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Biomedical subjects

C Beck

Publications and source records attributed to C Beck.

At least 217 records · Page 12Linked to original sources
PubMed1978

10 years of experience with intratympanally applied streptomycin (gentamycin) in the therapy of Morbus Menière.

During the last 10 years a total of 83 patients with severe cases of unilateral Morbus Menière were treated in our clinic. The proposed therapy was to administer streptomycin (gentamycinsulfate) intratympanically by applying two different ways of procedure. In the first group of 40 patients we attempted to destroy the vestibular organ without harming the cochlea whereby we avoided surgical intervention. In the second group of 43 patients we integrated more recent findings in the pathophysiological mechanism underlying the pathogenesis of Morbus Menière into our therapeutic considerations and attempted to exclusively destroy the secretorial epithelium with minimal dosages of aminoclycoside antibiotics. The results after treatment were clearly better for the second group of patients.

Cochlea↗
PubMed1978

[Ultrastructural morphometric changes in spiral ganglion cells of the rat after broad band noise (author's transl)].

The comparison of ultrastructural and ultrastructural-morphometric findings in spiral ganglion cells subsequent to broad noise with 105 dB SPL over a period of 40 min demonstrates that there are morphometric changes of the cytoarchitecture of granular ganglion cells even without evident ultrastructural changes. Morphometric analyses shows a significant extension of the volume proportion of mitochondria per unit volume cytoplasm. The volume and the surface of the rough endoplasmic reticulum, the volume of the free ribosomes and the average single volume of the nucleoli increase per granular ganglion cell. The physiologic significance of these changes is discussed. The results show that changes of the cytoarchitecture of granular spiral ganglion cells are earlier detected by morphometry than by ultrastructural description.

Acoustic Stimulation↗
PubMed1978

A simple procedure for surgical repair of vocal cord synechia.

With a simple method performed since 1962 on six patients for the correction of anterior vocal cord synechia, a paladon granule reinforced with a thread is brought into the larynx from outside after severance of the synechia. With convalescent treatment of the cartilaginous frame, it lies in the anterior commissure for 6 weeks. After endoscopic removal, free glottis and good voice. Tracheotomy is not necessary.

Humans↗
PubMed1978

[Xenogenic transplantation of aortic segments. Korrelated serological and histological investigations of the rejection mechanism].

With CDF inbred strain rats and randomly bred guinea pigs one syngenic control group and two xenogenic experimental groups were examined. The two xenogenic groups had different transplantation sites of aortic segments, the first of which was orthotoply retroperitoneal, the second heterotoply subcutanous. The following results were obtained: 1. A xenogenic vessel graft induces a massive production of antibodies after the fifth day, reaching a maximum on the 42nd day, and slowly and continuously decreasing thereafter. The tissue of the graft becomes acellular within 12 to 24h p.op. After 5 to 6 days an infiltrate appears, firstly dominated by granulocyts and monocyts and later by lymphocyts and plasmacells. Following the continuous destruction of the elastic fibres aneurysms grow. 2. The two xenogenic groups show that these two transplantation sites have no significance for the humoral response. 3. Both the progress of the antibodytiters (strong increase after the fifth day) after transplantation of aortic segments and the acute and chronical histologic changes suggest an immunological mechanism of hyperacute rejection.

Animals↗
PubMed1978

[Presbycusis (author's transl)].

This study is base on 438 patients (age 45-99), 250 women and 188 men, divided into decades from 45 to 95 years. Mean hearing levels were measured at 63 up to 12000 Hz using the atlas pure-tone audiometer. Statistical analyses helped estimating the influence of various anamnestic datas on sensorineural hearing loss. 65 patients with diabetes had no hearing loss related to their disease. In 115 noise-exposed patients 'correction for noise' was 5 to 7 dB at 2000 and 4000 Hz. There was no difference in men and women at any frequency and any age group. 'Average presbycusis' in the literature today is too positive. Starting age 20, a linear progressive hearing loss for all frequencies ranging from 6 to 18 dB per decade can be detected, being less for the lower than for the higher frequencies.

Adult↗
PubMed1978

[Surgical or conservative treatment in orbital complications of sinus inflammations (author's transl)].

47 patients with orbital complications resulting from acute sinusitis have been treated at the Freiburg ENT Department during the last seven years. Acute ethmoiditis predominated in children, while pansinusitis was more common in adults. Previous sinus surgery did not prevent orbital complications arising from the same sinus. Orbital involvement was classified into periostitis, subperiosteal abscess and orbital cellulitis. According to clinical findings, 44.7% of the patients were managed conservatively. Prognosis was best in periostitis, whereas consersative treatment was unsafe in orbital cellulits. Children usually respond well to appropriate antibiotic coverage but the occurrence of common upper respiratory or anaerobic pathogens should be kept in mind.

Adult↗
PubMed1977

[Tonsillectomy and age (author's transl)].

We evaluated the case histories of 149 patients aged over fifty who were tonsillectoprived in our ENT-clinic in Freiburg between May 1970 and April 1975. Neither the rates of damages nor of complications were higher than those of younger patients. If necessary, even older patients can be operated.

Age Factors↗
PubMed1977

Liability of ultrasound in maxillary sinus disease.

For the first time liability of of ultrasonography in diagnosing paranasal sinus disease was controlled in 256 patients with acute maxillary sinusitis as compared to irrigation findings and in 150 patients with persistent maxillary sinus disease using x-rays, sinoscopy and sinumanometry as controls. Confidence in diagnosing the presence of discharge ranges up 90%. In cases of total opacity of the sinus, ultrasonography helps differentiating mucosal swelling, tumor and discharge.

Acute Disease↗
PubMed1977

[Experience with the inlaytechnic of tympanoplasties type I. (author's transl)].

After more than ten years of experience with the inlaytechnic of tympanoplasties type I at the ENT-department of the University of Freiburg, and evaluating tha datas of 451 consecutive ears operated between 1970 and 1974, this technic proved to be good. The quote of recidive-surgery was about 19.9%. Hearing improved markedly in 80.4% of the patients. Complications like the appearence of Cholesteatoma, lateral migration of the transplant or flatening of the anterior tympanomeatal angle have not been noticed.

Evaluation Studies as Topic↗
PubMed1977

[Anatomical conditions influencing the therapy of the inner ear (author's transl)].

Morphological factors affecting the course of disturbances of the inner ear are demonstrated. Its important to realise that damaged sensory cells may recover quite a long time after injury. The blood supply and its regulation, possibly by autonomic innervation, are significant in the treatment of the inner ear. The reported findings must be regarded as the combined effort of numerous factors (Biology of the inner ear).

Animals↗
PubMed1977

[Bacteriological findings in chronic infantile tonsillitis (author's transl)].

Under general anaesthesia cultures were taken from infantile tonsils prior to T & A. The bacteriological results and the serological classification of hemophilus are questionning literature reports. According to our findings one must consider haemophilus influencae as a resident of the common oral flora. There was no significant difference culturing tonsils with or without repeated antibiotic treatment. Hemophilus influencae combined with beta-hemolytic streptococci is common. Immunological considerations against infantile T & A, based on bacteriological observations are questioned.

Anti-Bacterial Agents↗
PubMed1976

[Aerosinusitis (author's transl)].

After distinguishing a nonobstructive from an obstructive form of aerosinusitis, different pathological changes are discussed. Two cases illustrate the possibility of endoscopic removal of submucous sinus hematomas. Nonobstructive aerosinusitis may be due to highly viscous paranasal secretion. In obstructive sinus disease intranasal application of vasoconstrictors may prevent additional aerosinusitis. In 71 patients with obstructive frontal and maxillary sinusitis, aerosinusitis followed a negative sinus pressure of 66 mm Hg and 35 mm Hg respectively. Intranasal application of a vasoconstrictive and antiexsudative solution for prophylaxis of aerosinusitis lead to an increase of negative pressure tolerance of 47-57 mm Hg.

Adult↗