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Biomedical subjects

C A Baud

Publications and source records attributed to C A Baud.

At least 55 records · Page 3Linked to original sources

Diffuse enthesopathic hyperostosis--anatomical and radiological study on a macerated skeleton.

Anatomico-radiological study of a macerated skeleton in a 43-year-old diabetic woman. An important spondylosis with hyperostosis of the cervical, thoracic and lumbar vertebrae was seen. There were associated changes of insertional hyperostosis at various levels, particularly at the iliac crests. Paget's disease of the left iliac crest was also noted in the corresponding hyperostosis. This case presentation offers an opportunity to discuss local mechanical factors (observed at the tendinous insertions) as well as generalized considerations on the "terrain" of diabetes and perhaps malnutrition. It also demonstrates the interest that an anatomico-radiological comparison on macerated specimens can have for certain osteoarticular research, teaching and paleopathology.

Adult↗

Effects of hormones on osteocyte function and perilacunar wall structure.

Microradiographical and ultrastructural aspects of periosteocytic lacunae are determined by osteocytic activity, lacunar modeling and perilacunar miniremodeling in particular. The miniremodeling activity is constituted by two alternating processes: osteolysis and osteoplasis. Modifications of lacunar shape and size and of perilacunar wall ultrastructure, caused by a direct or indirect effect of certain hormones on osteocytic activity, were observed. The lacunar modeling alterations, particularly in cases of VDH or PTH deficiency, result in an irreversible impaired calcification of the lacunar walls and consequently, mottled lacunae. The alterations of periosteocytic osteolysis are characterized by an increase in number of enlarged lacunae and/or by increased magnitude of this lacunar enlargement. Usually observed as an effect of PTH and VDH, these alterations can also be induced by GC, T4, PG. On the other hand, CT causes a decrease in periosteocytic osteolysis. Periosteocytic osteoplasis is characterized by perilacunar bone formation of various aspects and is known to be stimulated by CT. The osteocytic response to hormones is a function of concentration and not of time; it is transient and not integrative. It can be concluded that none of the perilacunar wall modifications observed is characteristic of any particular hormonal effect or metabolic bone disease.

Calcitonin↗

Tendon calcifications in chondrocalcinosis. A clinical, radiologic, histologic, and crystallographic study.

Fine linear extraarticular calcium deposits were found in X-rays of 7 of 52 patients with articular chondrocalcinosis (ACC). Seven Achilles tendons, seven quadriceps tendons, and one plantar fascia were affected. In a control group of comparable age and sex, without ACC but with generalized osteoarthritis, no calcifications were found in the tendons. On a biopsy specimen of Achilles tendon with such calcium deposits, X-ray diffraction showed that they had the characteristics of calcium pyrophosphate dilhydrate. Isolated small foci of crystals were observed on some segments of tendon bundles. The presence of fine linear calcifications on X-rays of the Achilles or quadriceps tendons may be a useful aid in the radiologic diagnosis of so-called articular chondrocalcinosis.

Achilles Tendon↗

Minor elements in bone mineral and their effects on its solubility.

Mineral substance deposited in bone tissue when either strontium or fluoride are present, is both qualitatively and quantitatively different from that deposited in their absence. The presence of these ions causes not only heteroíonic substitutions in the crystalline lattice of the apatite phase, but also important modifications of the percentage of crystalline mineral, of crystal size and perfection, and of quantity of mineral per unit volume. These modifications affect the in vitro and in vivo demineralization of bone tissue.

Animals↗

[Industrial fluorosis].

43 potroom workers (aluminium industry) with fluorosis have been compared with 18 foundry workers of the same age, but who had never been exposed to fluorides. Clinical examination revealed a higher incidence of articular pain and limitation of motion in the exposed group. The diagnosis of fluorosis is not only clinical but calls for other investigations such as urinary fluoride determination, bone radiology and, above all, bone biopsy for fluoride determination, histology and microradiography.

Aged↗

[Biophysical and ultrastructural aspects of an implant-bone interface].

The study of the interface between implant and bone suggests that the ideal material should not be chosen the most inert, but on the contrary among materials apt to provoke the formation of a connective layer between bone and implant. Certain ceramic materials have these required properties.

Animals↗

[Anatomopathology of Paget's disease. Combined approach by conventional methods and ultrastructural study].

Paget's disease is manifested by bone remodelling where the rate of the resorption-osteogenesis pattern is abnormally enhanced. This leads to the formation of a pathologically structured bone. The bone remodelling does not concern the entire skeletal structure and is unequally active. It is limited by the neighbouring healthy bone in which it can spread out. It can be followed by the development of a sarcoma. When the acetabulum or the femoral head are affected this can occasionally, lead to a coxopathy with cartilage deterioration. An anatomo-pathological study of Paget's disease is necessary for understanding the basis and the limits of biopsy diagnosis as well as its various manifestations (clinical, radiological, biological, scintigraphical, thermographical). This study also serves as a basic for pathogenic discussion.

Aged↗