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Biomedical subjects

B Watt

Publications and source records attributed to B Watt.

At least 73 records · Page 4Linked to original sources
PubMed1987

Going for a dip?

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Humans↗
PubMed1986

Is ciprofloxacin active against clinically important anaerobes?

The comparative activity of ciprofloxacin against 272 clinical isolates and reference strains of anaerobes was determined by an agar dilution method. The majority of strains of Bacteroides fragilis and clostridia were resistant (MIC greater than 2 mg/l). The effect of pH, inoculum size and medium composition was also studied; the activity of ciprofloxacin was decreased at acid pH and by increasing inoculum size but was unaffected by the composition of the test media. Ciprofloxacin should not be used for the treatment of anaerobic infections because of its limited in-vitro activity against these organisms.

Anti-Bacterial Agents↗
PubMed1986

Pathogenic anaerobic bacteria of man.

A range of anaerobic bacteria may be pathogenic to man. Those of particular clinical significance are reviewed and prospects for their control by antibiotic therapy discussed.

Bacteria, Anaerobic↗
PubMed1985

The comparative in-vitro activity of cefotetan against anaerobic bacteria.

The in-vitro activity of cefotetan, a new cephamycin, was assessed against a total of 336 strains of anaerobic bacteria by means of an agar dilution procedure and compared with that of cefoxitin, mezlocillin, piperacillin, clindamycin and metronidazole. Overall clindamycin and metronidazole were the most active of the test compounds. Cefotetan showed good activity against anaerobic cocci and clostridia, except for Clostridium difficile (MIC90 = 16 mg/l), although it was comparatively less active than the other beta-lactams against anaerobic cocci. In the case of the Gram-negative anaerobes, cefotetan showed moderate activity comparable to that of cefoxitin; against the 120 test strains of Bacteroides fragilis both cefotetan and cefoxitin were markedly more active than the penicillins. In studies with antibiotic combinations, cefotetan + cefsulodin showed marked synergy (FIC index less than 0.3) against the majority of strains of Bact. fragilis tested.

Bacteria, Anaerobic↗