 microglobulin in malignant bone diseases. 61 cases (author's transl)].

Radioimmunological assays of carcino-embryonic antigen (CEA) and beta 2 microglobulin were carried out in 61 cases of malignant bone disease, including myeloma and metastases from carcinomas of the breast and prostate. CEA assays seemed to be of greater interest in mammary cancer metastases and beta 2 microglobulin assays in prostatic cancer metastases and myeloma. The correlation which appeared between CEA levels of the outcome of breast cancer metastases was of assistance in adjusting treatment. Combining CEA and beta 2 microglobulin assays would enhance their usefulness in current practice.

Beta-Globulins↗
PubMed1982

Only one gene is required for the glpT-dependent transport of sn-glycerol-3-phosphate in Escherichia coli.

Deletion and point mutants defective in the glpT-dependent sn-glycerol-3-phosphate transport system were isolated and located on the Escherichia coli chromosome. They mapped in glpT in the clockwise order gyrA, glpA, glpT at around 48 min on the Escherichia coli linkage map. The mutations within glpT were ordered by deletion mapping, three factor crosses, and by crosses involving lambda transducing bacteriophages carrying glpT-lac operon fusions. Results obtained using these fusion phages indicated that glpT is transcribed in the counterclockwise direction on the E. coli linkage map. Complementation analysis using these mutants revealed only one complementation group. Thus, one gene is necessary and sufficient for the proton motive force-dependent sn-glycerol-3-phosphate transport system.

Biological Transport↗
PubMed1982

Interstitial radiotherapy with 198Au seeds in the primary management of carcinoma of the oral tongue: results in Freiburg/Breisgau from January 1964 to July 1980.

Thirty-two patients with histologically proven carcinoma of the oral tongue, Stage T1-3, were analyzed retrospectively. They were treated from January 1964 through July 1980 in Freiburg by interstitial implantation with Au-198-seeds for the primary tumor management. Out of 25 patients with complete follow-up, one patient developed a local recurrence. In three patients, regional lymph node metastases occurred, once after prior adjuvant radiotherapy to the regional lymph nodes area, and in two patients after exclusive interstitial radiotherapy to the tumor of the tongue. The overall five-year survival rate was 52% for all stages (overall group), 75% for Stage T1 and 44% for Stages T2-3. The corrected five-year survival rate was 75% for all stages, 86% for Stage T1 and 71% for Stages T2-3. The method of 198Au-seed implantation as it is practiced in Freiburg is discussed, as well as the radiation exposure of the personnel.

Adult↗
PubMed1982

[Sandwich irradiation of patients with squamous cell carcinoma of the tonsil, the base of the tongue and the hypopharynx].

Taking into account the death rate of all other causes for that age group and comparing the survival time and the recurrence rate in patients with preoperative short-time irradiation with telecobalt 60 and a focal dose of 20 Gy with a second group of patients treated with postoperative radiotherapy, we were unable to detect any advantage of the so-called "sandwich therapy" in cancer of the tonsils, the base of the tongue or the hypopharynx. On the contrary: patients with "sandwich therapy" had to be hospitalized longer because of the interval between preoperative radiotherapy and surgery and because of the delay in restoring postoperative speech and deglutition.

Carcinoma, Squamous Cell↗
PubMed1982

[Are porous tricalcium phosphate ceramics suited for the replacement of bony walls in ear surgery? An animal experiment study of the hypotympanum of the domestic swine].

The purpose of this study was to examine the possibility of a partially or totally posterior canal and lateral attic wall reconstruction with a more stable and therefore less porous tricalcium phosphate ceramic plate (S8). The hypotympanon of 4 pigs was drilled out, leaving the bony shell intact. In the middle part of this cavity a 2 mm thick S8-ceramic plate was placed horizontally. The hypotympanon of further 11 pigs was drilled out and obliterated with a more porous tricalcium phosphate ceramic (S5). Additionally, a single S8 ceramic plate served as a wall to the cavum tympani. 1 to 18 months after operation the pigs were sacrificed; sections of the hypotympanon were investigated with light microscopy. After few weeks, the S8-ceramic plate was covered by granulation tissue and epithelium on the tympanic side. After three months newly formed bony tissue could be observed between the peripheral parts of the S8-ceramic plate and the tympanic epithelium. After six months both sides of the S8-ceramic plate were completely covered by new bone; moreover this bone is covered by the mucosa on the tympanic side. At this time the S8-ceramic plate has a tight bony contact to the shell of the hypotympanon and bone growth can be observed in the macropores of this plate. The bony layer on the tympanic side of the S8-ceramic plate remained slim, there was no exophytic growth after 12 months. After 18 months the S8-ceramic plate shows distinct signs of resorption and bony replacement. However, in comparison to the S5-ceramic this occurs slower and later.

Animals↗
PubMed1981

A contribution to the pathogenesis of cholesteatoma. A histochemical and ultrastructural study.

In a histochemical and ultrastructural study the pathogenesis of cholesteatoma ostitis is analysed on human tissue. In the subepithelial layer there is evidence of an inflammatory reaction leading to proliferation of granulation tissue with bony invasion. Bony destruction is initiated by osteocytic osteolysis. In the case of cholesteatoma there is a combined action of extraosseous and osseous lysosomal enzymes. The pathological changes of the fibrillar elements suggest that the self-perpetuation of degeneration is maintained by a disturbance of fibrillogenesis. The causal pathogenesis of cholesteatoma formation is discussed as a function of a disturbance between cellular activity, extracellular matrix, and cellular surface.

Cholesteatoma↗
PubMed1981

[The origin of efferent fibers to the inner ear on reptiles. A HRP study in Caiman crocodilus (author's transl)].

The origin of efferent fibers to the inner ear was studied in Caiman crocodilus. After injection of horseradish peroxidase into the basilar papilla or into the ampullae of the horizontal and anterior semicircular canals, neurons labeled by the granular reaction product of retrogradely transported HRP were found in the medulla oblongata bilaterally. Parent cells of the efferent cochlear bundle were found in the medial reticular nucleus and in the rostroventral division of the superior olive bilaterally. Efferent vestibular neurons were found in the medial reticular nucleus bilaterally with more neurons ipsilateral to the injection site.

Alligators and Crocodiles↗
PubMed1981

[The auditory pathway in guinea pigs. A [14C]2-deoxyglucose study (author's transl)].

The auditory pathway of guinea pigs was labeled with [14C]-deoxyglucose after mon- or binaural stimulation with farfield white noise in a sound-proof chamber. In the autoradiographs, all auditory nuclei were labeled. The highest metabolic effects were seen in the dorsal cochlear nucleus, the lateral superior olivary nucleus, and in the inferior colliculus. No selective labeling was observed in the auditory cortex. Monaural stimulation depressed the metabolic activity contralaterally in the ventral cochlear nucleus and ipsilaterally in the medial nucleus of the trapezoid body, the dorsomedial periolivary nucleus, and in the inferior colliculus.

Acoustic Stimulation↗