[Effects of prolonged administration of thyrocalcitonin in human senile osteoporosis. Clinical, histological and radiographic study].
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Biomedical subjects
Publications and source records attributed to C A Baud.
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In subcutaneous calcinoses induced in rats by topical calciphylaxis and topical calcergy, the ultrastructural aspects related to the evolution of calcified deposits were previously described. In the present study by means of X-ray diffraction, infrared spectrometry and electron spin resonance, different biophysical analyses are performed on the mineral substance deposited during development of calciphylaxis and calcergy. A rapid evolution of the calcium phosphate deposits into hydroxyapatite was noticed along the first 20 days of the calcinoses; from then, there is no important modification even at the later stages, and the characteristics of the mineral substance are mostly similar to that of bone tissue. The concentration of trace elements such as Mg2+ and Fe2+, is found higher in cutaneous calcinoses than in bone tissue.
An investigation of three groups from ancient populations (Neolithic, Early Middle Ages, Middle Ages) was performed on 273 adult skeletons. Despite unequal preservation of the remains, a study of a series of large joints and spinal segments permitted some conclusions: rheumatoid arthritis, ankylosing spondylitis, and osteoarthrosis of large joints (hip, knee, shoulder) were not found. The main findings were: osteoarthrosis in spinal zygapophyseal joints (particularly at cervical level); intervertebral osteochondrosis (particularly at the cervical and lumbar levels); Schmorl's nodes (particularly at the thoracic and lumbar levels); enthesopathic osteophytes (particularly in the spine, iliac crest, patella, and calcaneus). Such deformities seemed more frequent in the Middle Ages than in the Neolithic period.
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