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Biomedical subjects

C Adams

Publications and source records attributed to C Adams.

At least 235 records · Page 13Linked to original sources
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US food legislation.

Explore the source record for details and available documents.

Food Contamination↗
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Primary thalamic and caudate hemorrhage in term neonates presenting with seizures.

Two previously well term neonates who presented with seizures are described: one with thalamic hemorrhage and the other with thalamic and caudate hemorrhage. These 2 patients were the only neonates found with thalamic hemorrhage in a review of 54 term infants with intracranial hemorrhage at The Hospital for Sick Children over a 10 year period (1976-1986). Partial seizures occurred at 5 and 7 days after birth and were easily controlled. Prognosis was generally good in these 2 patients, as well as in 4 previously reported patients.

Caudate Nucleus↗
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Spinal cord birth injury: value of computed tomographic myelography.

The value of myelography in the assessment of spinal cord injury in the early neonatal period has not been documented, although this study has been recommended frequently in the literature. Eight neonates are reviewed who presented with the clinical features of spinal cord injury and who had myelography performed. Clinical features included difficult delivery, absent respiration, flaccid paralysis, sensory level, and neurogenic bladder. Myelography revealed that 7 patients had the early changes of swollen cord and 1 patient had the late changes of cord atrophy. None of the neonates had surgical intervention. One neonate died at 3 days of age, while 2 others died after prolonged ventilation. Of the 5 infants who survived, 3 still require ventilation and have spastic quadriparesis, 1 has almost recovered completely and 1 had spontaneous respiration and limb movement but brisk deep tendon reflexes when last examined at 1 month of age. Myelography, which was performed in the early neonatal period in our infants, was abnormal in all patients. Myelography is useful in confirming the diagnosis, outlining the level and extent of the lesion, and excluding extramedullary compression. Myelography may assist in the assessment of prognosis but did not alter management in our patients.

Birth Injuries↗
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Comparison of SPECT, EEG, CT, MRI, and pathology in partial epilepsy.

Twenty children with partial epilepsy who had surgery between the ages of 4 1/2 months and 18 years were studied preoperatively with electroencephalography (EEG), computed tomography (CT), and technetium-99m hexamethylpropyleneamineoxime 99mTc-HmPAO single photon emission computed tomography (SPECT; 20 interictal, 4 postictal). Fourteen had magnetic resonance imaging (MRI). All had an epileptiform focus (12 unilateral, 8 predominantly unilateral) on EEG. The combination of interictal and postictal regional cerebral blood flow (rCBF) abnormalities alone correlated with EEG foci in 16 of 20 patients. Interictal rCBF abnormalities correlated with EEG foci in 14 of 20. CT findings correlated with EEG foci in 14 of 20. MRI findings correlated with EEG foci in 13 of 14. Pathology demonstrated tumor in 6, cortical dysplasia in 4, mesial temporal sclerosis in 3, Sturge-Weber in 2, cavernous hemangioma in 1, Rasmussen encephalitis in 1, porencephalic cyst and gliosis in 1, and cysts found at surgery (but normal histology) in 2. Interictal and postictal SPECT, EEG foci, and CT findings each correlated with the pathology site in 17, 19, and 15 patients, respectively. MRI correlated with pathology site in 13 of 14 patients. Postictal and interictal abnormalities of rCBF correlated with EEG and pathology as frequently as CT. In 5 patients with normal CT scans and in 1 with a normal MRI, postictal and interictal rCBF correlated with EEG and pathology results; however, these 6 patients all had abnormalities on CT or MRI. SPECT, therefore, may be considered a valuable additional diagnostic procedure in the evaluation of epilepsy surgery candidates in that it adds to the evidence of abnormality at the involved site.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
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Sex determination by PCR analysis of DNA extracted from incinerated, deciduous teeth.

Establishing the biological sex of human remains is a very important part of identifying victims of fire when severe soft tissue destruction has occurred. Deciduous (children's) teeth were exposed to a range of incineration temperatures 100-500 degrees C for 15 minutes. Polymerase Chain Reaction (PCR) amplification was used to identify specific human amelogenin regions. There was successful identification of human biological sex, from deciduous teeth exposed to incineration temperatures of 200 degrees C and below, using standard ethidium bromide gel staining. There was greater sensitivity using fragment analysis by laser induced fluorescence which achieved sex identification from some teeth heated to 400 degrees C.

DNA↗
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Phonological awareness therapy and articulatory training approaches for children with phonological disorders: a comparative outcome study.

Sixty-one children, aged 3.6-5.0, with developmental phonological disorders (PD) participated in a study comparing the effects of metaphonologically (MET) or articulation-based (ART) therapy. Maturational effects were controlled for by the inclusion of 59 normally speaking control children of the same age range. Measures of phonological (speech) output and phonological awareness were taken before and after therapy for all subjects and at 3 months post-therapy for PD children. Results showed that PD children improved significantly in both phonological output and awareness skills across the intervention period compared with control children, but that there was no significant difference on the awareness measure between ART and MET groups. ART and MET groups differed from each other on one measure of speech improvement only, with the ART group making more change than the MET group on individual probe scores. Follow-up measures for both therapy groups indicated that there was little difference between the groups on phonological awareness change or speech development 3 months after intervention, though there was a trend for MET children to continue to make more long-term change than the ART group on one output measure. Additional analysis showed that there were generally few significant implications for outcome between PD children with good initial phonological awareness skills and those who initially had poor phonological awareness skills.

Articulation Disorders↗
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Women's beliefs about "natural" hormones and natural hormone replacement therapy.

OBJECTIVE: To assess women's beliefs about natural hormones, including what they believe the term "natural" means, and their beliefs about the risks, side effects, and efficacy of natural hormone replacement compared to standard hormone replacement. DESIGN: Eighty-two women completed a 20-item survey available at a local compounding pharmacy. Respondents were white (100%), middle-aged (mean age, 47.22 years), and college educated (95.1%); 32.9% were perimenopausal, and 50.0% were postmenopausal; 58.5% were currently using hormone replacement therapy and, of those, 77.1% were using human bio-identical hormones. RESULTS: Ninety percent of the respondents ( n = 74) reported that they had heard about natural hormones. Of those, most believed natural meant plant-derived (44.6%) and/or not synthesized or made without chemicals (50.0%). Most reported hearing about natural hormones from a healthcare provider (66.2%) and/or magazines and books (55.4%). When compared with standard hormone replacement, most respondents endorsed the beliefs that natural hormones have fewer or no risks (71.4%), have fewer or no side effects (69.0%), and are equally or more effective for managing menopause symptoms (61.8%). In addition, many endorsed the beliefs that natural hormone replacement is equally or more effective than standard hormone replacement for protection against osteoporosis (47.1%) and heart disease (40.0%), although many endorsed "don't know" for bone (45.7%) and heart (54.3%) protection. CONCLUSIONS: Among women responding to a survey in a compounding pharmacy, most believed that, compared with standard hormones, natural hormones are safer, cause fewer side effects, and are equally or more effective for symptom management. Many believed natural hormone replacement is equally or more effective for long-term bone and heart protection. Educating women on the nature, risks, and benefits of natural hormone therapy is recommended.

Adult↗
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Breastfeeding trends at a Community Breastfeeding Center: an evaluative survey.

OBJECTIVE: To evaluate the Community Breastfeeding Center's (CBC) impact on clients' breastfeeding experiences. DESIGN: Retrospective survey; participants were mailed a questionnaire. SETTING: A hospital-based drop-in center operated jointly by the Wellington-Dufferin-Guelph Health Unit and Headwaters Health Care Center and offering professional breastfeeding support and peer interaction. PARTICIPANTS: The 164 mothers of singleton births, both inpatients and community clients, who attended the CBC during a 10-month period in 1996-1997 and completed a survey. MAIN OUTCOME MEASURES: A mailed survey with forced-choice and open-ended questions. RESULTS: Of the respondents, 90.9% rated their overall CBC experience as excellent or good. Seventy-three percent of respondents breastfed for 4 months or longer. Primiparae and mothers of preterm infants tended to visit the CBC more frequently, while achieving duration rates similar to other subgroups. Returning to work was the reason most frequently cited for stopping breastfeeding (35%). CONCLUSION: The CBC is an effective community support strategy to lengthen breastfeeding duration and enhance clients' satisfaction with their breastfeeding experience.

Adolescent↗
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The effects of ice massage on delayed muscle soreness.

The following hypotheses were tested in the present study: (1) cryotherapy would reduce delayed muscle soreness (DMS) in eccentrically exercised muscles; (2) early cold treatment would reduce this soreness more than later postexercise treatment times; and (3) joint range of motion (ROM) would be inversely related to the subjective soreness ratings. Subjective sensations of muscular soreness and changes in elbow joint ROM were assessed in 30 subjects at 0, 24, 48, and 72 hours following eccentric-biased exercise in the elbow flexors. Cold treatments were applied immediately, 24 or 48 hours following a single exercise session. In response to the eccentric exercise, significant muscle soreness increases and elbow ROM decreases were observed in all exercised muscles from 24 to 48 hours postexercise. No differences in muscle soreness or elbow ROM changes were observed between treated and untreated arms except for one. Subjects treated at 24 hours postexercise reported greater soreness in their arms compared to untreated arms just prior to treatment (24 hour postexercise). The results do not support the efficacy of cold in reducing DMS. A negative correlation between muscle soreness and elbow ROM at 48 and 72 hours postexercise indicated that an increase in soreness was associated with a decrease in ROM.

Adult↗
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Memory functioning among midlife women: observations from the Seattle Midlife Women's Health Study.

OBJECTIVE: As the number of midlife women increases, there is an increased interest in women's experiences of the perimenopause. Because of the evidence linking estrogen with cholinergic and serotonergic activity in the brain and with central nervous system development of dendritic arborization, and mixed evidence of estrogen use with incidence of Alzheimer's disease, the effects of the perimenopause on memory functioning are of interest. The purpose of these analyses, part of the Seattle Midlife Women's Health Study, was to describe changes in women's perceived memory functioning according to their perimenopausal group, age, perceived stress, health status, and mood. DESIGN: Memory functioning was assessed with the Memory Functioning Questionnaire as part of a questionnaire mailed to study participants annually. Perimenopausal group was assessed using Mitchell's rating schema. RESULTS: Age was unrelated to any of the Memory Functioning Questionnaire indicators except for retrospective memory; younger women reported more memory problems than older women. Perimenopausal groups were unrelated to most memory functioning ratings with few exceptions. Memory functioning ratings of current memory compared with the past were worse for women who were in early and middle transition and for those who were using hormone therapy than for those who were in late transition and postmenopause. Women reported more current memory problems compared with 10 and 20 years ago and at age 18. Health ratings were negatively correlated with memory functioning ratings, and depressed mood positively correlated with nearly every indicator of memory functioning (frequency of memory problems, ratings of current memory, past memory, and memory change). Greater perceived stress levels were associated with more memory problems. CONCLUSIONS: Perceived memory functioning seems more closely related to perceived health, depressed mood, and perceived stress than to perimenopausal stage or age. Further work is needed to determine whether these ratings provided by the Seattle cohort will change over time as women age and as they make the transition to menopause and beyond.

Adult↗
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Clinical diagnostic and intervention studies of children with semantic-pragmatic language disorder.

The diagnosis of semantic-pragmatic language disorder (SPLD) has been the subject of a number of research studies over the last two decades. Classification and diagnostic debates, while illuminating, have done little to develop tools to improve services to these children. In this paper, two children whose communication difficulties are suggestive of an SPLD diagnosis but who have differing profiles are studied. Using existing models of psycholinguistics and pragmatics to guide assessment and intervention, the diversity of language and social communicative behaviours that are covered by the label SPLD are exemplified. Consideration is given to whether the term SPLD is appropriate for both children or whether Bishop's revision of the diagnosis to 'pragmatic language impairment' might be more useful. Methods of intervention and evaluation for semantic and pragmatic deficits in these two cases are described. It is argued that existing tools can enable accurate explanation and modelling of the communication of children with SPLD and that there is a role for intervention studies in helping to refine those tools, to improve therapies and to understand the nature of the condition more fully.

Child↗