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Biomedical subjects

C B Smith

Publications and source records attributed to C B Smith.

At least 235 records · Page 13Linked to original sources
PubMed1976

Relations between age, mineral density and mechanical properties of human femoral compacta.

Relations between mineralisation and mechanical properties have been investigated in human femoral compacta. Evidence of age-related changes in physical properties of bone, independent of mineral density, is provided by significant (P less than 0.05) partial correlation between ultimate tensile stress and age. However, 75 per cent of variance in ultimate tensile stress, and 85 per cent of variance in ultimate compressive stress could be accounted for by variation in mineral density.

Adult↗
PubMed1975

The relation between sub-capital fracture of the femur and mineral content of the right third metacarpal.

Positive correlation between the mineral content of the mid site of right third metacarpal and neck of femur has been established using the psi-ray absorption technique described by Shimmins et al. (1972b) to make measurements on excised human bones. An X-ray method (Anderson, Shimmins and Smith, 1966; Shimmins et al. 1972a) was used to measure the mineral content of the right third metacarpal in 101 female and 22 male patients with subcapital fracture of the ferum. When their metacarpal "whole bone densities" were compared with those of control subjects of the same age and sex, they were found to have significantly lower (P smaller than (0.025) average values. However, groups of patients defined according to Garden's classification of severity of fracture could not be distinguished one from the other on the basis of metacarpal whole bone density measurement.

Adult↗
PubMed1975

A comparison of the effects of morphine and forced running upon the incorporation of 14-C-tyrosine into 14-C-catecholamines in mouse brain, heart and spleen.

Morphine increases both the locomotor activity of mice and the incorporation of 14-C-tyrosine into 14-C-catecholamines in the mouse brain. To determine whether a relationship exists between increases in locomotor activity and increases in catecholamine synthesis, mice were treated with either morphine (100 mg/kg i.p.) or saline and were forced to run on a treadmill (5.4 m/min). When mice were given saline and forced to run, incorporation of 14-C-tyrosine into 14-C-catecholamines was increased over control values in the heart and spleen but unchanged in the brain. When mice were given morphine, but not forced to run, the incorporation of 14-C-tyrosine into 14-C-catecholamines was increased over control values in the brain but unchanged in the heart and spleen. Morphine decreased the catecholamine content of the mouse brain but not of the heart or spleen. Forced running did not change the catecholamine content of any tissue. The differences between the effects of morphine and forced increases in locomotor activity upon the incorporation of 14-C-tyrosine into 14-C-catecholamines and upon the catecholamine content in various tissues of the mouse indicate that the effects of morphine on catecholamine synthesis are not the result of changes in locomotor activity.

Animals↗
PubMed1974

Acute and chronic morphine treatment and the hydroxylation of (1-14C)-L-tyrosine in the mouse brain.

Tyrosine hydroxylase activity in slices of caudate nucleus was increased by morphine (100 mg/kg i.p.) administered to naive mice. During chronic treatment with morphine tolerance developed to this effect and 36 h after the final chronic morphine injection there was a decrease in enzyme activity in this area. There was no change in tyrosine hydroxylase activity in slices of diencephalon, brainstem or parietal cortex from either naive or morphine tolerant mice. There- fore, changes in tyrosine hydroxylase activity, measured in vitro, could account for the changes in dopamine synthesis, but not noradrenaline synthesis, produced by morphine in vivo.

Animals↗