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Biomedical subjects

B Woggon

Publications and source records attributed to B Woggon.

At least 55 records · Page 3Linked to original sources
PubMed1983

Multimethodological approach in psychiatric predictor research.

The discussion of some methodological problems of predictor studies led to the following conclusions: 1. Different outcome criteria result in a different classification of patients as responders or non-responders. 2. Predictor variables and outcome criteria should be better defined. 3. The clinical relevance of a result can be estimated by calculating the proportion of explained variance. 4. Cross validation of results is necessary. 5. Changes during a test therapy of 10 days result in a relatively reliable prediction of outcome in acute schizophrenia and depression.

Antidepressive Agents↗
PubMed1982

[Scale construction of the German version of the Comprehensive Psychopathological Rating Scale (CPRS)].

170 hospitalised patients (96 schizophrenic, 71 depressive, and 3 manic) were examined during the German version of the CPRS. Based on factor analytical results four subscales ('manic syndrome', 'schizophrenic syndrome', 'depressive syndrome', and 'side-effects') and two second-order scales ('manic-depressive syndrome' and 'schizophrenic syndrome') were constructed. The first three subscales show a good reliability. The fourth subscale ('side-effects') has an insufficient internal consistency, mainly due to the small number of items (6). The two subscales 'schizophrenic syndrome' and 'depressive syndrome' and the two second-order scales can differentiate very well between schizophrenic and depressive syndromes. The validity of the first and fourth subscale could not be examined in this study.

Adolescent↗
PubMed1982

[Interrater reliability of the German version of the Comprehensive Psychopathological Rating Scale (CPRS)].

The interrater reliability of the German version of the CPRS was examined in 30 patients (18 schizophrenic, 11 depressive and 1 manic). All patients were examined by the same two raters. The agreement of 55 out of 65 items was determined using the kappa coefficient. Kappa was calculated concerning symptom present/not present and differences less than or equal to 2/difference greater than 2.49 or 54 items show a moderate to excellent agreement. Items based on self-rating have a better interrater reliability than items based on the rating of the psychiatrists. The interrater reliability of the syndromes was calculated, using the rank correlation coefficient. The agreement concerning the 4 primary and the 2 second-order factors is high or excellent. The good results show the usefulness of the CPRS for the assessment of psychopathological findings.

Adult↗
PubMed1980

[Psychopathologic changes during 20 days of antidepressive or neuroleptic therapy].

A retrospective study of 266 patients treated with neuroleptics and 130 patients treated with antidepressants divided the patients according to a global assessment after termination of therapy into responders and non-responders. The two groups were compared in respect to their psychopathological symptoms as assessed by the AMP system on days 0, 5, 10 and 20. Keeping the initial findings, comparable responders and nonresponders showed statistically significant differences in the target syndrome from the 5th day onwards. The same applied to the findings on the 20th day (end result of treatment). The improvements found at the several points of testing, expressed as a percentage of the overall improvement after 20 days, show that the major part of the total improvement has taken place already after the first 10 days. The statistically significant changes were examined as to their practical relevance by giving their declared variance as a proportion of the total variance.

Adolescent↗
PubMed1980

[Stability of the factorial structure of the AMP system during treatment].

The stability of the factorial structure of the AMP system was studied during the course of psychopharmacological treatments (day 0, 5, 10, 20) of 396 patients mainly suffering from endogenous psychoses. The analysis was based on a reduced item pool of 52 items, which occurred on day 20 in at least 10% of the patients. For the 9-factor solution the factorial structure was stable during treatment for the apathetic, the hallucinatory-desintegrative and the retarded-depression syndrome as well as for the hostility syndrome. The other five AMP syndrome showed no stable structure during the treatment. On the other hand the factorial structure of the 2-factor-solution was found to be stable on day 0, 5, 10 and 20 without exception. These results should be considered when using the AMP system for the documentation of syndromes during the course of therapeutic trials.

Adolescent↗
PubMed1979

[Interrater reliability of diagnosis, AMP syndromes and AMP symptoms (author's transl)].

Psychic disorders can be classified into three levels: symptom, syndrome, and diagnosis. For each of these levels of reference, interrater reliability has been calculated. For this purpose, 48 patients (25 depressives and 23 schizophrenics) were interviewed by two raters each and the diagnoses were registered on the AMP system (forms 3 and 4). Additionally, each rather made an ICD diagnosis. With ICD numbers of three digits interrater reliability amounted to Kappa = 0.84; with ICD numbers of four digits it amounted to Kappa = 0.65. According to the degree of accuracy, numerical agreement with the AMP syndromes lies between Kappa = 0.61 and 0.85. Single symptoms had the lowest reliability (median: Kappa 0.45 and 0.53). Reasons for these differences and possibilities for improvement are discussed.

Adolescent↗
PubMed1979

Comparison between Comprehensive Psychopathological Rating Scale (CPRS) and association for methodology and documentation in psychiatry (AMP) system.

1. 5 AMP experienced raters examined 28 depressed and 22 psychotic patients. Symptoms were documented using the CPRS (preliminary German translation) and the AMP system. The two rating scales were compared from the raters point of views and using descriptive statistical methods. 2. The high number of CPRS symptoms showing significant correlations to AMP symptoms demonstrate a strong similarity between the two rating scales. 3. The AMP system gives a more differentiated and comprehensive picture of the psychopathology than the CPRS. 4. The CPRS seems to us to be easily communicable, mainly due to the exact description of the scale steps and the differentiation of reported and observed items. 5. For the measurement of changes during treatment half steps should be used to increase the sensitivity of the CPRS.

Adult↗
PubMed1979

[Discontinuation of neuroleptics in chronic schizophrenics. I. Summary of the literature].

Based on the available publications on the discontinuation of antipsychotic drug treatment in chronic schizophrenic patients the following conclusions can be drawn: (1) About 50% of chronic schizophrenic patients develop a psychotic relapse after discontinuation of antipsychotic drug treatment. (2) The risk for a psychotic relapse after neuroleptic withdrawal seems to be less pronounced in older patients with a long duration of illness and hospitalization who are treated with a rather low maintenance dosage of antipsychotic drugs. (3) For the individual patient the effects of discontinuation are only predictable based on earlier results of an individual termination of his antipsychotic drug treatment.

Antipsychotic Agents↗
PubMed1979

[Influence of diagnosis, hospital and sex on the effects of bromperidol].

Based on the data analysis of the AMP-findings of 78 schizophrenic patients from 4 clinical trials, the following effects of Bromperidol could be demonstrated: a strong antipsychotic effect with an early onset (after 3 days), little sedation, good improvement of accompanying depressive symptoms, little autonomic but rather strong extrapyramidal side effects. No differences between the effects in men and women were noticed. Differences between the patient populations of two hospitals were small in comparison to the differences between the patients with catatonic and paranoid schizophrenia. In catatonic patients, Bromperidol had a stronger antipsychotic effect and showed an earlier onset of its effects.

Adult↗
PubMed1979

[Discontinuation of antipsychotic drugs in chronic schizophrenic patients. II. Psychological and psychopathological test differences between patients with and without relapse].

After the discontinuation of the neuroleptic treatment (open design), 10 out of 30 hospitalized chronic schizophrenic patients showed before the end of 4 weeks a significant increase of their symptomatology. This deterioration made the application of neuroleptics necessary. Before the discontinuation of the neuroleptic treatment the group of patients with later relapse and the group without relapse showed only slight differences concerning psychopathological symptoms but significant differences concerning test performance. After 2 weeks without medication a pronounced impairment of performance was found in patients with later relapse. At this time the two groups showed no more significant differences in the psychological tests. At the same time significant differences concerning the psychopathological symptoms had developed.

Adult↗
PubMed1979

[The development of psychopharmacotherapy].

Based on experiences during the longterm treatment with psychotropic drugs the following subjects are discussed: extrapyramidal side effects of neuroleptic drugs, cardiovascular side effects of antidepressants, side effects of Lithium, interactions with other medications, influence on laboratory tests and also the psychopharmacological treatment during pregnancy.

Abnormalities, Drug-Induced↗
PubMed1979

[Evaluation of AMP symptoms in independent and self assessment].

11 co-workers (9 physicians, 2 psychologists) of our research department with experience in the use of the AMP system participated in this study. According to the level of observation, 139 AMP symptoms were classified into 3 categories. 44 symptoms were classified into category SB (self-rating), 51 into category FB (psychiatrists' rating) and 44 into category SF (mixed rating). This showed the combination of different levels of observation in the AMP system. The symptoms of the 3 categories show an unequal distribution among the 9 AMP syndromes according to Baumann. The classification of the different symptoms according to the level of observation should be demonstrated during training sessions with the AMP system. This could avoid uncertainties in the judgement of AMP symptoms and improve the inter-rater reliability of the AMP system.

Humans↗