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Biomedical subjects

C B Smith

Publications and source records attributed to C B Smith.

At least 253 records · Page 14Linked to original sources
PubMed1972

In vitro studies of the combined effect of ampicillin and sulfonamides on Nocardia asteroides and results of therapy in four patients.

The minimal inhibiting concentrations (MIC) of ampicillin, trisulfapyrimidines, and various combinations of these drugs were determined for four clinical isolates of Nocardia asteroides on Mueller-Hinton agar. The combination of ampicillin and sulfonamides was found to be synergistic for three of the four isolates when an inoculum of 10(3) to 10(4) organisms per ml was used. (Synergism was defined as occurring when the MIC of each of the drugs in combination was one-quarter or less of the MIC of each drug alone.) All four isolates were inhibited by concentrations of the drugs in combination that were clinically achievable. Combined therapy with ampicillin and sulfonamides was used in four immunologically suppressed renal transplant patients who had pulmonary infection with N. asteroides. Clinical improvement was noted within 2 weeks in all patients, and the pulmonary infiltrates cleared by 6 months in three patients. One patient died from an unrelated illness 10 days after starting therapy. The disease was arrested in two patients who were maintained on full immunosuppressive therapy.

Adolescent↗
PubMed1972

In vitro activity of tobramycin and gentamicin.

The in vitro antimicrobial activity of tobramycin and gentamicin was compared against 362 bacterial isolates. The minimal inhibitory concentration (MIC) of tobramycin was fourfold less than the MIC of gentamicin against most of 119 Pseudomonas organisms. Gentamicin and tobramycin had similar in vitro activity against Enterobacteriaceae and Staphylococcus aureus. Proteus rettgeri were commonly resistant to both tobramycin and gentamicin. The 10-mug tobramycin disc separated resistant (MIC >/=5 mug/ml) and susceptible (MIC <5 mug/ml) organisms in 359 of 362 tested. In disc diffusion testing, the tobramycin and gentamicin zone diameters were found to vary significantly with concentrations of magnesium ions in the media employed. The MIC of tobramycin varied with the size of the inoculum, and tobramycin was most effective at a neutral pH.

Aminoglycosides↗
PubMed1972

Mycoplasma-virus interrelationships in mouse tracheal organ cultures.

The effects produced by single and mixed infections with Mycoplasma pulmonis and influenza A/PR-8 virus were studied in mouse tracheal organ cultures. M. pulmonis multiplied in the tracheal organ cultures, producing inhibition of ciliary activity and histologic tissue damage. The organism grew in close association with the cell membranes but did not appear to attach directly to the membranes or the cilia. Influenza A virus also replicated in tracheal organ cultures, producing ciliary inhibition and more extensive cytopathologic changes. Virus particles were seen by electron microscopy to attach to and cause clumping of the cilia. Simultaneous infection of the organ cultures with mycoplasma and virus resulted in more rapid inactivation of ciliary activity and greater tissue damage than occurred when the cultures were infected with only mycoplasma or virus. Presence of the virus appeared to have no effect on the growth of the mycoplasma; however, the mycoplasma partially interfered with virus replication.

Animals↗
PubMed1972

Growth of Newcastle disease virus and rubella virus in rheumatoid and nonrehumatoid synovial cell cultures.

Rheumatoid and nonrheumatoid synovial cell cultures were challenged with Newcastle disease virus and rubella virus in an attempt to confirm reports that rheumatoid synovial cells are relatively resistant to infection with these viruses. Newcastle disease virus caused complete cell destruction by day 7 in both rheumatoid and nonrheumatoid cultures, and peak virus titers were similar. Rubella virus replicated in both rheumatoid and nonrheumatoid synovial cell cultures, and no consistent differences in virus titers were detected. Rubella-infected cell lines were observed for up to 28 days and no virus-specific cytopathic effect was seen.

Adolescent↗
PubMed1971

Gettin' it together.

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Education, Nursing, Associate↗
PubMed1970

Tolerance to morphine-induced increases in [14C]catecholamine synthesis in mouse brain.

Morphine sulfate increased the incorporation of carbon-14-labeled tyrosine into labeled catecholamines in the mouse brain. Tolerance was manifested by a shift to the right in the dose-response curve for morphine after mice were treated repeatedly with morphine. Naloxone, a specific morphine antagonist, also shifted the dose-response curve for morphine to the right.

Animals↗