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Biomedical subjects

B V Stromberg

Publications and source records attributed to B V Stromberg.

At least 37 records · Page 2Linked to original sources
PubMed1985

Retreatment of previously treated hand infections.

Presenting patient profiles and bacteriologic culture and sensitivity data from 132 patients representing a 5-year experience with hand infections were examined. Patients were subdivided into those having no prior treatment and those having previously been treated with antibiotics. Presenting patient profiles showed the majority of patients to be young to middle-aged males. Temperature, pulse, and white blood cell counts, while usually mildly elevated, were usually not diagnostic. In comparison with patients not having been previously treated, patients having already received antibiotics with persistent or recurrent infections showed more of a tendency toward mixed infections. Anaerobic, mycobacterial, and fungal infections were also increased. Antibiotic susceptibility studies showed the cephalosporins and clindamycin maintain a reasonably good coverage (78% and 72%, respectively). Penicillinase-resistant antibiotics also provided some coverage in two thirds of patients. Proper antibiotic therapy may depend on several factors including previous treatment. Other measures of surgical drainage when appropriate, elevation, compresses, and splinting remain important.

Adult↗
PubMed1985

Changing bacteriologic flora of hand infections.

To assess the possibility of a changing bacteriologic flora of hand infections and an alteration in antibiotic susceptibility, a 20-year review of acute hand infections was undertaken. Representative years were completely evaluated during the 20-year span. Over the course of the study Staphylococcus aureus infections decreased from 82% of cultures in 1960 to 34% in 1980. Pure Gram-positive cultures decreased from 85% in 1960 to 50% in 1980. Mixed Gram-positive and Gram-negative infections rose significantly from 8 to 39% over the 20-year study period. Susceptibility of Staphylococcus aureus to penicillin changed from 72% in 1960 to 9% in 1980. Susceptibility of Staphylococcus aureus to the penicillinase-resistant antibiotics and the cephalosporin antibiotics was at 81% and 97%, respectively, in 1980.

Adult↗
PubMed1985

Traumatic hemipelvectomy.

This is a report of a patient who sustained a traumatic avulsion of the hemipelvis and survived this catastrophic challenge. Survival of the patient is dependent on multiple factors of associated injuries, early management, and general health of the patient. Early involvement of the plastic surgical team offers a coordinating influence that can provide the maximum of efficiency for early care and subsequent reconstruction.

Accidents, Traffic↗
PubMed1985

Hand infections in the elderly.

Diagnosis and management of hand infections in the elderly can be challenging. The general principles of rest, elevation, compresses, and drainage when appropriate apply. Antibiotics are important to therapy. Review of data from elderly patients and comparison with a younger population having identical infections show a number of important differences. Temperature, pulse, and white blood cell and differential counts were not elevated significantly enough to be useful. Culture data show fewer pure Staphylococcus aureus infections (20%) and fewer pure gram-positive infections (20%) than the 34% and 56% respectively in a younger population. On the other hand, there were significantly more mixed gram-positive and gram-negative infections (60%). Significantly, the average number of organisms per infection is increased (2.4 vs 1.9 per infection). Antibiotic susceptibility is significantly worse. The cephalosporins and the penicillinase-resistant antibiotics remain good choices.

Adult↗
PubMed1985

Complications in plastic surgical anesthesia.

The possibilities for complications in plastic surgical procedures are widespread. Many of these have been discussed elsewhere in this symposium. An attempt has been made to discuss a few other complications for which immediate action would be necessary by the plastic surgeon in charge. Immediate application of correct principles of diagnosis and treatment can be lifesaving. A thorough understanding of all mechanisms of injury abnormality may not be possible or even required. However, sufficient knowledge should be present to allow prompt diagnosis and initial emergency treatment by the operating surgeon. This knowledge will enable the surgeon to assume his responsibility in the complete care of his patient before, during, and after surgery.

Anesthesia↗
PubMed1985

Regional anesthesia in head and neck surgery.

Regional anesthesia in the head and neck area is a common and effective tool for the plastic surgeon. For short procedures, it offers the advantages of convenience and comfort to the patient. In many procedures, in addition, it offers advantages to the plastic surgeon over general anesthesia. A knowledge of anatomy of the course of the sensory nerves in the head and neck is essential to execute regional anesthesia. Some variability is always present. However, the most important factor in success is practice with a specific technique until it is mastered. No attempt was made in this article to provide an exhaustive reference to all acceptable forms of anesthesia. An attempt was made, however, to indicate one or two successful methods for each type of commonly used block so that when studied and practiced it can be expected to yield consistent results. Some repetition has been unavoidable because the intent has been to provide a relatively self-contained section for each block so that it may be as a reference without having to read the entire article. It is hoped that frequent practice will result in effective local and regional anesthesia in the head and neck area.

Anesthesia, Conduction↗
PubMed1985

Hemostasis in plastic surgical patients.

Every surgeon should be acutely cognizant of the importance of the evaluation and treatment of bleeding abnormalities. Dependence upon a normal platelet and clotting system is a requirement for surgery. Significant emphasis should always be placed on a detailed history and physical examination. Routine laboratory evaluations should be regarded as a screening method and be augmented by suspicion raised during the history and physical examination. The importance of a basic understanding of hemostasis and the correction of abnormalities in hemostasis is essential to the practicing surgeon.

Blood Coagulation↗
PubMed1984

The ability of macrophages from head and neck cancer patients to kill tumor cells. Effect of prostaglandin inhibitors on cytotoxicity.

Monocyte-derived macrophages were isolated from the peripheral blood of 39 patients with either squamous cell carcinomas of the head and neck or basal and/or squamous cell carcinomas of the facial areas. Macrophages from 6 of the 27 patients with squamous cell carcinomas of the head and neck were cytotoxic toward the human tumor cells. When indomethacin, a prostaglandin inhibitor, was added to the noncytotoxic macrophages during the cytotoxicity assay, macrophages from 8 of the 27 patients became cytotoxic for the tumor cells. When 12 patients with basal and/or squamous cell carcinomas of the facial areas were studied, the macrophages from 2 of these patients possessed cytotoxic macrophages. In addition, when indomethacin was added to the noncytotoxic macrophages during the assay, the macrophages from two of these patients became cytotoxic. However, it was also noted that 19 of the 39 patients with either squamous cell carcinomas of the head and neck or basal and/or squamous cell carcinomas of the face possessed macrophages that were noncytotoxic toward the tumor cells in the presence and absence of indomethacin. Macrophage-mediated cytotoxicity was also found to be inhibited by factors present in many cancer patients' plasma. Twelve of the 30 patients with squamous cell carcinomas of the head and neck possessed a plasma inhibitory factor capable of suppressing macrophage-mediated cytotoxicity by more than 50%, whereas no plasma inhibitory factor was found in the patients with basal and/or squamous cell carcinomas of the face. In addition, 29 of the 30 patients studied were incapable of killing the tumor cells in vitro either because they possessed nonresponsive macrophages and/or they possessed a plasma inhibitory factor.

Carcinoma, Squamous Cell↗
PubMed1984

Collagen dynamics of partial small bowel obstruction.

The response of intestinal collagen to obstruction and stress was studied in the rat. Partial small bowel obstructions were created. Preobstruction collagen was measured by injection of tritium labeled proline. New collagen formation after obstruction occurred was followed by injection of carbon-14 labeled proline. At 3 weeks, collagen fractions were identified. Throughout the study, preexisting preobstruction intestinal collagen was metabolically stable with no breakdown or remodeling demonstrable. New collagen formation was rapid and occurred to the largest degree close to the obstruction.

Animals↗
PubMed1983

Comparison of growth-induced resorption and denervation-induced resorption on the release of [3H]tetracycline, 45calcium, and [3H]collagen from whole bones of growing rats.

The major effect of immobilization during growth is a smaller bone mass induced by either an increased bone resorption or a decreased bone formation. Using a method of analyzing radioisotopic loss of [3H]tetracycline and [3H]collagen from bone prelabeled in vivo, we compared the amount of bone resorption due to immobilization with bone resorption induced by growth. One hind limb was denervated in growing male rats, 6 weeks of age, that had been chronically prelabeled with [3H]tetracycline, 45calcium, and [3H]proline. The total radioactivity of the whole femur and tibia/fibula from the denervated limb was compared with that from bones of the control limb at 0, 1, 2, 4, and 8 weeks after denervation. The effect of growth on bone formation was measured by net increases in bone length, volume, and mass of matrix and mineral. Experimental bones had a significantly smaller volume and mass. Bone resorption was much greater during growth modeling than during denervation. The additional bone resorption induced by denervation was a small fraction (one-fourth) of the resorption induced by growth. Denervation during growth resulted in less bone being formed due to a smaller gain in matrix and mineral mass as a result of a reduction in bone formation.

Animals↗
PubMed1982

Localized healing of small intestinal anastomoses.

Small bowel anastomoses were made in a group of adult Sprague-Dawley rats. In another group of animals, interrupted suture of the terminal ileum was performed without transection. The animals were labeled repeatedly by injections of 3H-proline during the second and third week after surgery. Animals were sacrificed at three weeks after anastomosis or suturing. Ten and two mm segments were precisely excised on either side of the anastomoses or suturing. Total collagen and total radioactivity were measured per length of segment. In the small intestine, a similar increase in collagen (four-fold) and its radioactivity (four-fold) occurs only within a centimeter of the anastomotic site, mostly within 0.4 to 0.6 mm. Some of this increase in secondary to the effects of the suture, but most of the increase is due to the anastomosis. The collagen data indicate that the healing of a small intestinal wounds is a local phenomenon.

Animals↗
PubMed1980

Malignant melanoma of the oral cavity.

Primary malignant melanoma of the oral cavity is uncommon. Four cases are presented. The average age is in the sixth decade. Early diagnosis is difficult and prognosis is generally poor. Efforts toward earlier detection and treatment are recommended.

Adult↗
PubMed1979

Malignant melanoma in children.

Six patients with prepubertal malignant melanoma are presented. Three were metastatic. One was congenital in a giant pigmented nevus. A second was found at 6 mo of age to have metastatic lesions. All were treated aggressively and had a favorable outcome. Aggressive treatment, once malignant melanoma is diagnosed, is recommended. Prognosis does not differ markedly from similar lesions in adults.

Adolescent↗
PubMed1979

Effect of nerve graft polarity on nerve regeneration and function.

To evaluate the effect of the polarity of nerve grafts, a 1.0 cm segment of sciatic nerve of 40 adult male Sprague-Dawley rats was excised. In 20 animals the nerve was sutured, maintaining the original polarity. In the order 20 the graft was reversed and sutured into place. Four to 6 months later, the nerves were exposed and directed conduction velocity and amplitude studies were done across the graft. No difference was found between the two groups. Comparison with the control side showed return of 70% to 75% of conduction velocity and amplitude. Nerve graft function was independent of nerve graft polarity.

Animals↗