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Biomedical subjects

C Bazin

Publications and source records attributed to C Bazin.

At least 91 records · Page 5Linked to original sources
PubMed1985

Elimination kinetic of high polar metabolites pool of quinidine from human serum.

The elimination half-life of high polar metabolites pool of quinidine (t1/2 beta = 6.1 h) has been determined in a quinidine phenobarbiturate intoxicated patient after the complete elimination of quinidine (its precursor) from blood. It is equivalent to the generally accepted t1/2 beta of quinidine (6.1 +/- 1.8 h) but substantially different from the t1/2 beta "hybrid" of 3-hydroxyquinidine (10.0 h) determined in therapeutic conditions in which 3-hydroxyquinidine coexists with quinidine in blood. With regard to the low serum level of quinidine and strong ECG impairments, it is speculated that high polar metabolites of quinidine taken as a whole could be involved in this life threatening intoxication.

Barbiturates↗
PubMed1984

[Prognostic value, at the onset of an asthma attack, of respiratory, hemodynamic, and acid-base equilibrium parameters].

Sudden death is still a common complication of acute asthma. The authors analysed statistically the prognostic value of the respiratory rate (RR), the heart rate (HR), blood gases, systolic blood pressure (BP syst), and diastolic pressure (BP diast) and the amplitude of the P wave in lead II on the ECG, recorded at the beginning of the asthma attack. This retrospective study concerns two groups of patients distinguished on the basis of the severity of the attack (group I: simple retrospective study concerns two groups of patients distinguished on the basis of the severity of the attack (group I: simple attack; group II; status asthmaticus). A HR greater than 24 per minute, a P wave greater than or equal to 2.5 mm or a PaCO2 greater than or equal to 6.3 kPa (47.25 mmHg) are three highly sensitive and specific criteria of the evolution of the asthma attack towards a more severe form (status asthmaticus). Patients who present one or more of these parameters should be monitored in a respiratory intensive care unit in order to prevent avoidable sudden death.

Acid-Base Equilibrium↗
PubMed1984

[Case of cortical deafness sparing the music area].

A 33-year-old woman had developed cortical deafness with profound initial deafness lasting for eleven months after pneumococcal meningitis ten years previously. CT scan demonstrated bilateral temporal lobe lesions, predominantly on the left side where it extended into the adjacent parietal and frontal lobes. Audiometry suggested integrity of the internal ear and brain stem. Early auditory evoked potentials were present, while potentials of moderate latency and delayed potentials were abolished. Neuropsychological investigations demonstrated total absence of spoken language, contrasting with conservation of written language, though with agrammatism and an impossibility of identifying non-verbal noises, spoken language, and music. The patient could not identify rhythms, pitch, melodies or the different types of music. The musical quality of sound stimuli and musical pleasure were, however spared as shown by recognition of tape recorded sound stimuli with written denomination and designation of images in multiple choice tests. The relations between auditory agnosia, "pure" verbal deafness and cortical deafness are discussed. Reported cases are reviewed and an attempt is made to demonstrate the existence of several levels in the integration of musical stimuli, the most elementary of which could be the perception of the musical quality of sounds, as was the case in the present patient.

Adult↗
PubMed1983

[Gougerot-Sjögren syndrome, periarteritis nodosa, non-Hodgkin's lymphoplasmocytic lymphoma and acquired C4 deficiency].

A Sjögren syndrome was confirmed histologically in a 19 year old woman. Four years later, periarteritis nodosa (PAN) with characteristic vascular lesions on muscle biopsy occurred simultaneously with lymphatic hyperplasia comprising splenomegaly and polyadenopathy. The PAN was cured with corticosteroids and cyclophosphamide and the lymphadenopathy regressed. Several months after treatment was stopped the lymphadenopathy recurred which histologically resembled a malignant non-hodgkin lymphoplasmocytoma secreting an IgM kappa monoclonal immunonoglobulin. During the PAN and the establishment of the lymphoproliferative syndrome a severe C4 deficit was detected which disappeared after chemotherapy.

Adult↗
PubMed1983

[Edematous cerebellar infarction in the young subject].

A 19 years' old white male presented with a stuporous state, initially suspected to be of a toxic origin. It appeared soon that the patient had a left oedematous cerebellar infarction with obstructive hydrocephalus. The angiographic study has shown an occlusion of the left vertebral artery at the level of C2. After reviewing the literature about the different etiologies of vertebral occlusions in the young people, it appeared likewise that, in this case, it was the result of a traumatic compression due to an alcoholic coma. Despite an external ventricular drainage, the neurological state worsened. After a left suboccipital craniotomy and resection of the external part of the cerebellar hemisphere, the state of the patient improved quickly, and he was discharged from hospital with a light cerebellar syndrome.

Adult↗
PubMed1982

Severe meningitis due to Listeria monocytogenes. A review of 40 cases in adults.

During a 10-yr period, 40 cases of severe Listeria monocytogenes meningitis were observed. All patients showed consciousness disturbances and 27 of them (68%) focal neurologic signs. Cranial nerve palsies were common (57%). Early general seizures (13 patients) and presence of underlying disease (12 patients) were associated with a high mortality rate. Although the management of antibiotic therapy is open for discussion, chloramphenicol (used in 7 patients) seems to be more effective than other drugs.

Adult↗
PubMed1982

[Granular cell tumor of a cerebral hemisphere: value of gliofibrillary protein acid assay].

A patient with a left parieto-occipital tumor presented generalized convulsions, and aphasia with alexia and agraphia. Diagnosis was confirmed by CT scan. Partial excision only was possible and was followed by radiotherapy. Histology showed the tumor to be composed of moderate and large sized cells with a granular PAS+ cytoplasm. Protoplasmic astrocytes were numerous at the periphery. Electron microscopy demonstrated typical features of Abrikossof's granular cell tumor: heterogeneous granulations constituted mainly of secondary lysosomes, autophagic vacuoles, multivesicular bodies, and rare angular bodies. The granular cells were interspersed with astrocytes, the feet of which were implanted on the capillary basal membrane. Immunoperoxidases assay of gliofibrillary protein acid demonstrated high levels in the intercellular prolongations, considered here to be astrocytic, but weak concentrations in the granular cells. This suggests uptake by the latter cells of adjacent astrocytic gliofibrillary protein acid, especially as the action of an anti-albumin serum on the tumor demonstrated that the granular cells can take up extracellular proteins by a passive mechanism. These findings stand against an astrocytic origin of the tumor. Comparison with other granular cell tumors, particularly pituicytomas, provides evidence of morphological unity, but cerebral granular cell tumors are rich in astrocytes, whereas these are absent in pituicytomas. The oncogenic unity of these tumors has not been established.

Brain Neoplasms↗
PubMed1977

[Encephalitis localised in the brain stem and of indetermined etiology. 6 cases].

The authors report six cases of encephalitis localised in the brain stem. This disease occurred frequently during 1975, with the following symptoms and signs: fever, paralysis of several cranial nerves, temporary mental disturbance and C.S.F. changes. Several patients required tracheotomy and aritificial respiration. All patients recovered without any recurrences. Viral studies were negative. The possibility of a Listeria infection cannot be entirely eliminated.

Acute Disease↗