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Biomedical subjects

C Beck

Publications and source records attributed to C Beck.

At least 307 records · Page 17Linked to original sources
PubMedDate not supplied

Absorbable and nonabsorbable sutures in microsurgery: standardized comparable studies in rats.

In order to study the applicability and value of synthetic absorbable suture materials in microvascular surgery, 8-0 monofilament nonabsorbable polyamide sutures and 8-0 absorbable polyglycolic acid and polyglactin 910 sutures were used in end-to-end anastomoses of the aorta in rats, employing the same microsurgical model for all procedures. Comparable investigations of the anastomotic sites were carded out macroscopically and histologically at various intervals postoperatively. It was found that when placed under unphysiologic strain, microvascular anastomoses sutured with absorbable materials had less mechanical endurance than anastomoses stitched with nonabsorbable suture materials. It was also found, however, that this had no significance in vivo, inasmuch as no vascular ruptures or aneurysms appeared with either the absorbable or nonabsorbable sutures even after long-term observation. The nonabsorbable sutures were fully recognizable up to 150 days, microscopically showing clear evidence of granuloma formation. The absorbable sutures, on the other hand, could hardly be discerned after 50 days, and after 150 days the foreign body and scar reactions had almost completely disappeared. Absorbable suture materials lead to more rapid restitution of the vascular wall than nonabsorbable sutures and consequently appear to be superior.

Absorbable Implants↗
PubMedDate not supplied

Obtaining and maintaining a research sample with cognitively impaired nursing home residents.

Obtaining and maintaining a research sample of cognitively impaired nursing home residents is a challenging task. One cannot conduct research with this population without the cooperation of the nursing home administration and staff. The initial challenge is identifying and screening potential subjects. The medical record often provides inadequate information, necessitating direct observation and use of screening tools. Once potential subjects have been identified, the researcher must obtain consent. This complicated process may vary from site to site. Because of the potential subjects' cognitive impairment, we must obtain additional consent from a proxy. A variety of persons may function as proxy. Suggested methods of contact include personal contact at the nursing home and phone or written contact. Proxies may raise many issues in deciding whether to consent.

Aged↗
PubMedDate not supplied

[Malignant melanoma in the child--2 case reports].

Case histories of two infants with malignant melanoma are presented. Both tumors had developed from a congenital mole to advanced disease with lymph node metastasis at time of diagnosis, findings which are commonly correlated with poor outcome. Initially, both patients were surgically treated. From the experience with few described cases of melanoma in childhood and with a large number of adult patients, neither chemotherapy and conventional BCG immunotherapy nor irradiation seem to be an effective treatment and are accompanied by many adverse side effects. Therefore in one patient therapy was limited to surgery alone. In the other child it was followed by treatment with high-dose recombinant alpha-2-interferon (1 Mill. i.u./Kg X d) plus an H2-receptor antagonist. Unexpectedly this girl developed neurological side effects, characterized by spastic paraparesis, indicating damage to the first motoneuron. All symptoms completely resolved after discontinuation of drugs within three months. Both children have been in complete remission for 18+ and 32+ months, respectively.

Cell Transformation, Neoplastic↗