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Biomedical subjects

C Anastasatu

Publications and source records attributed to C Anastasatu.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[The efficacy of ethambutol compared to streptomycin in the initial quadruple phase of short-term regimens].

In order to test comparatively SM and EMB efficacies within quadruple regimens of short-term chemotherapy, two groups of patients with pulmonary tuberculosis at first treatment, sputum positive under microscopic examination, were constituted through randomization. One group (59 cases) was submitted to the standard regimen RHSZ 2/7, and the other (61 cases) to RHZE 2/7. Group structure was homogeneous from the standpoint of case repartition, according to the anatomo-radiological form, therapeutical regimen, and sensitivity to Tb drugs. Both bacteriological and radiological clinical evolutions show, even in the conditions of a short-time interval (2 months), a similar efficacy of SM and EMB within the quadruple regimens in the initially intensive phase of anti-Tb treatment. It is possible that the results may be dependent upon the concomitantly bactericidal action of: rifampicin, hydrazide and pyrazinamide. Therefore, a further testing of the comparative efficacy of the triple regimen RHZ 2/7 with the quadruple RHSZ 2/7 and RHZE 2/7 during a longer follow-up is required.

Drug Evaluation↗
PubMedDate not supplied

[Use and evaluation of radiophotography in the ambulatory care of lung diseases].

In the methodological cabinet for pneumology of the Institute of Phtysiology, radiophotography was employed in the following fields: a) screening of acute and chronic pneumopathies as appears from : the increase in the number of cases of non-specific pneumopathies as compared with cases of tuberculosis and the quantitative contribution of the method reflected in the fact that over 80% of the cases with non-specific pneumopathies were detected by radiophotography; b) diagnosis -- by comparing with the data recorded in the files, multiple incidences (front, posterior lordosis, profile); locally pointed (targeted) photographs, rf quantified functional tests in cases suspected of C.O.B.P.: c) follow-up of the evolution of dispensary cases and of the therapeutical effect; d) scientific research and teaching activities through epidemiological and pathogenesis studies, thus allowing for a valorification of the files over a 16 years period. The use of the radiophotographic method in the activity of a cabinet of pneumology is necessary especially because it allows for an early detection, a superior morphological diagnosis, as compared with radioscopy (fluoroscopy), for an objective and economical follow-up of the cases, providing at the same time material for scientific research and teaching demonstrations.

Ambulatory Care↗
PubMedDate not supplied

[Study of adverse reactions in pulmonary tuberculosis patients treated with rifampicin].

The present study concerns the clinical appraisal of adverse reactions reported in the course of Rifampicin (RMP) treatment, reactions which have given rise to conflicting reports. The lot studied included 243 cases of pulmonary tuberculosis of which 57 were treated according to the 7/7 regime (600 mg RMP), 152 according to the 2/7 regimen (900-1200 mg RMP) and 34 according to the 7/7 followed by the 2/7 regimen. Tolerance to RMP was followed up by a series of adequate tests and close clinical surveillance. Adverse reactions developed in 31.5% to 41.5% of the cases in terms of the treatment scheme. In the intermittent treatment adverse reactions occurred in 17.1% of the cases.

Chemical and Drug Induced Liver Injury↗
PubMedDate not supplied

[The Cu/Fe ratio and its significance in the pathogenesis, diagnosis and prognosis of bronchopulmonary cancer].

In 197 cases with various bronchopulmonary affections, iron was dosed in serum, according to Weippel's method, and copper, according to Cantarov's method. Cu/Fe serous ratio was found in the normal patients between 0.7 and 1.7 higher than the control sample were reached (1.2); in OCBP the ratio was twice versus the control sample (2.62 versus 1.2). In the disease diagnosis and prognosis, the determination of the Cu/Fe serous ratio is suggested in those suspected of bronchopulmonary cancer. The increase of the ratio shows the aggravation by metastases, and the improvement after operations indicates the lack of metastases. The advantages of the test are: sensitivity, specificity, predictability, economy.

Bronchial Neoplasms↗